7Q5B
 
 | | Cryo-EM structure of Ty3 retrotransposon targeting a TFIIIB-bound tRNA gene | | 分子名称: | DNA (19-MER), DNA (31-MER), DNA (34-MER), ... | | 著者 | Abascal-Palacios, G, Jochem, L, Pla-Prats, C, Beuron, F, Vannini, A. | | 登録日 | 2021-11-03 | | 公開日 | 2022-01-26 | | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | | 主引用文献 | Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes.
Nat Commun, 12, 2021
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6MEC
 | | Structure of a group II intron retroelement after DNA integration | | 分子名称: | MAGNESIUM ION, Maturase reverse transcriptase, SODIUM ION, ... | | 著者 | Haack, D, Yan, X, Zhang, C, Hingey, J, Lyumkis, D, Baker, T.S, Toor, N. | | 登録日 | 2018-09-06 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA.
Cell, 178, 2019
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7QXS
 | | Cryo-EM structure of human telomerase-DNA-TPP1-POT1 complex (with POT1 side chains) | | 分子名称: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | | 著者 | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | | 登録日 | 2022-01-27 | | 公開日 | 2022-03-02 | | 最終更新日 | 2022-03-23 | | 実験手法 | ELECTRON MICROSCOPY (3.91 Å) | | 主引用文献 | Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
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7QXA
 | | Cryo-EM map of human telomerase-DNA-TPP1 complex (sharpened) | | 分子名称: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | | 著者 | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | | 登録日 | 2022-01-26 | | 公開日 | 2022-03-02 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
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7QXB
 | | Cryo-EM map of human telomerase-DNA-TPP1-POT1 complex (sharpened map) | | 分子名称: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | | 著者 | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | | 登録日 | 2022-01-26 | | 公開日 | 2022-03-02 | | 最終更新日 | 2022-03-23 | | 実験手法 | ELECTRON MICROSCOPY (3.91 Å) | | 主引用文献 | Structural basis of human telomerase recruitment by TPP1-POT1.
Science, 375, 2022
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5G2X
 | | Structure a of Group II Intron Complexed with its Reverse Transcriptase | | 分子名称: | 5'-R(*CP*AP*CP*AP*UP*CP*CP*AP*UP*AP*AP*CP)-3', GROUP II INTRON, GROUP II INTRON-ENCODED PROTEIN LTRA | | 著者 | Qu, G, Kaushal, P.S, Wang, J, Shigematsu, H, Piazza, C.L, Agrawal, R.K, Belfort, M, Wang, H.W. | | 登録日 | 2016-04-16 | | 公開日 | 2016-05-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure of a Group II Intron in Complex with its Reverse Transcriptase.
Nat.Struct.Mol.Biol., 23, 2016
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5CQG
 | | Structure of Tribolium telomerase in complex with the highly specific inhibitor BIBR1532 | | 分子名称: | 2-{[(2E)-3-(naphthalen-2-yl)but-2-enoyl]amino}benzoic acid, Telomerase reverse transcriptase | | 著者 | Bryan, C, Rice, C, Hoffman, H, Harkisheimer, M, Sweeney, M, Skordalakes, E. | | 登録日 | 2015-07-21 | | 公開日 | 2015-09-09 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532.
Structure, 23, 2015
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7BG9
 | | The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate | | 分子名称: | DNA (5'-D(P*TP*TP*AP*GP*GP*G)-3'), Histone H2A, Histone H2B, ... | | 著者 | Nguyen, T.H.D, Ghanim, G.E, Fountain, A.J, van Roon, A.M.M, Rangan, R, Das, R, Collins, K. | | 登録日 | 2021-01-06 | | 公開日 | 2021-04-28 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure of human telomerase holoenzyme with bound telomeric DNA.
Nature, 593, 2021
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7D0F
 | | cryo-EM structure of a pre-catalytic group II intron RNP | | 分子名称: | Group II intron-encoded protein LtrA, RNA (738-MER) | | 著者 | Liu, N, Dong, X.L, Hu, C.X, Zeng, J.W, Wang, J.W, Wang, J, Wang, H.W, Belfort, M. | | 登録日 | 2020-09-10 | | 公開日 | 2020-09-30 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (5 Å) | | 主引用文献 | Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing.
Nucleic Acids Res., 48, 2020
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7D0G
 | | Cryo-EM structure of a pre-catalytic group II intron | | 分子名称: | Group II intron-encoded protein LtrA, RNA (714-MER) | | 著者 | Liu, N, Dong, X.L, Hu, C.X, Zeng, J.W, Wang, J.W, Wang, J, Wang, H.W, Belfort, M. | | 登録日 | 2020-09-10 | | 公開日 | 2020-09-30 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (5 Å) | | 主引用文献 | Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing.
Nucleic Acids Res., 48, 2020
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4OL8
 | | Ty3 reverse transcriptase bound to DNA/RNA | | 分子名称: | 5'-D(*CP*AP*TP*CP*TP*TP*CP*CP*TP*CP*TP*CP*TP*CP*TP*C)-3', 5'-R(*CP*UP*GP*AP*GP*AP*GP*AP*GP*AP*GP*GP*AP*AP*GP*AP*UP*G)-3', Reverse transcriptase/ribonuclease H, ... | | 著者 | Nowak, E, Miller, J.T, Bona, M.K, Studnicka, J, Szczepanowski, R.H, Jurkowski, J, Le Grice, S.F.J, Nowotny, M. | | 登録日 | 2014-01-23 | | 公開日 | 2014-03-05 | | 最終更新日 | 2014-04-16 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry.
Nat.Struct.Mol.Biol., 21, 2014
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7V99
 | | catalytic core of human telomerase holoenzyme | | 分子名称: | Histone H2A type 1-B/E, Histone H2B type 1-K, Primer DNA, ... | | 著者 | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2021-08-24 | | 公開日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Zipper head mechanism of telomere synthesis by human telomerase.
Cell Res., 31, 2021
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7O0H
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4KSE
 | | Crystal structure of a HIV p51 (219-230) deletion mutant | | 分子名称: | 1,2-ETHANEDIOL, HIV p51 subunit | | 著者 | Zheng, X, Mueller, G.A, Derose, E.F, Pedersen, L.C, Gabel, S.A, Cuneo, M.J, Krahn, J.M, London, R.E. | | 登録日 | 2013-05-17 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.677 Å) | | 主引用文献 | Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation.
Nucleic Acids Res., 42, 2014
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3DU6
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3DU5
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6USO
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6USP
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6USQ
 | | Telomerase Reverse Transcriptase binary complex with Y256A mutation, TERT:DNA | | 分子名称: | DNA (5'-D(*GP*GP*TP*CP*AP*GP*GP*TP*CP*AP*GP*GP*TP*CP*A)-3'), DNA/RNA (5'-R(*CP*UP*GP*AP*CP*CP*UP*GP*AP*C)-D(P*CP*T)-R(P*GP*AP*C)-D(P*C)-3'), MAGNESIUM ION, ... | | 著者 | Schaich, M.A, Freudenthal, B.D, Khoang, T.H. | | 登録日 | 2019-10-28 | | 公開日 | 2020-06-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.62 Å) | | 主引用文献 | Mechanisms of nucleotide selection by telomerase.
Elife, 9, 2020
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6USR
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7TRD
 | | Human telomerase catalytic core structure at 3.3 Angstrom | | 分子名称: | Telomerase RNA, partial sequence, Telomerase reverse transcriptase, ... | | 著者 | Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. | | 登録日 | 2022-01-28 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of active human telomerase with telomere shelterin protein TPP1.
Nature, 604, 2022
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7TRF
 | | Human telomerase catalytic core RNP with H2A/H2B | | 分子名称: | Histone H2A, Histone H2B type 1-C/E/F/G/I, Telomerase RNA, ... | | 著者 | Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. | | 登録日 | 2022-01-28 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structure of active human telomerase with telomere shelterin protein TPP1.
Nature, 604, 2022
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7TRE
 | | Human telomerase catalytic core with shelterin protein TPP1 | | 分子名称: | Adrenocortical dysplasia protein homolog, Telomerase RNA, partial sequence, ... | | 著者 | Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. | | 登録日 | 2022-01-28 | | 公開日 | 2022-04-20 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure of active human telomerase with telomere shelterin protein TPP1.
Nature, 604, 2022
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7UIN
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7UIM
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