3HF8
Crystal structure of human tryoptophan hydroxylase type 1 with bound LP-533401 and Fe
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tryptophan 5-hydroxylase 1 | polymer | 290 | 33287.9 | 1 | UniProt (P17752) Pfam (PF00351) | Homo sapiens (human) | Tryptophan 5-monooxygenase 1 |
| 2 | B (A) | FE (III) ION | non-polymer | 55.8 | 1 | Chemie (FE) | |||
| 3 | C (A) | 4-{2-amino-6-[(1R)-2,2,2-trifluoro-1-(3'-fluorobiphenyl-4-yl)ethoxy]pyrimidin-4-yl}-L-phenylalanine | non-polymer | 526.5 | 1 | Chemie (ML0) | |||
| 4 | D (A) | water | water | 18.0 | 436 | Chemie (HOH) |
Sequence modifications
A: 104 - 393 (UniProt: P17752)
| PDB | External Database | Details |
|---|---|---|
| Ser 104 | Thr 104 | conflict |
| Arg 179 | Gln 179 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33287.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 582.3 | |
| All* | Total formula weight | 33870.2 |
