4HD8

Crystal structure of human Sirt3 in complex with Fluor-de-Lys peptide and piceatannol

Summary for 4HD8

• Entry DOI: 10.2210/pdb4hd8/pdb
• Related: 4HDA
• Descriptor: NAD-dependent protein deacetylase sirtuin-3, mitochondrial, Fluor-de-Lys peptide, ZINC ION, ... (6 entities in total)
• Functional Keywords: nad-dependent deacetylase, sirtuin, mitochondrial, inhibitor complex, piceatannol, resveratrol-like compound, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Mitochondrion matrix: Q9NTG7
• Total number of polymer chains: 2
• Total formula weight: 32623.88

Authors

Nguyen, G.T.T.,Gertz, M.,Steegborn, C. (deposition date: 2012-10-02, release date: 2012-12-05, Last modification date: 2024-02-28)

• Primary citation: Gertz, M.,Nguyen, G.T.,Fischer, F.,Suenkel, B.,Schlicker, C.,Franzel, B.,Tomaschewski, J.,Aladini, F.,Becker, C.,Wolters, D.,Steegborn, C.; A molecular mechanism for direct sirtuin activation by resveratrol.; Plos One, 7:e49761-e49761, 2012; PubMed: 23185430; DOI: 10.1371/journal.pone.0049761

Experimental method

X-RAY DIFFRACTION (2.3 Å)