PDB: 5470 件ウェブページステータス検索Chemie searchBIRD

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6YOV	OCT4-SOX2-bound nucleosome - SHL+6 分子名称: DNA (142-MER), Green fluorescent protein,POU domain, class 5, ... 著者 Michael, A.K, Kempf, G, Cavadini, S, Bunker, R.D, Thoma, N.H. 登録日 2020-04-15 公開日 2020-05-06 最終更新日 2020-07-08 実験手法 ELECTRON MICROSCOPY (3.42 Å) 主引用文献 Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science, 368, 2020
3K5U	Identification, SAR Studies and X-ray Cocrystal Analysis of a Novel Furano-pyrimidine Aurora Kinase A Inhibitor 分子名称: 2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL, Serine/threonine-protein kinase 6 著者 Wu, J.S, Leou, J.S, Coumar, M.S, Hsieh, H.P, Wu, S.Y. 登録日 2009-10-08 公開日 2010-10-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Identification, SAR studies, and X-ray co-crystallographic analysis of a novel furanopyrimidine aurora kinase A inhibitor Chemmedchem, 5, 2010
4V98	The 8S snRNP Assembly Intermediate 分子名称: CG10419, Icln, LD23602p, ... 著者 Grimm, C, Pelz, J.P, Schindelin, H, Diederichs, K, Kuper, J, Kisker, C. 登録日 2012-05-15 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural Basis of Assembly Chaperone- Mediated snRNP Formation. Mol.Cell, 49, 2013
4USG	Crystal structure of PC4 W89Y mutant complex with DNA 分子名称: 5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP *TP*TP*TP*TP*TP*G)-3', ACTIVATED RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR P15 著者 Zhao, Y, Liu, J. 登録日 2014-07-08 公開日 2015-03-18 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.973 Å) 主引用文献 Substitution of Tryptophan 89 with Tyrosine Switches the DNA Binding Mode of Pc4. Sci.Rep., 5, 2015
3X1S	Crystal structure of the nucleosome core particle 分子名称: CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... 著者 Sivaraman, P, Kumarevel, T.S. 登録日 2014-11-27 公開日 2015-09-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.805 Å) 主引用文献 Structural and functional analyses of nucleosome complexes with mouse histone variants TH2a and TH2b, involved in reprogramming Biochem.Biophys.Res.Commun., 464, 2015
6YAN	Mammalian 48S late-stage translation initiation complex with histone 4 mRNA 分子名称: 18S ribosomal RNA, 40S ribosomal protein S12, 40S ribosomal protein S21, ... 著者 Bochler, A, Simonetti, A, Guca, E, Hashem, Y. 登録日 2020-03-12 公開日 2020-04-08 最終更新日 2020-04-22 実験手法 ELECTRON MICROSCOPY (3.48 Å) 主引用文献 Structural Insights into the Mammalian Late-Stage Initiation Complexes. Cell Rep, 31, 2020
3JPX	EED: A Novel Histone Trimethyllysine Binder Within The EED-EZH2 Polycomb Complex 分子名称: HISTONE PEPTIDE, Polycomb protein EED 著者 Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) 登録日 2009-09-04 公開日 2009-10-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
3JT0	Crystal Structure of the C-terminal fragment (426-558) Lamin-B1 from Homo sapiens, Northeast Structural Genomics Consortium Target HR5546A 分子名称: Lamin-B1 著者 Kuzin, A, Abashidze, M, Seetharaman, J, Sahdev, S, Xiao, R, Ciccosanti, C, Belote, R.L, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) 登録日 2009-09-11 公開日 2009-09-22 最終更新日 2019-07-24 実験手法 X-RAY DIFFRACTION (2.392 Å) 主引用文献 Northeast Structural Genomics Consortium Target HR5546A To be Published
4UV9	LSD1(KDM1A)-CoREST in complex with 1-Ethyl-Tranylcypromine 分子名称: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS,10aS)-4a-[(1S,3E)-3-imino-1-phenylpentyl]-7,8-dimethyl-2,4-dioxo-1,3,4,4a,5,10a-hexahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate 著者 Vianello, P, Botrugno, O, Cappa, A, Ciossani, G, Dessanti, P, Mai, A, Mattevi, A, Meroni, G, Minucci, S, Thaler, F, Tortorici, M, Trifiro, P, Valente, S, Villa, M, Varasi, M, Mercurio, C. 登録日 2014-08-05 公開日 2014-09-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A. Eur.J.Med.Chem., 86C, 2014
7BU5	Crystal Structure of Human SLX4 and MUS81 分子名称: GLYCINE, MUS81 endonuclease homolog (Yeast), isoform CRA_b, ... 著者 Wan, B, Wu, J, Lei, M. 登録日 2020-04-04 公開日 2021-04-07 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 SLX4 control MUS81 endonuclease function in telomere through an intermolecular SAP domain To be published
6FML	CryoEM Structure INO80core Nucleosome complex 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin related protein 5, ... 著者 Eustermann, S, Schall, K, Kostrewa, D, Strauss, M, Hopfner, K. 登録日 2018-01-31 公開日 2018-04-25 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.34 Å) 主引用文献 Structural basis for ATP-dependent chromatin remodelling by the INO80 complex. Nature, 556, 2018
4UVB	LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1S,2R) 分子名称: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,7aS)-1-amino-1,10,11-trimethyl-4,6-dioxo-3-phenyl-2,3,5,6,7,7a-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate 著者 Vianello, P, Botrugno, O, Cappa, A, Ciossani, G, Dessanti, P, Mai, A, Mattevi, A, Meroni, G, Minucci, S, Thaler, F, Tortorici, M, Trifiro, P, Valente, S, Villa, M, Varasi, M, Mercurio, C. 登録日 2014-08-05 公開日 2014-09-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A. Eur.J.Med.Chem., 86C, 2014
4UXN	LSD1(KDM1A)-CoREST in complex with Z-Pro derivative of MC2580 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, ... 著者 Rodriguez, V, Valente, S, Stazi, G, Lucidi, A, Mercurio, C, Vianello, P, Ciossani, G, Mattevi, A, Botrugno, O.A, Dessanti, P, Minucci, S, Varasi, M, Mai, A. 登録日 2014-08-27 公開日 2015-02-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Pyrrole- and Indole-Containing Tranylcypromine Derivatives as Novel Lysine-Specific Demethylase 1 Inhibitors Active on Cancer Cells Chemmedchem, 6, 2015
3K6G	Crystal structure of Rap1 and TRF2 complex 分子名称: Telomeric repeat-binding factor 2, Telomeric repeat-binding factor 2-interacting protein 1 著者 Chen, Y, Rai, R, Yang, Y.T, Zheng, H, Chang, S, Lei, M. 登録日 2009-10-08 公開日 2010-10-13 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat.Struct.Mol.Biol., 18, 2011
7B9X	NMR2 structure of TRIM24-BD in complex with a precursor of IACS-9571 分子名称: N-{6-[3-(4-Aminobutoxy)-5-propoxyphenoxy]-1,3-dimethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl}-3,4-dimethoxybenzene-1-sulfonamide, Transcription intermediary factor 1-alpha 著者 Orts, J, Torres, F, Milbradt, A.G, Walser, R. 登録日 2020-12-14 公開日 2022-01-12 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24. J.Med.Chem., 65, 2022
4UYD	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 1,3-dimethyl-2-oxo-2,3- dihydro-1H-1,3-benzodiazole-5-carboxamide 分子名称: 1,2-ETHANEDIOL, 1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazole-5-carboxamide, BROMODOMAIN-CONTAINING PROTEIN 4, ... 著者 Chung, C, Bamborough, P, Demont, E. 登録日 2014-08-30 公開日 2014-09-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 1,3-Dimethyl Benzimidazolones are Potent, Selective Inhibitors of the Brpf1 Bromodomain. Acs Med.Chem.Lett., 5, 2014
6G16	Structure of the human RBBP4:MTA1(464-546) complex showing loop exchange 分子名称: Histone-binding protein RBBP4, Metastasis-associated protein MTA1 著者 Millard, C.J, Varma, N, Fairall, L, Schwabe, J.W.R. 登録日 2018-03-20 公開日 2018-06-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The structure of the core NuRD repression complex provides insights into its interaction with chromatin. Elife, 5, 2016
7BV9	The NMR structure of the BEN domain from human NAC1 分子名称: Nucleus accumbens-associated protein 1 著者 Nagata, T, Kobayashi, N, Nakayama, N, Obayashi, E, Urano, T. 登録日 2020-04-09 公開日 2021-02-17 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Nucleus Accumbens-Associated Protein 1 Binds DNA Directly through the BEN Domain in a Sequence-Specific Manner. Biomedicines, 8, 2020
6YJD	Lamin A coil2 dimer stabilized by N-terminal capping 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Capsid assembly scaffolding protein,Prelamin-A/C, ... 著者 Lilina, A.V, Stalmans, G, Strelkov, S.V. 登録日 2020-04-03 公開日 2021-02-24 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Addressing the Molecular Mechanism of Longitudinal Lamin Assembly Using Chimeric Fusions. Cells, 9, 2020
6GG5	Crystal structure of M2 PYK in complex with Tryptophan. 分子名称: PHOSPHATE ION, POTASSIUM ION, Pyruvate kinase PKM, ... 著者 McNae, I.W, Yuan, M, Walkinshaw, M.D. 登録日 2018-05-02 公開日 2018-05-23 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor. Biochem. J., 475, 2018
6GHD	Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases 分子名称: 1,2-ETHANEDIOL, Barrier-to-autointegration factor, Emerin, ... 著者 Samson, C, Petitalot, A, Celli, F, Herrada, I, Ropars, V, Ledu, M.H, Nhiri, N, Arteni, A.A, Buendia, B, ZinnJustin, S. 登録日 2018-05-07 公開日 2018-08-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases. Nucleic Acids Res., 46, 2018
6GU6	CDK1/Cks2 in complex with Dinaciclib 分子名称: 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2 著者 Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P. 登録日 2018-06-19 公開日 2018-12-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. Cell Chem Biol, 26, 2019
6GG6	Crystal structure of M2 PYK in complex with Serine. 分子名称: MAGNESIUM ION, PHOSPHATE ION, POTASSIUM ION, ... 著者 McNae, I.W, Yuan, M, Walkinshaw, M.D. 登録日 2018-05-02 公開日 2018-05-23 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.96 Å) 主引用文献 An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor. Biochem. J., 475, 2018
6GG3	Crystal structure of M2 PYK in complex with Alanine. 分子名称: ALANINE, PHOSPHATE ION, Pyruvate kinase PKM 著者 McNae, I.W, Yuan, M, Walkinshaw, M.D. 登録日 2018-05-02 公開日 2019-09-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.72 Å) 主引用文献 An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor. Biochem.J., 475, 2018
6GU4	CDK1/CyclinB/Cks2 in complex with CGP74514A 分子名称: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ... 著者 Wood, D.J, Korolchuk, S, Tatum, N.J, Wang, L.Z, Endicott, J.A, Noble, M.E.M, Martin, M.P. 登録日 2018-06-19 公開日 2018-12-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.73 Å) 主引用文献 Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition. Cell Chem Biol, 26, 2019

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