4HD8
Crystal structure of human Sirt3 in complex with Fluor-de-Lys peptide and piceatannol
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 401 |
| Chain | Residue |
| A | CYS256 |
| A | CYS259 |
| A | CYS280 |
| A | CYS283 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PIT A 402 |
| Chain | Residue |
| A | GLY295 |
| A | HOH596 |
| A | HOH600 |
| A | HOH600 |
| F | LYS3 |
| F | LYS3 |
| F | FDL4 |
| F | FDL4 |
| A | GLU181 |
| A | GLU181 |
| A | PHE294 |
| A | PHE294 |
| A | GLY295 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IPA A 403 |
| Chain | Residue |
| A | GLN300 |
| A | LEU304 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR CHAIN F OF FLUOR-DE-LYS PEPTIDE |
| Chain | Residue |
| A | TYR175 |
| A | GLU177 |
| A | PHE180 |
| A | GLU181 |
| A | HIS248 |
| A | ILE291 |
| A | VAL292 |
| A | PHE293 |
| A | PHE294 |
| A | GLY295 |
| A | GLU296 |
| A | PRO297 |
| A | LEU298 |
| A | GLU325 |
| A | PRO326 |
| A | PIT402 |
| A | PIT402 |
| A | HOH564 |
| F | HOH101 |
| F | HOH102 |
| F | HOH103 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12186850","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16788062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18794531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19535340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37720100","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19535340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8R104","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
