4HDA

Crystal structure of human Sirt5 in complex with Fluor-de-Lys peptide and resveratrol

Summary for 4HDA

• Entry DOI: 10.2210/pdb4hda/pdb
• Related: 4HD8
• Descriptor: NAD-dependent protein deacylase sirtuin-5, mitochondrial, Fluor-de-Lys peptide, ZINC ION, ... (5 entities in total)
• Functional Keywords: nad-dependent deacetylase, sirtuin, mitochondrial, activator complex, resveratrol, hydrolase-hydrolase activator complex, hydrolase/hydrolase activator
• Biological source: Homo sapiens (human); More
• Cellular location: Mitochondrion matrix. Isoform 1: Cytoplasm. Isoform 2: Mitochondrion: Q9NXA8
• Total number of polymer chains: 3
• Total formula weight: 60955.13

Authors

Gertz, M.,Steegborn, C. (deposition date: 2012-10-02, release date: 2012-12-05, Last modification date: 2024-02-28)

• Primary citation: Gertz, M.,Nguyen, G.T.,Fischer, F.,Suenkel, B.,Schlicker, C.,Franzel, B.,Tomaschewski, J.,Aladini, F.,Becker, C.,Wolters, D.,Steegborn, C.; A molecular mechanism for direct sirtuin activation by resveratrol.; Plos One, 7:e49761-e49761, 2012; PubMed: 23185430; DOI: 10.1371/journal.pone.0049761

Experimental method

X-RAY DIFFRACTION (2.601 Å)