4HDA
Crystal structure of human Sirt5 in complex with Fluor-de-Lys peptide and resveratrol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| A | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| B | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 401 |
| Chain | Residue |
| A | CYS166 |
| A | CYS169 |
| A | CYS207 |
| A | CYS212 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 401 |
| Chain | Residue |
| B | CYS166 |
| B | CYS169 |
| B | CYS207 |
| B | CYS212 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE STL B 402 |
| Chain | Residue |
| B | GLY72 |
| B | THR279 |
| F | FDL4 |
| B | LYS51 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:29180469 |
| Chain | Residue | Details |
| A | HIS158 | |
| B | HIS158 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:22767592, ECO:0000269|Ref.19 |
| Chain | Residue | Details |
| A | GLY58 | |
| B | CYS293 | |
| A | GLN140 | |
| A | GLY249 | |
| A | ASN275 | |
| A | CYS293 | |
| B | GLY58 | |
| B | GLN140 | |
| B | GLY249 | |
| B | ASN275 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03160 |
| Chain | Residue | Details |
| A | TYR102 | |
| B | CYS169 | |
| B | CYS207 | |
| B | CYS212 | |
| A | ARG105 | |
| A | CYS166 | |
| A | CYS169 | |
| A | CYS207 | |
| A | CYS212 | |
| B | TYR102 | |
| B | ARG105 | |
| B | CYS166 |
