6USR
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7TRD
| Human telomerase catalytic core structure at 3.3 Angstrom | 分子名称: | Telomerase RNA, partial sequence, Telomerase reverse transcriptase, ... | 著者 | Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. | 登録日 | 2022-01-28 | 公開日 | 2022-04-20 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of active human telomerase with telomere shelterin protein TPP1. Nature, 604, 2022
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7TRF
| Human telomerase catalytic core RNP with H2A/H2B | 分子名称: | Histone H2A, Histone H2B type 1-C/E/F/G/I, Telomerase RNA, ... | 著者 | Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. | 登録日 | 2022-01-28 | 公開日 | 2022-04-20 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of active human telomerase with telomere shelterin protein TPP1. Nature, 604, 2022
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7TRE
| Human telomerase catalytic core with shelterin protein TPP1 | 分子名称: | Adrenocortical dysplasia protein homolog, Telomerase RNA, partial sequence, ... | 著者 | Liu, B, He, Y, Wang, Y, Song, H, Zhou, Z.H, Feigon, J. | 登録日 | 2022-01-28 | 公開日 | 2022-04-20 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of active human telomerase with telomere shelterin protein TPP1. Nature, 604, 2022
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7UIM
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7UIN
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7V99
| catalytic core of human telomerase holoenzyme | 分子名称: | Histone H2A type 1-B/E, Histone H2B type 1-K, Primer DNA, ... | 著者 | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | 登録日 | 2021-08-24 | 公開日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Zipper head mechanism of telomere synthesis by human telomerase. Cell Res., 31, 2021
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4OL8
| Ty3 reverse transcriptase bound to DNA/RNA | 分子名称: | 5'-D(*CP*AP*TP*CP*TP*TP*CP*CP*TP*CP*TP*CP*TP*CP*TP*C)-3', 5'-R(*CP*UP*GP*AP*GP*AP*GP*AP*GP*AP*GP*GP*AP*AP*GP*AP*UP*G)-3', Reverse transcriptase/ribonuclease H, ... | 著者 | Nowak, E, Miller, J.T, Bona, M.K, Studnicka, J, Szczepanowski, R.H, Jurkowski, J, Le Grice, S.F.J, Nowotny, M. | 登録日 | 2014-01-23 | 公開日 | 2014-03-05 | 最終更新日 | 2014-04-16 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry. Nat.Struct.Mol.Biol., 21, 2014
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7O0H
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7Q5B
| Cryo-EM structure of Ty3 retrotransposon targeting a TFIIIB-bound tRNA gene | 分子名称: | DNA (19-MER), DNA (31-MER), DNA (34-MER), ... | 著者 | Abascal-Palacios, G, Jochem, L, Pla-Prats, C, Beuron, F, Vannini, A. | 登録日 | 2021-11-03 | 公開日 | 2022-01-26 | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | 主引用文献 | Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes. Nat Commun, 12, 2021
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4KSE
| Crystal structure of a HIV p51 (219-230) deletion mutant | 分子名称: | 1,2-ETHANEDIOL, HIV p51 subunit | 著者 | Zheng, X, Mueller, G.A, Derose, E.F, Pedersen, L.C, Gabel, S.A, Cuneo, M.J, Krahn, J.M, London, R.E. | 登録日 | 2013-05-17 | 公開日 | 2014-08-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.677 Å) | 主引用文献 | Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation. Nucleic Acids Res., 42, 2014
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7QXA
| Cryo-EM map of human telomerase-DNA-TPP1 complex (sharpened) | 分子名称: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | 著者 | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | 登録日 | 2022-01-26 | 公開日 | 2022-03-02 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis of human telomerase recruitment by TPP1-POT1. Science, 375, 2022
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7QXB
| Cryo-EM map of human telomerase-DNA-TPP1-POT1 complex (sharpened map) | 分子名称: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | 著者 | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | 登録日 | 2022-01-26 | 公開日 | 2022-03-02 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (3.91 Å) | 主引用文献 | Structural basis of human telomerase recruitment by TPP1-POT1. Science, 375, 2022
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7QXS
| Cryo-EM structure of human telomerase-DNA-TPP1-POT1 complex (with POT1 side chains) | 分子名称: | Adrenocortical dysplasia homolog (Mouse), isoform CRA_a, Histone H2A, ... | 著者 | Sekne, Z, Ghanim, G.E, van Roon, A.M.M, Nguyen, T.H.D. | 登録日 | 2022-01-27 | 公開日 | 2022-03-02 | 最終更新日 | 2022-03-23 | 実験手法 | ELECTRON MICROSCOPY (3.91 Å) | 主引用文献 | Structural basis of human telomerase recruitment by TPP1-POT1. Science, 375, 2022
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3DU5
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3DU6
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7KFU
| Cas6-RT-Cas1--Cas2 complex | 分子名称: | Cas2, Cas6-RT-Cas1 | 著者 | Hoel, C.M, Wang, J.Y, Doudna, J.A, Brohawn, S.G. | 登録日 | 2020-10-14 | 公開日 | 2021-03-31 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex. Nat Commun, 12, 2021
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7KFT
| Partial Cas6-RT-Cas1--Cas2 complex | 分子名称: | Cas2, Cas6-RT-Cas1 | 著者 | Hoel, C.M, Wang, J.Y, Doudna, J.A, Brohawn, S.G. | 登録日 | 2020-10-14 | 公開日 | 2021-03-31 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex. Nat Commun, 12, 2021
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7K9Y
| GsI-IIC RT Template-Switching Complex (twinned) | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(*CP*TP*CP*CP*AP*GP*GP*CP*AP*AP*C)-3'), MAGNESIUM ION, ... | 著者 | Stamos, J.L, Lentzsch, A.M. | 登録日 | 2020-09-29 | 公開日 | 2021-08-18 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis for template switching by a group II intron-encoded non-LTR-retroelement reverse transcriptase. J.Biol.Chem., 297, 2021
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7KQN
| Ternary complex of TERT (telomerase reverse transcriptase) with RNA template, DNA primer, an incoming dGTP and a downstream hybrid duplex | 分子名称: | 1,2-ETHANEDIOL, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | 著者 | Choi, W.S, Weng, P.J, Yang, W. | 登録日 | 2020-11-17 | 公開日 | 2022-03-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Flexibility of telomerase in binding the RNA template and DNA telomeric repeat. Proc.Natl.Acad.Sci.USA, 119, 2022
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7KQM
| Binary complex of TERT (telomerase reverse transcriptase) with RNA/telomeric DNA hybrid | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*TP*TP*CP*TP*TP*TP*GP*TP*GP*CP*AP*CP*CP*TP*G)-3'), ... | 著者 | Choi, W.S, Weng, P.J, Yang, W. | 登録日 | 2020-11-17 | 公開日 | 2022-03-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Flexibility of telomerase in binding the RNA template and DNA telomeric repeat. Proc.Natl.Acad.Sci.USA, 119, 2022
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3KYL
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8T2S
| Structure of a group II intron ribonucleoprotein in the pre-branching (pre-1F) state | 分子名称: | AMMONIUM ION, CALCIUM ION, Group II intron reverse transcriptase/maturase, ... | 著者 | Xu, L, Liu, T, Chung, K, Pyle, A.M. | 登録日 | 2023-06-06 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into intron catalysis and dynamics during splicing. Nature, 624, 2023
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8T2R
| Structure of a group II intron ribonucleoprotein in the pre-ligation (pre-2F) state | 分子名称: | 5'exon, AMMONIUM ION, CALCIUM ION, ... | 著者 | Xu, L, Liu, T, Chung, K, Pyle, A.M. | 登録日 | 2023-06-06 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into intron catalysis and dynamics during splicing. Nature, 624, 2023
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8T2T
| Structure of a group II intron ribonucleoprotein in the post-ligation (post-2F) state | 分子名称: | AMMONIUM ION, Group II intron reverse transcriptase/maturase, MAGNESIUM ION, ... | 著者 | Xu, L, Liu, T, Chung, K, Pyle, A.M. | 登録日 | 2023-06-06 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into intron catalysis and dynamics during splicing. Nature, 624, 2023
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