4UVB
LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1S,2R)
Summary for 4UVB
Entry DOI | 10.2210/pdb4uvb/pdb |
Related | 4UV8 4UV9 4UVA 4UVC |
Descriptor | LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-5-[(1R,3S,3aS,7aS)-1-amino-1,10,11-trimethyl-4,6-dioxo-3-phenyl-2,3,5,6,7,7a-hexahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]-2,3,4-trihydroxypentyl dihydrogen diphosphate (3 entities in total) |
Functional Keywords | transcription, covalent inhibitor |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus: O60341 Q9UKL0 |
Total number of polymer chains | 2 |
Total formula weight | 148882.98 |
Authors | Vianello, P.,Botrugno, O.,Cappa, A.,Ciossani, G.,Dessanti, P.,Mai, A.,Mattevi, A.,Meroni, G.,Minucci, S.,Thaler, F.,Tortorici, M.,Trifiro, P.,Valente, S.,Villa, M.,Varasi, M.,Mercurio, C. (deposition date: 2014-08-05, release date: 2014-09-10, Last modification date: 2024-01-10) |
Primary citation | Vianello, P.,Botrugno, O.A.,Cappa, A.,Ciossani, G.,Dessanti, P.,Mai, A.,Mattevi, A.,Meroni, G.,Minucci, S.,Thaler, F.,Tortorici, M.,Trifiro, P.,Valente, S.,Villa, M.,Varasi, M.,Mercurio, C. Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A. Eur.J.Med.Chem., 86C:352-, 2014 Cited by PubMed: 25173853DOI: 10.1016/J.EJMECH.2014.08.068 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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