7DBJ

Crystal structure of human LDHB in complex with NADH, oxamate, and AXKO-0046

Summary for 7DBJ

Entry DOI	10.2210/pdb7dbj/pdb
Descriptor	L-lactate dehydrogenase B chain, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, OXAMIC ACID, ... (6 entities in total)
Functional Keywords	lactate dehydrogenase, inhibitor, complex, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	150396.37
Authors	Sogabe, S.,Miwa, M. (deposition date: 2020-10-20, release date: 2021-10-20, Last modification date: 2023-11-29)
Primary citation	Shibata, S.,Sogabe, S.,Miwa, M.,Fujimoto, T.,Takakura, N.,Naotsuka, A.,Kitamura, S.,Kawamoto, T.,Soga, T. Identification of the first highly selective inhibitor of human lactate dehydrogenase B. Sci Rep, 11:21353-21353, 2021 Cited by PubMed: 34725423 DOI: 10.1038/s41598-021-00820-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.551 Å)

Structure validation