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7DBJ

Crystal structure of human LDHB in complex with NADH, oxamate, and AXKO-0046

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004457molecular_functionlactate dehydrogenase activity
A0004459molecular_functionL-lactate dehydrogenase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005829cellular_componentcytosol
A0006089biological_processlactate metabolic process
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0019674biological_processNAD metabolic process
A0019752biological_processcarboxylic acid metabolic process
A0019900molecular_functionkinase binding
A0042802molecular_functionidentical protein binding
A0042867biological_processpyruvate catabolic process
A0045121cellular_componentmembrane raft
A0051287molecular_functionNAD binding
A0070062cellular_componentextracellular exosome
A1990204cellular_componentoxidoreductase complex
B0003824molecular_functioncatalytic activity
B0004457molecular_functionlactate dehydrogenase activity
B0004459molecular_functionL-lactate dehydrogenase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0005829cellular_componentcytosol
B0006089biological_processlactate metabolic process
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0019674biological_processNAD metabolic process
B0019752biological_processcarboxylic acid metabolic process
B0019900molecular_functionkinase binding
B0042802molecular_functionidentical protein binding
B0042867biological_processpyruvate catabolic process
B0045121cellular_componentmembrane raft
B0051287molecular_functionNAD binding
B0070062cellular_componentextracellular exosome
B1990204cellular_componentoxidoreductase complex
C0003824molecular_functioncatalytic activity
C0004457molecular_functionlactate dehydrogenase activity
C0004459molecular_functionL-lactate dehydrogenase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005743cellular_componentmitochondrial inner membrane
C0005829cellular_componentcytosol
C0006089biological_processlactate metabolic process
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0019674biological_processNAD metabolic process
C0019752biological_processcarboxylic acid metabolic process
C0019900molecular_functionkinase binding
C0042802molecular_functionidentical protein binding
C0042867biological_processpyruvate catabolic process
C0045121cellular_componentmembrane raft
C0051287molecular_functionNAD binding
C0070062cellular_componentextracellular exosome
C1990204cellular_componentoxidoreductase complex
D0003824molecular_functioncatalytic activity
D0004457molecular_functionlactate dehydrogenase activity
D0004459molecular_functionL-lactate dehydrogenase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005743cellular_componentmitochondrial inner membrane
D0005829cellular_componentcytosol
D0006089biological_processlactate metabolic process
D0016020cellular_componentmembrane
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0019674biological_processNAD metabolic process
D0019752biological_processcarboxylic acid metabolic process
D0019900molecular_functionkinase binding
D0042802molecular_functionidentical protein binding
D0042867biological_processpyruvate catabolic process
D0045121cellular_componentmembrane raft
D0051287molecular_functionNAD binding
D0070062cellular_componentextracellular exosome
D1990204cellular_componentoxidoreductase complex
Functional Information from PROSITE/UniProt
site_idPS00064
Number of Residues7
DetailsL_LDH L-lactate dehydrogenase active site. LGEHGDS
ChainResidueDetails
ALEU191-SER197

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AHIS194
BHIS194
CHIS194
DHIS194

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLN31
BGLN31
CGLN31
DGLN31

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11276087
ChainResidueDetails
AARG100
BARG100
CARG100
DARG100

site_idSWS_FT_FI4
Number of Residues16
DetailsBINDING:
ChainResidueDetails
AARG107
CASN139
CARG170
CTHR249
DARG107
DASN139
DARG170
DTHR249
AASN139
AARG170
ATHR249
BARG107
BASN139
BARG170
BTHR249
CARG107

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.4
ChainResidueDetails
AALA2
BALA2
CALA2
DALA2

site_idSWS_FT_FI6
Number of Residues16
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS7
CLYS58
CLYS119
CLYS329
DLYS7
DLYS58
DLYS119
DLYS329
ALYS58
ALYS119
ALYS329
BLYS7
BLYS58
BLYS119
BLYS329
CLYS7

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ASER44
BSER44
CSER44
DSER44

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231
ChainResidueDetails
ATYR240
BTYR240
CTYR240
DTYR240

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PDB entries from 2025-06-11

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