7B9X
NMR2 structure of TRIM24-BD in complex with a precursor of IACS-9571
Summary for 7B9X
| Entry DOI | 10.2210/pdb7b9x/pdb |
| NMR Information | BMRB: 34583 |
| Descriptor | Transcription intermediary factor 1-alpha, N-{6-[3-(4-Aminobutoxy)-5-propoxyphenoxy]-1,3-dimethyl-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl}-3,4-dimethoxybenzene-1-sulfonamide (2 entities in total) |
| Functional Keywords | trim24, bromodomain, iacs-9571, nmr2, oncoprotein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 13194.15 |
| Authors | Orts, J.,Torres, F.,Milbradt, A.G.,Walser, R. (deposition date: 2020-12-14, release date: 2022-01-12, Last modification date: 2022-04-27) |
| Primary citation | Torres, F.,Walser, R.,Kaderli, J.,Rossi, E.,Bobby, R.,Packer, M.J.,Sarda, S.,Walker, G.,Hitchin, J.R.,Milbradt, A.G.,Orts, J. NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24. J.Med.Chem., 65:5565-5574, 2022 Cited by PubMed: 35357834DOI: 10.1021/acs.jmedchem.1c01703 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
Download full validation report
