5JMN
| Fusidic acid bound AcrB | 分子名称: | 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 3,6,9,12,15-PENTAOXAHEPTADECANE, DARPin, ... | 著者 | Oswald, C, Tam, H.K, Pos, K.M. | 登録日 | 2016-04-29 | 公開日 | 2016-12-21 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB. Nat Commun, 7, 2016
|
|
5LQ3
| |
5NC5
| |
5NG5
| multi-drug efflux; membrane transport; RND superfamily; Drug resistance | 分子名称: | 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, ... | 著者 | Wang, Z, Fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D. | 登録日 | 2017-03-16 | 公開日 | 2017-04-19 | 最終更新日 | 2017-08-02 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump. Elife, 6, 2017
|
|
5O66
| Asymmetric AcrABZ-TolC | 分子名称: | Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, Multidrug efflux pump subunit AcrB, ... | 著者 | Du, D, Luisi, B.F. | 登録日 | 2017-06-05 | 公開日 | 2017-06-14 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump. Elife, 6, 2017
|
|
5T0O
| |
5V5S
| multi-drug efflux; membrane transport; RND superfamily; Drug resistance | 分子名称: | Multidrug efflux pump subunit AcrA, Multidrug efflux pump subunit AcrB, Outer membrane protein TolC | 著者 | wang, Z, fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D. | 登録日 | 2017-03-15 | 公開日 | 2017-04-19 | 最終更新日 | 2019-10-23 | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | 主引用文献 | An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump. Elife, 6, 2017
|
|
5YIL
| Hoisting-loop in bacterial multidrug exporter AcrB is a highly flexible hinge that enables the large motion of the subdomains | 分子名称: | Multidrug efflux pump subunit AcrB | 著者 | Zwama, M, Sakurai, K, Hayashi, K, Nakashima, R, Kitagawa, K, Nishino, K, Yamaguchi, A. | 登録日 | 2017-10-05 | 公開日 | 2017-11-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Hoisting-Loop in Bacterial Multidrug Exporter AcrB Is a Highly Flexible Hinge That Enables the Large Motion of the Subdomains. Front Microbiol, 8, 2017
|
|
6BAJ
| |
6CSX
| |
6IIA
| MexB in complex with LMNG | 分子名称: | Lauryl Maltose Neopentyl Glycol, Multidrug resistance protein MexB | 著者 | Nakashima, R, Sakurai, K, Nakao, K. | 登録日 | 2018-10-04 | 公開日 | 2019-03-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Crystal structures of multidrug efflux pump MexB bound with high-molecular-mass compounds. Sci Rep, 9, 2019
|
|
6IOK
| Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state) | 分子名称: | Multidrug resistance protein MexA, Multidrug resistance protein MexB, Outer membrane protein OprM | 著者 | Tsutsumi, K, Yonehara, R, Nakagawa, A, Yamashita, E. | 登録日 | 2018-10-30 | 公開日 | 2019-04-03 | 最終更新日 | 2019-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism. Nat Commun, 10, 2019
|
|
6IOL
| Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state) | 分子名称: | Multidrug resistance protein MexA, Multidrug resistance protein MexB, Outer membrane protein OprM | 著者 | Tsutsumi, K, Yonehara, R, Nakagawa, A, Yamashita, E. | 登録日 | 2018-10-30 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | 主引用文献 | Structures of the wild-type MexAB-OprM tripartite pump reveal its complex formation and drug efflux mechanism. Nat Commun, 10, 2019
|
|
6NZI
| |
6OWS
| |
6Q4N
| Fusidic acid bound AcrB_V340A | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, DARPin, DECANE, ... | 著者 | Tam, H.K, Pos, K.M. | 登録日 | 2018-12-06 | 公開日 | 2019-11-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB. J.Mol.Biol., 432, 2020
|
|
6Q4O
| Fusidic acid bound AcrB_I27A | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, DARPIN, DECANE, ... | 著者 | Tam, H.K, Pos, K.M. | 登録日 | 2018-12-06 | 公開日 | 2019-11-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB. J.Mol.Biol., 432, 2020
|
|
6Q4P
| Fusidic acid bound AcrB_N298A | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, CHLORIDE ION, ... | 著者 | Tam, H.K, Pos, K.M. | 登録日 | 2018-12-06 | 公開日 | 2019-11-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB. J.Mol.Biol., 432, 2020
|
|
6SGR
| Cryo-EM structure of Escherichia coli AcrBZ and DARPin in Saposin A-nanodisc with cardiolipin | 分子名称: | DARPin, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrB | 著者 | Szewczak-Harris, A, Du, D, Newman, C, Neuberger, A, Luisi, B.F. | 登録日 | 2019-08-05 | 公開日 | 2020-05-13 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment. Structure, 28, 2020
|
|
6SGS
| Cryo-EM structure of Escherichia coli AcrBZ and DARPin in Saposin A-nanodisc | 分子名称: | DARPin, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrB | 著者 | Szewczak-Harris, A, Du, D, Newman, C, Neuberger, A, Luisi, B.F. | 登録日 | 2019-08-05 | 公開日 | 2020-05-13 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment. Structure, 28, 2020
|
|
6SGT
| Cryo-EM structure of Escherichia coli AcrB and DARPin in Saposin A-nanodisc with cardiolipin | 分子名称: | DARPin, Multidrug efflux pump subunit AcrB | 著者 | Szewczak-Harris, A, Du, D, Newman, C, Neuberger, A, Luisi, B.F. | 登録日 | 2019-08-05 | 公開日 | 2020-05-13 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment. Structure, 28, 2020
|
|
6SGU
| Cryo-EM structure of Escherichia coli AcrB and DARPin in Saposin A-nanodisc | 分子名称: | DARPin, Multidrug efflux pump subunit AcrB | 著者 | Szewczak-Harris, A, Du, D, Newman, C, Neuberger, A, Luisi, B.F. | 登録日 | 2019-08-05 | 公開日 | 2020-05-13 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment. Structure, 28, 2020
|
|
6T7S
| MexB structure solved by cryo-EM in nanodisc in absence of its protein partners | 分子名称: | Efflux pump membrane transporter | 著者 | Glavier, M, Schoehn, G, Taveau, J.C, Phan, G, Daury, L, Lambert, O, Broutin, I. | 登録日 | 2019-10-23 | 公開日 | 2020-09-16 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex. Nat Commun, 11, 2020
|
|
6TA5
| OprM-MexA complex from the MexAB-OprM Pseudomonas aeruginosa whole assembly reconstituted in nanodiscs | 分子名称: | Efflux pump membrane transporter, MexA family multidrug efflux RND transporter periplasmic adaptor subunit, Outer membrane protein OprM | 著者 | Glavier, M, Schoehn, G, Taveau, J.C, Phan, G, Daury, L, Lambert, O, Broutin, I. | 登録日 | 2019-10-29 | 公開日 | 2020-09-16 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex. Nat Commun, 11, 2020
|
|
6TA6
| MexAB assembly of the Pseudomonas MexAB-OprM efflux pump reconstituted in nanodiscs | 分子名称: | Efflux pump membrane transporter, MexA family multidrug efflux RND transporter periplasmic adaptor subunit, Outer membrane protein OprM | 著者 | Glavier, M, Schoehn, G, Taveau, J.C, Phan, G, Daury, L, Lambert, O, Broutin, I. | 登録日 | 2019-10-29 | 公開日 | 2020-09-16 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex. Nat Commun, 11, 2020
|
|