6Q13
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![BU of 6q13 by Molmil](/molmil-images/mine/6q13) | CRYSTAL STRUCTURE OF LDHA IN COMPLEX WITH COMPOUND NCGC00420737-09 AT 2.00 A RESOLUTION | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-[5-(cyclopropylmethyl)-4-[(3-fluoro-4-sulfamoylphenyl)methyl]-3-{3-[(5-methylthiophen-2-yl)ethynyl]phenyl}-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid, ... | 著者 | Davies, D.R, Dranow, D.M. | 登録日 | 2019-08-02 | 公開日 | 2020-09-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. J.Med.Chem., 63, 2020
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3P7M
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![BU of 3p7m by Molmil](/molmil-images/mine/3p7m) | Structure of putative lactate dehydrogenase from Francisella tularensis subsp. tularensis SCHU S4 | 分子名称: | Malate dehydrogenase, PHOSPHATE ION | 著者 | Osinski, T, Cymborowski, M, Zimmerman, M.D, Gordon, E, Grimshaw, S, Skarina, T, Chruszcz, M, Savchenko, A, Anderson, W, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2010-10-12 | 公開日 | 2010-10-20 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of putative lactate dehydrogenase from Francisella tularensis subsp. tularensis SCHU S4 To be Published
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5NFR
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![BU of 5nfr by Molmil](/molmil-images/mine/5nfr) | Crystal structure of malate dehydrogenase from Plasmodium falciparum (PfMDH) | 分子名称: | CITRIC ACID, Malate dehydrogenase | 著者 | Lunev, S, Romero, A.R, Batista, F.A, Wrenger, C, Groves, M.R. | 登録日 | 2017-03-15 | 公開日 | 2018-01-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Oligomeric interfaces as a tool in drug discovery: Specific interference with activity of malate dehydrogenase of Plasmodium falciparum in vitro. PLoS ONE, 13, 2018
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2CVQ
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![BU of 2cvq by Molmil](/molmil-images/mine/2cvq) | Crystal structure of NAD(H)-dependent malate dehydrogenase complexed with NADPH | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Malate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Tomita, T, Fushinobu, S, Kuzuyama, T, Nishiyama, M. | 登録日 | 2005-06-13 | 公開日 | 2005-08-02 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Crystal structure of NAD-dependent malate dehydrogenase complexed with NADP(H) Biochem.Biophys.Res.Commun., 334, 2005
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3OM9
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![BU of 3om9 by Molmil](/molmil-images/mine/3om9) | |
4BGV
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![BU of 4bgv by Molmil](/molmil-images/mine/4bgv) | |
4BGU
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![BU of 4bgu by Molmil](/molmil-images/mine/4bgu) | 1.50 A resolution structure of the malate dehydrogenase from Haloferax volcanii | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, CHLORIDE ION, ... | 著者 | Talon, R, Madern, D, Girard, E. | 登録日 | 2013-03-28 | 公開日 | 2014-04-16 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.487 Å) | 主引用文献 | Insight Into Structural Evolution of Extremophilic Proteins To be Published
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3PQE
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![BU of 3pqe by Molmil](/molmil-images/mine/3pqe) | |
2E37
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![BU of 2e37 by Molmil](/molmil-images/mine/2e37) | |
7CGC
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![BU of 7cgc by Molmil](/molmil-images/mine/7cgc) | |
5HTO
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![BU of 5hto by Molmil](/molmil-images/mine/5hto) | |
5HS4
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![BU of 5hs4 by Molmil](/molmil-images/mine/5hs4) | Plasmdoium Vivax Lactate dehydrogenase | 分子名称: | L-lactate dehydrogenase | 著者 | Choi, S.J, Ban, C. | 登録日 | 2016-01-25 | 公開日 | 2016-10-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.339 Å) | 主引用文献 | Crystal structure of a DNA aptamer bound to PvLDH elucidates novel single-stranded DNA structural elements for folding and recognition Sci Rep, 6, 2016
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5HRU
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![BU of 5hru by Molmil](/molmil-images/mine/5hru) | |
1EZ4
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![BU of 1ez4 by Molmil](/molmil-images/mine/1ez4) | CRYSTAL STRUCTURE OF NON-ALLOSTERIC L-LACTATE DEHYDROGENASE FROM LACTOBACILLUS PENTOSUS AT 2.3 ANGSTROM RESOLUTION | 分子名称: | LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Uchikoba, H, Fushinobu, S, Wakagi, T, Konno, M, Taguchi, H, Matsuzawa, H. | 登録日 | 2000-05-10 | 公開日 | 2001-12-28 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of non-allosteric L-lactate dehydrogenase from Lactobacillus pentosus at 2.3 A resolution: specific interactions at subunit interfaces. Proteins, 46, 2002
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7DBJ
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![BU of 7dbj by Molmil](/molmil-images/mine/7dbj) | Crystal structure of human LDHB in complex with NADH, oxamate, and AXKO-0046 | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, L-lactate dehydrogenase B chain, ... | 著者 | Sogabe, S, Miwa, M. | 登録日 | 2020-10-20 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.551 Å) | 主引用文献 | Identification of the first highly selective inhibitor of human lactate dehydrogenase B. Sci Rep, 11, 2021
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7DBK
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![BU of 7dbk by Molmil](/molmil-images/mine/7dbk) | Crystal structure of human LDHB in complex with NADH | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, L-lactate dehydrogenase B chain | 著者 | Sogabe, S, Miwa, M. | 登録日 | 2020-10-20 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | 主引用文献 | Identification of the first highly selective inhibitor of human lactate dehydrogenase B. Sci Rep, 11, 2021
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5IXY
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![BU of 5ixy by Molmil](/molmil-images/mine/5ixy) | Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 31: (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one | 分子名称: | (2~{S})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one, L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Chen, Z, Eigenbrot, C. | 登録日 | 2016-03-23 | 公開日 | 2016-09-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. Acs Med.Chem.Lett., 7, 2016
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1OC4
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![BU of 1oc4 by Molmil](/molmil-images/mine/1oc4) | Lactate dehydrogenase from Plasmodium berghei | 分子名称: | GLYCEROL, L-LACTATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Winter, V.J, Brady, R.L. | 登録日 | 2003-02-05 | 公開日 | 2003-09-18 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of Plasmodium Berghei Lactate Dehydrogenase Indicates the Unique Structural Differences of These Enzymes are Shared Across the Plasmodium Genus Mol.Biochem.Parasitol., 131, 2003
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1PZH
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![BU of 1pzh by Molmil](/molmil-images/mine/1pzh) | |
1PZG
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![BU of 1pzg by Molmil](/molmil-images/mine/1pzg) | |
1PZF
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![BU of 1pzf by Molmil](/molmil-images/mine/1pzf) | |
7CGD
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![BU of 7cgd by Molmil](/molmil-images/mine/7cgd) | Silver-bound E.coli malate dehydrogenase | 分子名称: | Malate dehydrogenase, SILVER ION | 著者 | Wang, H, Wang, M, Sun, H. | 登録日 | 2020-07-01 | 公開日 | 2020-09-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm. Chem Sci, 11, 2020
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5K0Z
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![BU of 5k0z by Molmil](/molmil-images/mine/5k0z) | Cryo-EM structure of lactate dehydrogenase (LDH) in inhibitor-bound state | 分子名称: | L-lactate dehydrogenase B chain | 著者 | Merk, A, Bartesaghi, A, Banerjee, S, Falconieri, V, Rao, P, Earl, L, Milne, J, Subramaniam, S. | 登録日 | 2016-05-17 | 公開日 | 2016-06-08 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery. Cell, 165, 2016
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5IXS
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![BU of 5ixs by Molmil](/molmil-images/mine/5ixs) | Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 9: (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one | 分子名称: | (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one, 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | 著者 | Ultsch, M, Eigenbrot, C. | 登録日 | 2016-03-23 | 公開日 | 2016-09-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. Acs Med.Chem.Lett., 7, 2016
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1GV1
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![BU of 1gv1 by Molmil](/molmil-images/mine/1gv1) | Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases | 分子名称: | MALATE DEHYDROGENASE | 著者 | Dalhus, B, Sarinen, M, Sauer, U.H, Eklund, P, Johansson, K, Karlsson, A, Ramaswamy, S, Bjork, A, Synstad, B, Naterstad, K, Sirevag, R, Eklund, H. | 登録日 | 2002-02-04 | 公開日 | 2002-02-20 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases J.Mol.Biol., 318, 2002
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