6DRX
| Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5HT2B receptor, BRIL chimera, ... | 著者 | McCorvy, J.D, Wacker, D, Wang, S, Agegnehu, B, Liu, J, Lansu, K, Tribo, A.R, Olsen, R.H.J, Che, T, Jin, J, Roth, B.L. | 登録日 | 2018-06-13 | 公開日 | 2018-08-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural determinants of 5-HT2Breceptor activation and biased agonism. Nat. Struct. Mol. Biol., 25, 2018
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6DS0
| Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor | 分子名称: | (1S)-1-[(2-chloro-3,4-dimethoxyphenyl)methyl]-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5HT2B receptor, ... | 著者 | McCorvy, J.D, Wacker, D, Wang, S, Agegnehu, B, Liu, J, Lansu, K, Tribo, A.R, Olsen, R.H.J, Che, T, Jin, J, Roth, B.L. | 登録日 | 2018-06-13 | 公開日 | 2018-08-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.188 Å) | 主引用文献 | Structural determinants of 5-HT2Breceptor activation and biased agonism. Nat. Struct. Mol. Biol., 25, 2018
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4GZN
| Mouse ZFP57 zinc fingers in complex with methylated DNA | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CALCIUM ION, ... | 著者 | Liu, Y, Zhang, X, Cheng, X. | 登録日 | 2012-09-06 | 公開日 | 2012-10-17 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (0.99 Å) | 主引用文献 | An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence. Genes Dev., 26, 2012
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6DA8
| Human CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, Nalpha-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl}-N-[(pyridin-3-yl)methyl]-D-phenylalaninamide, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Sevrioukova, I.F. | 登録日 | 2018-05-01 | 公開日 | 2019-04-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.802 Å) | 主引用文献 | Structure-Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group Stereochemistry, Headgroup Spacing, and Backbone Composition on the Interaction with CYP3A4. Biochemistry, 58, 2019
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6DC5
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6DXE
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4HDA
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4HGA
| Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX | 分子名称: | Death domain-associated protein 6, Histone H3.3, Histone H4, ... | 著者 | Liu, C.P, Xiong, C.Y, Wang, M.Z, Yu, Z.L, Yang, N, Chen, P, Zhang, Z.G, Li, G.H, Xu, R.M. | 登録日 | 2012-10-07 | 公開日 | 2012-11-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.799 Å) | 主引用文献 | Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX. Nat.Struct.Mol.Biol., 19, 2012
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5XGS
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5X3Z
| Solution structure of musashi1 RBD2 in complex with RNA | 分子名称: | RNA (5'-R(*GP*UP*AP*GP*U)-3'), RNA-binding protein Musashi homolog 1 | 著者 | Iwaoka, R, Nagata, T, Tsuda, K, Imai, T, Okano, H, Kobayashi, N, Katahira, M. | 登録日 | 2017-02-09 | 公開日 | 2017-12-13 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Insight into the Recognition of r(UAG) by Musashi-1 RBD2, and Construction of a Model of Musashi-1 RBD1-2 Bound to the Minimum Target RNA Molecules, 22, 2017
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4FML
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5E8O
| The structure of the TEIPP associated altered peptide ligand Trh4-p2ABU in complex with H-2D(b) | 分子名称: | Beta-2-microglobulin, Ceramide synthase 5, H-2 class I histocompatibility antigen, ... | 著者 | Hafstrand, I, Doorduijn, E, Duru, A.D, Buratto, J, Oliveira, C.C, Sandalova, T, van Hall, T, Achour, A. | 登録日 | 2015-10-14 | 公開日 | 2016-02-03 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer. J Immunol., 196, 2016
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2NV7
| Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555 | 分子名称: | 4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME, Estrogen receptor beta, Nuclear receptor coactivator 1 | 著者 | Mewshaw, R.E, Bowen, M.S, Harris, H.A, Xu, Z.B, Manas, E.S, Cohn, S.T, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2006-11-10 | 公開日 | 2007-08-21 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | ERbeta ligands. Part 5: synthesis and structure-activity relationships of a series of 4'-hydroxyphenyl-aryl-carbaldehyde oxime derivatives. Bioorg.Med.Chem.Lett., 17, 2007
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4KMD
| Crystal structure of Sufud60-Gli1p | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, Sufu, ... | 著者 | Zhang, Y, Qi, X, Zhang, Z, Wu, G. | 登録日 | 2013-05-08 | 公開日 | 2013-11-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun, 4, 2013
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4KM9
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4N3Y
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2QCS
| A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state | 分子名称: | ACETATE ION, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Kim, C, Cheng, C.Y, Saldanha, A.S, Taylor, S.S. | 登録日 | 2007-06-19 | 公開日 | 2007-11-06 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell(Cambridge,Mass.), 130, 2007
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4N9J
| Crystal structure of the cryptic polo box domain of human Plk4 | 分子名称: | CHLORIDE ION, SULFATE ION, Serine/threonine-protein kinase PLK4 | 著者 | Ku, B, Kim, J.H, Lee, K.S, Kim, S.J. | 登録日 | 2013-10-21 | 公開日 | 2014-07-02 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis. Nat.Struct.Mol.Biol., 21, 2014
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2P1B
| Crystal structure of human nucleophosmin-core | 分子名称: | Nucleophosmin | 著者 | Lee, H.H, Kim, H.S, Kang, J.Y, Lee, B.I, Ha, J.Y, Yoon, H.J, Lim, S.O, Jung, G, Suh, S.W. | 登録日 | 2007-03-03 | 公開日 | 2007-03-27 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface Proteins, 69, 2007
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4J26
| Estrogen Receptor in complex with proline-flanked LXXLL peptides | 分子名称: | 12-mer Peptide, ESTRADIOL, Estrogen receptor beta | 著者 | Fuchs, S, Nguyen, H.D, Phan, T, Burton, M, Nieto, L, de Vries-van Leeuwen, I, Schmidt, A, Goodarzifard, M, Agten, S, Rose, R, Ottmann, C, Milroy, L.G, Brunsveld, L. | 登録日 | 2013-02-04 | 公開日 | 2013-03-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction J.Am.Chem.Soc., 135, 2013
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4J24
| Estrogen Receptor in complex with proline-flanked LXXLL peptides | 分子名称: | 19-mer peptide, ESTRADIOL, Estrogen receptor beta | 著者 | Fuchs, S, Nguyen, H.D, Phan, T, Burton, M, Nieto, L, de Vries-van Leeuwen, I, Schmidt, A, Goodarzifard, M, Agten, S, Rose, R, Ottmann, C, Milroy, L.G, Brunsveld, L. | 登録日 | 2013-02-04 | 公開日 | 2013-03-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction J.Am.Chem.Soc., 135, 2013
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2OVJ
| The crystal structure of the human Rac GTPase activating protein 1 (RACGAP1) MgcRacGAP. | 分子名称: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, Rac GTPase-activating protein 1 | 著者 | Shrestha, L, Papagrigoriou, E, Soundararajan, M, Elkins, J, Johansson, C, von Delft, F, Pike, A.C.W, Burgess, N, Turnbull, A, Debreczeni, J, Gorrec, F, Umeano, C, Edwards, A, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC) | 登録日 | 2007-02-14 | 公開日 | 2007-02-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | The crystal structure of the human Rac GTPase activating protein 1 (RACGAP1) MgcRacGAP. To be Published
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2OP7
| WW4 | 分子名称: | NEDD4-like E3 ubiquitin-protein ligase WWP1 | 著者 | Qin, H.N, Li, M.F, Pu, H, Sankaran, S, Ahmed, S, Song, J.X. | 登録日 | 2007-01-27 | 公開日 | 2007-12-11 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structure of the forth WW domain of WWP1 To be Published
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4NRA
| Crystal Structure of the bromodomain of human BAZ2B in complex with compound-6 E11322 | 分子名称: | 1,2-ETHANEDIOL, 1-(8-chloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)ethanone, Bromodomain adjacent to zinc finger domain protein 2B | 著者 | Chaikuad, A, Felletar, I, Ferguson, F.M, Filippakopoulos, P, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2013-11-26 | 公開日 | 2013-12-25 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain. J.Med.Chem., 56, 2013
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4NQA
| Crystal structure of liganded hRXR-alpha/hLXR-beta heterodimer on DNA | 分子名称: | (9cis)-retinoic acid, 5'-D(*TP*AP*AP*GP*GP*TP*CP*AP*CP*TP*TP*CP*AP*GP*GP*TP*CP*A)-3', 5'-D(*TP*AP*TP*GP*AP*CP*CP*TP*GP*AP*AP*GP*TP*GP*AP*CP*CP*T)-3', ... | 著者 | Lou, X.H, Toresson, G, Benod, C, Suh, J.H, Phillips, K.J, Webb, P, Gustafsson, J.A. | 登録日 | 2013-11-24 | 公開日 | 2014-02-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.102 Å) | 主引用文献 | Structure of the retinoid X receptor alpha-liver X receptor beta (RXR alpha-LXR beta ) heterodimer on DNA. Nat.Struct.Mol.Biol., 21, 2014
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