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1LPW
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BU of 1lpw by Molmil
Solution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridine
分子名称: 5'-R(*GP*GP*UP*GP*(PSU)P*AP*GP*UP*A)-3', 5'-R(*UP*AP*CP*UP*AP*AP*CP*AP*CP*C)-3'
著者Newby, M.I, Greenbaum, N.L.
登録日2002-05-08
公開日2002-11-27
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Sculpting of the Spliceosomal Branch Site Recognition Motif by a Conserved Pseudouridine
Nat.Struct.Biol., 12, 2002
4R3E
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BU of 4r3e by Molmil
Structure of the spliceosomal peptidyl-prolyl cis-trans isomerase Cwc27 from Homo sapiens
分子名称: GLYCEROL, Peptidyl-prolyl cis-trans isomerase CWC27 homolog
著者Ulrich, A, Wahl, M.C.
登録日2014-08-15
公開日2014-11-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure and evolution of the spliceosomal peptidyl-prolyl cis-trans isomerase Cwc27.
Acta Crystallogr.,Sect.D, 70, 2014
2L5J
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BU of 2l5j by Molmil
structure of the spliceosomal phosphopeptide P140 (phosphorylated form)
分子名称: U1 small nuclear ribonucleoprotein 70 kDa
著者Quinternet, M, Page, N, Schall, N, Strub, J, Chaloin, O, Decossas, M, Cung, M, van Dorsselaer, A, Briand, J, Muller, S.
登録日2010-11-02
公開日2010-12-01
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献The spliceosomal phosphopeptide P140 controls the lupus disease by interacting with the HSC70 protein and via a mechanism mediated by gammadelta T cells.
Plos One, 4, 2009
2L5I
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BU of 2l5i by Molmil
structure of the spliceosomal phosphopeptide P140 (non-phosphorylated form)
分子名称: U1 small nuclear ribonucleoprotein 70 kDa
著者Quinternet, M, Page, N, Schall, N, Strub, J, Chaloin, O, Decossas, M, Cung, M, van Dorsselaer, A, Briand, J, Muller, S.
登録日2010-11-02
公開日2010-12-01
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献The spliceosomal phosphopeptide P140 controls the lupus disease by interacting with the HSC70 protein and via a mechanism mediated by gammadelta T cells.
Plos One, 4, 2009
7DCR
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BU of 7dcr by Molmil
cryo-EM structure of the DEAH-box helicase Prp2 in complex with its coactivator Spp2
分子名称: PRP2 isoform 1, Pre-mRNA-splicing factor SPP2
著者Bai, R, Wan, R, Yan, C, Jia, Q, Zhang, P, Lei, J, Shi, Y.
登録日2020-10-26
公開日2021-01-06
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.15 Å)
主引用文献Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2.
Science, 371, 2021
7DD3
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BU of 7dd3 by Molmil
Cryo-EM structure of the pre-mRNA-loaded DEAH-box ATPase/helicase Prp2 in complex with Spp2
分子名称: PRP2 isoform 1, Pre-mRNA-splicing factor SPP2, pre-mRNA
著者Bai, R, Wan, R, Yan, C, Qi, J, Zhang, P, Lei, J, Shi, Y.
登録日2020-10-27
公開日2021-01-06
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2.
Science, 371, 2021
7DCP
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BU of 7dcp by Molmil
cryo-EM structure of the DEAH-box helicase Prp2 and coactivator Spp2
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PRP2 isoform 1, ...
著者Bai, R, Wan, R, Yan, C, Jia, Q, Zhang, P, Lei, J, Shi, Y.
登録日2020-10-26
公開日2021-01-06
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.15 Å)
主引用文献Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2.
Science, 371, 2021
7DCQ
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BU of 7dcq by Molmil
cryo-EM structure of the DEAH-box helicase Prp2
分子名称: PRP2 isoform 1
著者Bai, R, Wan, R, Yan, C, Jia, Q, Zhang, P, Lei, J, Shi, Y.
登録日2020-10-26
公開日2021-01-06
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2.
Science, 371, 2021
6J6H
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BU of 6j6h by Molmil
Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom
分子名称: ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y.
登録日2019-01-15
公開日2019-04-24
最終更新日2020-10-14
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
6J6G
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BU of 6j6g by Molmil
Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom
分子名称: ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y.
登録日2019-01-15
公開日2019-04-24
最終更新日2020-10-14
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
6J6N
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BU of 6j6n by Molmil
Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom
分子名称: GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ...
著者Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y.
登録日2019-01-15
公開日2019-04-24
最終更新日2020-10-14
実験手法ELECTRON MICROSCOPY (3.86 Å)
主引用文献Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
3ZEF
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BU of 3zef by Molmil
Crystal structure of Prp8:Aar2 complex: second crystal form at 3.1 Angstrom resolution
分子名称: A1 CISTRON-SPLICING FACTOR AAR2, PRE-MRNA-SPLICING FACTOR 8
著者Galej, W.P, Oubridge, C, Newman, A.J, Nagai, K.
登録日2012-12-05
公開日2013-01-30
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal Structure of Prp8 Reveals Active Site Cavity of the Spliceosome
Nature, 493, 2013
1B34
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BU of 1b34 by Molmil
CRYSTAL STRUCTURE OF THE D1D2 SUB-COMPLEX FROM THE HUMAN SNRNP CORE DOMAIN
分子名称: PROTEIN (SMALL NUCLEAR RIBONUCLEOPROTEIN SM D1), PROTEIN (SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2)
著者Walke, S, Young, R.J, Kambach, C, Avis, J.M, De La Fortelle, E, Li, J, Nagai, K.
登録日1998-12-17
公開日2000-01-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.
Cell(Cambridge,Mass.), 96, 1999
8QO9
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BU of 8qo9 by Molmil
Cryo-EM structure of a human spliceosomal B complex protomer
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ...
著者Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R.
登録日2023-09-28
公開日2024-01-24
実験手法ELECTRON MICROSCOPY (5.29 Å)
主引用文献New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes
To Be Published
8Q7N
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BU of 8q7n by Molmil
cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region)
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ...
著者Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R.
登録日2023-08-16
公開日2024-01-24
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes
To Be Published
7QTT
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BU of 7qtt by Molmil
Structural organization of a late activated human spliceosome (Baqr, core region)
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ...
著者Cretu, C, Pena, V.
登録日2022-01-15
公開日2023-05-10
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of catalytic activation in human splicing.
Nature, 617, 2023
3SIV
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BU of 3siv by Molmil
Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, dimeric form
分子名称: NHP2-like protein 1, U4/U6 small nuclear ribonucleoprotein Prp31, U4atac snRNA
著者Liu, S, Ghalei, H, Luhrmann, R, Wahl, M.C.
登録日2011-06-20
公開日2011-08-10
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.304 Å)
主引用文献Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31.
Rna, 17, 2011
6J6Q
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BU of 6j6q by Molmil
Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom
分子名称: GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ...
著者Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y.
登録日2019-01-15
公開日2019-04-24
最終更新日2020-10-14
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell, 177, 2019
7VPX
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BU of 7vpx by Molmil
The cryo-EM structure of the human pre-A complex
分子名称: 5SS, DnaJ homolog subfamily C member 8, PHD finger-like domain-containing protein 5A, ...
著者Zhang, X, Zhan, X, Shi, Y.
登録日2021-10-18
公開日2023-05-03
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural insights into branch site proofreading by human spliceosome.
Nat.Struct.Mol.Biol., 2024
8CH6
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BU of 8ch6 by Molmil
Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ...
著者Cretu, C, Schmitzova, J, Pena, V.
登録日2023-02-07
公開日2023-05-10
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (5.9 Å)
主引用文献Structural basis of catalytic activation in human splicing.
Nature, 617, 2023
7Q4O
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BU of 7q4o by Molmil
Substrate-bound A-like U2 snRNP
分子名称: BPS oligo, PHD finger-like domain-containing protein 5A, Splicing factor 3A subunit 2, ...
著者Tholen, J, Galej, W.P.
登録日2021-11-01
公開日2022-03-30
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献Structural basis of branch site recognition by the human spliceosome.
Science, 375, 2022
8R09
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BU of 8r09 by Molmil
Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ...
著者Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
登録日2023-10-31
公開日2024-05-22
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
8RM5
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BU of 8rm5 by Molmil
Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, 5'SS oligo, NHP2-like protein 1, ...
著者Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
登録日2024-01-05
公開日2024-05-22
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (6.9 Å)
主引用文献Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
8R0B
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BU of 8r0b by Molmil
Cryo-EM structure of the cross-exon pre-B+ATP complex
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ...
著者Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
登録日2023-10-31
公開日2024-05-22
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024
8R0A
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BU of 8r0a by Molmil
Cryo-EM structure of the cross-exon pre-B+5'ss complex
分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ...
著者Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R.
登録日2023-10-31
公開日2024-05-22
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (5.8 Å)
主引用文献Structural insights into the cross-exon to cross-intron spliceosome switch.
Nature, 2024

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