5DH4

PDE10 complexed with 5-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine

Summary for 5DH4

• Entry DOI: 10.2210/pdb5dh4/pdb
• Related: 5DH5
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q9Y233
• Total number of polymer chains: 2
• Total formula weight: 80330.21

Authors

Yan, Y. (deposition date: 2015-08-29, release date: 2016-01-27)

• Primary citation: Raheem, I.T.,Schreier, J.D.,Fuerst, J.,Gantert, L.,Hostetler, E.D.,Huszar, S.,Joshi, A.,Kandebo, M.,Kim, S.H.,Li, J.,Ma, B.,McGaughey, G.,Sharma, S.,Shipe, W.D.,Uslaner, J.,Vandeveer, G.H.,Yan, Y.,Renger, J.J.,Smith, S.M.,Coleman, P.J.,Cox, C.D.; Discovery of pyrazolopyrimidine phosphodiesterase 10A inhibitors for the treatment of schizophrenia.; Bioorg.Med.Chem.Lett., 26:126-132, 2016; PubMed: 26602277; DOI: 10.1016/j.bmcl.2015.11.013

Experimental method

X-RAY DIFFRACTION (2.2 Å)