3HF8

Crystal structure of human tryoptophan hydroxylase type 1 with bound LP-533401 and Fe

Summary for 3HF8

• Entry DOI: 10.2210/pdb3hf8/pdb
• Related: 3HF6 3HFB
• Descriptor: Tryptophan 5-hydroxylase 1, FE (III) ION, 4-{2-amino-6-[(1R)-2,2,2-trifluoro-1-(3'-fluorobiphenyl-4-yl)ethoxy]pyrimidin-4-yl}-L-phenylalanine, ... (4 entities in total)
• Functional Keywords: tryoptophan hydroxylase type 1, iron, metal-binding, monooxygenase, oxidoreductase, phosphoprotein, serotonin biosynthesis
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 33870.24

Authors

Tari, L.W.,Swanson, R.V.,Hunter, M.J. (deposition date: 2009-05-11, release date: 2010-04-21, Last modification date: 2024-02-21)

• Primary citation: Cianchetta, G.,Stouch, T.,Yu, W.,Shi, Z.C.,Tari, L.W.,Swanson, R.V.,Hunter, M.J.,Hoffman, I.D.,Liu, Q.; Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis.; Curr Chem Genomics, 4:19-26, 2010; PubMed: 20556201; DOI: 10.2174/1875397301004010019

Experimental method

X-RAY DIFFRACTION (1.85 Å)