3HG3

Human alpha-galactosidase catalytic mechanism 2. Substrate bound

Summary for 3HG3

• Entry DOI: 10.2210/pdb3hg3/pdb
• Related: 1R46 1R47 3HG2 3HG4 3HG5
• Related PRD ID: PRD_900037
• Descriptor: Alpha-galactosidase A, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: glycoprotein, carbohydrate-binding protein, glycosidase, lysosomal enzyme, (beta/alpha)8 barrel, disease mutation, disulfide bond, hydrolase, lysosome
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 97701.24

Authors

Guce, A.I.,Clark, N.E.,Garman, S.C. (deposition date: 2009-05-13, release date: 2009-11-24, Last modification date: 2024-04-03)

• Primary citation: Guce, A.I.,Clark, N.E.,Salgado, E.N.,Ivanen, D.R.,Kulminskaya, A.A.,Brumer, H.,Garman, S.C.; Catalytic mechanism of human alpha-galactosidase.; J.Biol.Chem., 285:3625-3632, 2010; PubMed: 19940122; DOI: 10.1074/jbc.M109.060145

Experimental method

X-RAY DIFFRACTION (1.9 Å)