Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution.

This is a large structure.

Summary for 6QW6

EMDB information4658
DescriptorU4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein, U4 snRNA, Small nuclear ribonucleoprotein Sm D1, ... (36 entities in total)
Functional Keywordsrnp complex, splicing, rna, protein, spliceosome
Biological sourceHomo sapiens (Human)
Total number of polymer chains39
Total molecular weight1683428.27
Charenton, C.,Wilkinson, M.E.,Nagai, K. (deposition date: 2019-03-05, release date: 2019-04-17, Last modification date: 2019-05-08)
Primary citation
Charenton, C.,Wilkinson, M.E.,Nagai, K.
Mechanism of 5' splice site transfer for human spliceosome activation.
Science, 364:362-367, 2019
PubMed: 30975767 (PDB entries with the same primary citation)
DOI: 10.1126/science.aax3289
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone10 0.4% 1.7% 0.54MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 6qw6
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Molmil generated image of 6qw6
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Molmil generated image of 6qw6
rotated about y axis by 90°