4HDA
Crystal structure of human Sirt5 in complex with Fluor-de-Lys peptide and resveratrol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | polymer | 275 | 29913.1 | 2 | UniProt (Q9NXA8) Pfam (PF02146) | Homo sapiens (human) | Regulatory protein SIR2 homolog 5, SIR2-like protein 5 |
| 2 | C (F) | Fluor-de-Lys peptide | polymer | 4 | 769.9 | 1 | |||
| 3 | D, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F (B) | RESVERATROL | non-polymer | 228.2 | 1 | Chemie (STL) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 15 | Chemie (HOH) |
Sequence modifications
A, B: 34 - 302 (UniProt: Q9NXA8)
| PDB | External Database | Details |
|---|---|---|
| Gly 28 | - | expression tag |
| Ile 29 | - | expression tag |
| Asp 30 | - | expression tag |
| Pro 31 | - | expression tag |
| Phe 32 | - | expression tag |
| Thr 33 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 60596.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 359.1 | |
| All* | Total formula weight | 60955.1 |
