6QW6

Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
41	0000243	cellular_component	commitment complex
41	0000244	biological_process	spliceosomal tri-snRNP complex assembly
41	0000245	biological_process	spliceosomal complex assembly
41	0000387	biological_process	spliceosomal snRNP assembly
41	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
41	0000398	biological_process	mRNA splicing, via spliceosome
41	0003723	molecular_function	RNA binding
41	0005515	molecular_function	protein binding
41	0005634	cellular_component	nucleus
41	0005654	cellular_component	nucleoplasm
41	0005681	cellular_component	spliceosomal complex
41	0005682	cellular_component	U5 snRNP
41	0005684	cellular_component	U2-type spliceosomal complex
41	0005685	cellular_component	U1 snRNP
41	0005686	cellular_component	U2 snRNP
41	0005687	cellular_component	U4 snRNP
41	0005689	cellular_component	U12-type spliceosomal complex
41	0005690	cellular_component	U4atac snRNP
41	0005737	cellular_component	cytoplasm
41	0005829	cellular_component	cytosol
41	0006396	biological_process	RNA processing
41	0006397	biological_process	mRNA processing
41	0008380	biological_process	RNA splicing
41	0030532	cellular_component	small nuclear ribonucleoprotein complex
41	0034693	cellular_component	U11/U12 snRNP
41	0034709	cellular_component	methylosome
41	0034715	cellular_component	pICln-Sm protein complex
41	0034719	cellular_component	SMN-Sm protein complex
41	0036261	biological_process	7-methylguanosine cap hypermethylation
41	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
41	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
41	0071001	cellular_component	U4/U6 snRNP
41	0071002	cellular_component	U4atac/U6atac snRNP
41	0071005	cellular_component	U2-type precatalytic spliceosome
41	0071006	cellular_component	U2-type catalytic step 1 spliceosome
41	0071007	cellular_component	U2-type catalytic step 2 spliceosome
41	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
41	0071011	cellular_component	precatalytic spliceosome
41	0071013	cellular_component	catalytic step 2 spliceosome
41	0071014	cellular_component	post-mRNA release spliceosomal complex
41	0071016	cellular_component	U12-type precatalytic spliceosome
41	0071018	cellular_component	U12-type catalytic step 2 spliceosome
41	0071020	cellular_component	post-spliceosomal complex
41	0097526	cellular_component	spliceosomal tri-snRNP complex
41	1903241	biological_process	U2-type prespliceosome assembly
41	1990446	molecular_function	U1 snRNP binding
41	1990904	cellular_component	ribonucleoprotein complex
42	0000244	biological_process	spliceosomal tri-snRNP complex assembly
42	0000245	biological_process	spliceosomal complex assembly
42	0000387	biological_process	spliceosomal snRNP assembly
42	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
42	0000398	biological_process	mRNA splicing, via spliceosome
42	0003723	molecular_function	RNA binding
42	0005515	molecular_function	protein binding
42	0005634	cellular_component	nucleus
42	0005654	cellular_component	nucleoplasm
42	0005681	cellular_component	spliceosomal complex
42	0005682	cellular_component	U5 snRNP
42	0005684	cellular_component	U2-type spliceosomal complex
42	0005685	cellular_component	U1 snRNP
42	0005686	cellular_component	U2 snRNP
42	0005687	cellular_component	U4 snRNP
42	0005689	cellular_component	U12-type spliceosomal complex
42	0005690	cellular_component	U4atac snRNP
42	0005829	cellular_component	cytosol
42	0006397	biological_process	mRNA processing
42	0008380	biological_process	RNA splicing
42	0030532	cellular_component	small nuclear ribonucleoprotein complex
42	0034693	cellular_component	U11/U12 snRNP
42	0034709	cellular_component	methylosome
42	0034715	cellular_component	pICln-Sm protein complex
42	0034719	cellular_component	SMN-Sm protein complex
42	0036261	biological_process	7-methylguanosine cap hypermethylation
42	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
42	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
42	0070062	cellular_component	extracellular exosome
42	0071001	cellular_component	U4/U6 snRNP
42	0071002	cellular_component	U4atac/U6atac snRNP
42	0071005	cellular_component	U2-type precatalytic spliceosome
42	0071006	cellular_component	U2-type catalytic step 1 spliceosome
42	0071007	cellular_component	U2-type catalytic step 2 spliceosome
42	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
42	0071011	cellular_component	precatalytic spliceosome
42	0071013	cellular_component	catalytic step 2 spliceosome
42	0071014	cellular_component	post-mRNA release spliceosomal complex
42	0071016	cellular_component	U12-type precatalytic spliceosome
42	0071018	cellular_component	U12-type catalytic step 2 spliceosome
42	0071020	cellular_component	post-spliceosomal complex
42	0097525	cellular_component	spliceosomal snRNP complex
42	1903241	biological_process	U2-type prespliceosome assembly
42	1990904	cellular_component	ribonucleoprotein complex
43	0000243	cellular_component	commitment complex
43	0000244	biological_process	spliceosomal tri-snRNP complex assembly
43	0000245	biological_process	spliceosomal complex assembly
43	0000387	biological_process	spliceosomal snRNP assembly
43	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
43	0000398	biological_process	mRNA splicing, via spliceosome
43	0003723	molecular_function	RNA binding
43	0005515	molecular_function	protein binding
43	0005634	cellular_component	nucleus
43	0005654	cellular_component	nucleoplasm
43	0005681	cellular_component	spliceosomal complex
43	0005682	cellular_component	U5 snRNP
43	0005683	cellular_component	U7 snRNP
43	0005684	cellular_component	U2-type spliceosomal complex
43	0005685	cellular_component	U1 snRNP
43	0005686	cellular_component	U2 snRNP
43	0005687	cellular_component	U4 snRNP
43	0005689	cellular_component	U12-type spliceosomal complex
43	0005690	cellular_component	U4atac snRNP
43	0005697	cellular_component	telomerase holoenzyme complex
43	0005737	cellular_component	cytoplasm
43	0005829	cellular_component	cytosol
43	0006396	biological_process	RNA processing
43	0006397	biological_process	mRNA processing
43	0006479	biological_process	protein methylation
43	0008380	biological_process	RNA splicing
43	0016604	cellular_component	nuclear body
43	0019899	molecular_function	enzyme binding
43	0030532	cellular_component	small nuclear ribonucleoprotein complex
43	0034693	cellular_component	U11/U12 snRNP
43	0034709	cellular_component	methylosome
43	0034715	cellular_component	pICln-Sm protein complex
43	0034719	cellular_component	SMN-Sm protein complex
43	0036261	biological_process	7-methylguanosine cap hypermethylation
43	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
43	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
43	0070034	molecular_function	telomerase RNA binding
43	0071001	cellular_component	U4/U6 snRNP
43	0071002	cellular_component	U4atac/U6atac snRNP
43	0071005	cellular_component	U2-type precatalytic spliceosome
43	0071006	cellular_component	U2-type catalytic step 1 spliceosome
43	0071007	cellular_component	U2-type catalytic step 2 spliceosome
43	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
43	0071011	cellular_component	precatalytic spliceosome
43	0071013	cellular_component	catalytic step 2 spliceosome
43	0071014	cellular_component	post-mRNA release spliceosomal complex
43	0071016	cellular_component	U12-type precatalytic spliceosome
43	0071018	cellular_component	U12-type catalytic step 2 spliceosome
43	0071020	cellular_component	post-spliceosomal complex
43	0071045	biological_process	nuclear histone mRNA catabolic process
43	0071208	molecular_function	histone pre-mRNA DCP binding
43	0071209	molecular_function	U7 snRNA binding
43	0097526	cellular_component	spliceosomal tri-snRNP complex
43	1903241	biological_process	U2-type prespliceosome assembly
43	1990904	cellular_component	ribonucleoprotein complex
4A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4A	0000245	biological_process	spliceosomal complex assembly
4A	0000375	biological_process	RNA splicing, via transesterification reactions
4A	0000387	biological_process	spliceosomal snRNP assembly
4A	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4A	0000398	biological_process	mRNA splicing, via spliceosome
4A	0003723	molecular_function	RNA binding
4A	0005515	molecular_function	protein binding
4A	0005634	cellular_component	nucleus
4A	0005654	cellular_component	nucleoplasm
4A	0005681	cellular_component	spliceosomal complex
4A	0005687	cellular_component	U4 snRNP
4A	0005690	cellular_component	U4atac snRNP
4A	0006397	biological_process	mRNA processing
4A	0008380	biological_process	RNA splicing
4A	0015030	cellular_component	Cajal body
4A	0016607	cellular_component	nuclear speck
4A	0042802	molecular_function	identical protein binding
4A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4A	0071001	cellular_component	U4/U6 snRNP
4A	0071002	cellular_component	U4atac/U6atac snRNP
4A	0071005	cellular_component	U2-type precatalytic spliceosome
4A	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
4A	0071011	cellular_component	precatalytic spliceosome
4A	0071016	cellular_component	U12-type precatalytic spliceosome
4B	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4B	0000245	biological_process	spliceosomal complex assembly
4B	0000375	biological_process	RNA splicing, via transesterification reactions
4B	0000387	biological_process	spliceosomal snRNP assembly
4B	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4B	0000398	biological_process	mRNA splicing, via spliceosome
4B	0005515	molecular_function	protein binding
4B	0005634	cellular_component	nucleus
4B	0005654	cellular_component	nucleoplasm
4B	0005681	cellular_component	spliceosomal complex
4B	0005687	cellular_component	U4 snRNP
4B	0005690	cellular_component	U4atac snRNP
4B	0006396	biological_process	RNA processing
4B	0006397	biological_process	mRNA processing
4B	0008380	biological_process	RNA splicing
4B	0015030	cellular_component	Cajal body
4B	0016607	cellular_component	nuclear speck
4B	0017070	molecular_function	U6 snRNA binding
4B	0030621	molecular_function	U4 snRNA binding
4B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4B	0071001	cellular_component	U4/U6 snRNP
4B	0071002	cellular_component	U4atac/U6atac snRNP
4B	0071005	cellular_component	U2-type precatalytic spliceosome
4B	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
4B	0071011	cellular_component	precatalytic spliceosome
4B	0071016	cellular_component	U12-type precatalytic spliceosome
4B	0097525	cellular_component	spliceosomal snRNP complex
4C	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4C	0000387	biological_process	spliceosomal snRNP assembly
4C	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4C	0000398	biological_process	mRNA splicing, via spliceosome
4C	0003723	molecular_function	RNA binding
4C	0005515	molecular_function	protein binding
4C	0005634	cellular_component	nucleus
4C	0005654	cellular_component	nucleoplasm
4C	0005681	cellular_component	spliceosomal complex
4C	0005684	cellular_component	U2-type spliceosomal complex
4C	0005687	cellular_component	U4 snRNP
4C	0005690	cellular_component	U4atac snRNP
4C	0006397	biological_process	mRNA processing
4C	0008380	biological_process	RNA splicing
4C	0015030	cellular_component	Cajal body
4C	0016607	cellular_component	nuclear speck
4C	0030621	molecular_function	U4 snRNA binding
4C	0030622	molecular_function	U4atac snRNA binding
4C	0030674	molecular_function	protein-macromolecule adaptor activity
4C	0042802	molecular_function	identical protein binding
4C	0043021	molecular_function	ribonucleoprotein complex binding
4C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4C	0048254	biological_process	snoRNA localization
4C	0070990	molecular_function	snRNP binding
4C	0071001	cellular_component	U4/U6 snRNP
4C	0071002	cellular_component	U4atac/U6atac snRNP
4C	0071005	cellular_component	U2-type precatalytic spliceosome
4C	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
4C	0071011	cellular_component	precatalytic spliceosome
4C	0071016	cellular_component	U12-type precatalytic spliceosome
4C	0071166	biological_process	ribonucleoprotein complex localization
4C	0071339	cellular_component	MLL1 complex
4C	0097526	cellular_component	spliceosomal tri-snRNP complex
4C	1990904	cellular_component	ribonucleoprotein complex
4D	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4D	0000245	biological_process	spliceosomal complex assembly
4D	0000387	biological_process	spliceosomal snRNP assembly
4D	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4D	0000398	biological_process	mRNA splicing, via spliceosome
4D	0000451	biological_process	rRNA 2'-O-methylation
4D	0000492	biological_process	box C/D snoRNP assembly
4D	0001651	cellular_component	dense fibrillar component
4D	0003723	molecular_function	RNA binding
4D	0005515	molecular_function	protein binding
4D	0005634	cellular_component	nucleus
4D	0005654	cellular_component	nucleoplasm
4D	0005681	cellular_component	spliceosomal complex
4D	0005687	cellular_component	U4 snRNP
4D	0005690	cellular_component	U4atac snRNP
4D	0005730	cellular_component	nucleolus
4D	0006397	biological_process	mRNA processing
4D	0008380	biological_process	RNA splicing
4D	0016556	biological_process	mRNA modification
4D	0030182	biological_process	neuron differentiation
4D	0030490	biological_process	maturation of SSU-rRNA
4D	0030515	molecular_function	snoRNA binding
4D	0030621	molecular_function	U4 snRNA binding
4D	0030622	molecular_function	U4atac snRNA binding
4D	0031428	cellular_component	box C/D methylation guide snoRNP complex
4D	0032040	cellular_component	small-subunit processome
4D	0032991	cellular_component	protein-containing complex
4D	0034511	molecular_function	U3 snoRNA binding
4D	0034512	molecular_function	box C/D sno(s)RNA binding
4D	0042254	biological_process	ribosome biogenesis
4D	0042274	biological_process	ribosomal small subunit biogenesis
4D	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4D	0051117	molecular_function	ATPase binding
4D	0071001	cellular_component	U4/U6 snRNP
4D	0071002	cellular_component	U4atac/U6atac snRNP
4D	0071005	cellular_component	U2-type precatalytic spliceosome
4D	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
4D	0071011	cellular_component	precatalytic spliceosome
4D	0071016	cellular_component	U12-type precatalytic spliceosome
4D	1990904	cellular_component	ribonucleoprotein complex
4b	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4b	0000245	biological_process	spliceosomal complex assembly
4b	0000387	biological_process	spliceosomal snRNP assembly
4b	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4b	0000398	biological_process	mRNA splicing, via spliceosome
4b	0003723	molecular_function	RNA binding
4b	0005515	molecular_function	protein binding
4b	0005634	cellular_component	nucleus
4b	0005654	cellular_component	nucleoplasm
4b	0005681	cellular_component	spliceosomal complex
4b	0005682	cellular_component	U5 snRNP
4b	0005683	cellular_component	U7 snRNP
4b	0005684	cellular_component	U2-type spliceosomal complex
4b	0005685	cellular_component	U1 snRNP
4b	0005686	cellular_component	U2 snRNP
4b	0005687	cellular_component	U4 snRNP
4b	0005689	cellular_component	U12-type spliceosomal complex
4b	0005690	cellular_component	U4atac snRNP
4b	0005697	cellular_component	telomerase holoenzyme complex
4b	0005737	cellular_component	cytoplasm
4b	0005829	cellular_component	cytosol
4b	0006397	biological_process	mRNA processing
4b	0006479	biological_process	protein methylation
4b	0008380	biological_process	RNA splicing
4b	0030532	cellular_component	small nuclear ribonucleoprotein complex
4b	0034693	cellular_component	U11/U12 snRNP
4b	0034709	cellular_component	methylosome
4b	0034719	cellular_component	SMN-Sm protein complex
4b	0036261	biological_process	7-methylguanosine cap hypermethylation
4b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4b	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
4b	0070034	molecular_function	telomerase RNA binding
4b	0070990	molecular_function	snRNP binding
4b	0071001	cellular_component	U4/U6 snRNP
4b	0071002	cellular_component	U4atac/U6atac snRNP
4b	0071004	cellular_component	U2-type prespliceosome
4b	0071005	cellular_component	U2-type precatalytic spliceosome
4b	0071006	cellular_component	U2-type catalytic step 1 spliceosome
4b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
4b	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
4b	0071011	cellular_component	precatalytic spliceosome
4b	0071013	cellular_component	catalytic step 2 spliceosome
4b	0071014	cellular_component	post-mRNA release spliceosomal complex
4b	0071016	cellular_component	U12-type precatalytic spliceosome
4b	0071018	cellular_component	U12-type catalytic step 2 spliceosome
4b	0071020	cellular_component	post-spliceosomal complex
4b	0071045	biological_process	nuclear histone mRNA catabolic process
4b	0071204	cellular_component	histone pre-mRNA 3'end processing complex
4b	0071208	molecular_function	histone pre-mRNA DCP binding
4b	1903241	biological_process	U2-type prespliceosome assembly
4b	1990446	molecular_function	U1 snRNP binding
4b	1990447	molecular_function	U2 snRNP binding
4b	1990904	cellular_component	ribonucleoprotein complex
4e	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4e	0000245	biological_process	spliceosomal complex assembly
4e	0000387	biological_process	spliceosomal snRNP assembly
4e	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4e	0000398	biological_process	mRNA splicing, via spliceosome
4e	0003723	molecular_function	RNA binding
4e	0005515	molecular_function	protein binding
4e	0005634	cellular_component	nucleus
4e	0005654	cellular_component	nucleoplasm
4e	0005681	cellular_component	spliceosomal complex
4e	0005682	cellular_component	U5 snRNP
4e	0005683	cellular_component	U7 snRNP
4e	0005684	cellular_component	U2-type spliceosomal complex
4e	0005685	cellular_component	U1 snRNP
4e	0005686	cellular_component	U2 snRNP
4e	0005687	cellular_component	U4 snRNP
4e	0005689	cellular_component	U12-type spliceosomal complex
4e	0005690	cellular_component	U4atac snRNP
4e	0005697	cellular_component	telomerase holoenzyme complex
4e	0005829	cellular_component	cytosol
4e	0006397	biological_process	mRNA processing
4e	0008380	biological_process	RNA splicing
4e	0030532	cellular_component	small nuclear ribonucleoprotein complex
4e	0034693	cellular_component	U11/U12 snRNP
4e	0034709	cellular_component	methylosome
4e	0034715	cellular_component	pICln-Sm protein complex
4e	0034719	cellular_component	SMN-Sm protein complex
4e	0036261	biological_process	7-methylguanosine cap hypermethylation
4e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4e	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
4e	0071001	cellular_component	U4/U6 snRNP
4e	0071002	cellular_component	U4atac/U6atac snRNP
4e	0071005	cellular_component	U2-type precatalytic spliceosome
4e	0071006	cellular_component	U2-type catalytic step 1 spliceosome
4e	0071007	cellular_component	U2-type catalytic step 2 spliceosome
4e	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
4e	0071011	cellular_component	precatalytic spliceosome
4e	0071013	cellular_component	catalytic step 2 spliceosome
4e	0071014	cellular_component	post-mRNA release spliceosomal complex
4e	0071016	cellular_component	U12-type precatalytic spliceosome
4e	0071018	cellular_component	U12-type catalytic step 2 spliceosome
4e	0071020	cellular_component	post-spliceosomal complex
4e	0071045	biological_process	nuclear histone mRNA catabolic process
4e	1903241	biological_process	U2-type prespliceosome assembly
4e	1990904	cellular_component	ribonucleoprotein complex
4f	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4f	0000245	biological_process	spliceosomal complex assembly
4f	0000387	biological_process	spliceosomal snRNP assembly
4f	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4f	0000398	biological_process	mRNA splicing, via spliceosome
4f	0003723	molecular_function	RNA binding
4f	0005515	molecular_function	protein binding
4f	0005634	cellular_component	nucleus
4f	0005654	cellular_component	nucleoplasm
4f	0005681	cellular_component	spliceosomal complex
4f	0005682	cellular_component	U5 snRNP
4f	0005683	cellular_component	U7 snRNP
4f	0005684	cellular_component	U2-type spliceosomal complex
4f	0005685	cellular_component	U1 snRNP
4f	0005686	cellular_component	U2 snRNP
4f	0005687	cellular_component	U4 snRNP
4f	0005689	cellular_component	U12-type spliceosomal complex
4f	0005690	cellular_component	U4atac snRNP
4f	0005829	cellular_component	cytosol
4f	0006397	biological_process	mRNA processing
4f	0008380	biological_process	RNA splicing
4f	0022618	biological_process	protein-RNA complex assembly
4f	0030532	cellular_component	small nuclear ribonucleoprotein complex
4f	0034693	cellular_component	U11/U12 snRNP
4f	0034709	cellular_component	methylosome
4f	0034715	cellular_component	pICln-Sm protein complex
4f	0034719	cellular_component	SMN-Sm protein complex
4f	0036261	biological_process	7-methylguanosine cap hypermethylation
4f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4f	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
4f	0071001	cellular_component	U4/U6 snRNP
4f	0071002	cellular_component	U4atac/U6atac snRNP
4f	0071005	cellular_component	U2-type precatalytic spliceosome
4f	0071006	cellular_component	U2-type catalytic step 1 spliceosome
4f	0071007	cellular_component	U2-type catalytic step 2 spliceosome
4f	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
4f	0071011	cellular_component	precatalytic spliceosome
4f	0071013	cellular_component	catalytic step 2 spliceosome
4f	0071014	cellular_component	post-mRNA release spliceosomal complex
4f	0071016	cellular_component	U12-type precatalytic spliceosome
4f	0071018	cellular_component	U12-type catalytic step 2 spliceosome
4f	0071020	cellular_component	post-spliceosomal complex
4f	0071045	biological_process	nuclear histone mRNA catabolic process
4f	1903241	biological_process	U2-type prespliceosome assembly
4f	1990904	cellular_component	ribonucleoprotein complex
4g	0000244	biological_process	spliceosomal tri-snRNP complex assembly
4g	0000245	biological_process	spliceosomal complex assembly
4g	0000387	biological_process	spliceosomal snRNP assembly
4g	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
4g	0000398	biological_process	mRNA splicing, via spliceosome
4g	0003723	molecular_function	RNA binding
4g	0005515	molecular_function	protein binding
4g	0005634	cellular_component	nucleus
4g	0005654	cellular_component	nucleoplasm
4g	0005681	cellular_component	spliceosomal complex
4g	0005682	cellular_component	U5 snRNP
4g	0005683	cellular_component	U7 snRNP
4g	0005684	cellular_component	U2-type spliceosomal complex
4g	0005685	cellular_component	U1 snRNP
4g	0005686	cellular_component	U2 snRNP
4g	0005687	cellular_component	U4 snRNP
4g	0005689	cellular_component	U12-type spliceosomal complex
4g	0005690	cellular_component	U4atac snRNP
4g	0005829	cellular_component	cytosol
4g	0006397	biological_process	mRNA processing
4g	0008380	biological_process	RNA splicing
4g	0030532	cellular_component	small nuclear ribonucleoprotein complex
4g	0034693	cellular_component	U11/U12 snRNP
4g	0034709	cellular_component	methylosome
4g	0034719	cellular_component	SMN-Sm protein complex
4g	0036261	biological_process	7-methylguanosine cap hypermethylation
4g	0043186	cellular_component	P granule
4g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
4g	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
4g	0071001	cellular_component	U4/U6 snRNP
4g	0071002	cellular_component	U4atac/U6atac snRNP
4g	0071004	cellular_component	U2-type prespliceosome
4g	0071005	cellular_component	U2-type precatalytic spliceosome
4g	0071006	cellular_component	U2-type catalytic step 1 spliceosome
4g	0071007	cellular_component	U2-type catalytic step 2 spliceosome
4g	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
4g	0071011	cellular_component	precatalytic spliceosome
4g	0071013	cellular_component	catalytic step 2 spliceosome
4g	0071014	cellular_component	post-mRNA release spliceosomal complex
4g	0071016	cellular_component	U12-type precatalytic spliceosome
4g	0071018	cellular_component	U12-type catalytic step 2 spliceosome
4g	0071020	cellular_component	post-spliceosomal complex
4g	0071045	biological_process	nuclear histone mRNA catabolic process
4g	0097526	cellular_component	spliceosomal tri-snRNP complex
4g	1903241	biological_process	U2-type prespliceosome assembly
4g	1990904	cellular_component	ribonucleoprotein complex
51	0000243	cellular_component	commitment complex
51	0000244	biological_process	spliceosomal tri-snRNP complex assembly
51	0000245	biological_process	spliceosomal complex assembly
51	0000387	biological_process	spliceosomal snRNP assembly
51	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
51	0000398	biological_process	mRNA splicing, via spliceosome
51	0003723	molecular_function	RNA binding
51	0005515	molecular_function	protein binding
51	0005634	cellular_component	nucleus
51	0005654	cellular_component	nucleoplasm
51	0005681	cellular_component	spliceosomal complex
51	0005682	cellular_component	U5 snRNP
51	0005684	cellular_component	U2-type spliceosomal complex
51	0005685	cellular_component	U1 snRNP
51	0005686	cellular_component	U2 snRNP
51	0005687	cellular_component	U4 snRNP
51	0005689	cellular_component	U12-type spliceosomal complex
51	0005690	cellular_component	U4atac snRNP
51	0005737	cellular_component	cytoplasm
51	0005829	cellular_component	cytosol
51	0006396	biological_process	RNA processing
51	0006397	biological_process	mRNA processing
51	0008380	biological_process	RNA splicing
51	0030532	cellular_component	small nuclear ribonucleoprotein complex
51	0034693	cellular_component	U11/U12 snRNP
51	0034709	cellular_component	methylosome
51	0034715	cellular_component	pICln-Sm protein complex
51	0034719	cellular_component	SMN-Sm protein complex
51	0036261	biological_process	7-methylguanosine cap hypermethylation
51	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
51	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
51	0071001	cellular_component	U4/U6 snRNP
51	0071002	cellular_component	U4atac/U6atac snRNP
51	0071005	cellular_component	U2-type precatalytic spliceosome
51	0071006	cellular_component	U2-type catalytic step 1 spliceosome
51	0071007	cellular_component	U2-type catalytic step 2 spliceosome
51	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
51	0071011	cellular_component	precatalytic spliceosome
51	0071013	cellular_component	catalytic step 2 spliceosome
51	0071014	cellular_component	post-mRNA release spliceosomal complex
51	0071016	cellular_component	U12-type precatalytic spliceosome
51	0071018	cellular_component	U12-type catalytic step 2 spliceosome
51	0071020	cellular_component	post-spliceosomal complex
51	0097526	cellular_component	spliceosomal tri-snRNP complex
51	1903241	biological_process	U2-type prespliceosome assembly
51	1990446	molecular_function	U1 snRNP binding
51	1990904	cellular_component	ribonucleoprotein complex
52	0000244	biological_process	spliceosomal tri-snRNP complex assembly
52	0000245	biological_process	spliceosomal complex assembly
52	0000387	biological_process	spliceosomal snRNP assembly
52	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
52	0000398	biological_process	mRNA splicing, via spliceosome
52	0003723	molecular_function	RNA binding
52	0005515	molecular_function	protein binding
52	0005634	cellular_component	nucleus
52	0005654	cellular_component	nucleoplasm
52	0005681	cellular_component	spliceosomal complex
52	0005682	cellular_component	U5 snRNP
52	0005684	cellular_component	U2-type spliceosomal complex
52	0005685	cellular_component	U1 snRNP
52	0005686	cellular_component	U2 snRNP
52	0005687	cellular_component	U4 snRNP
52	0005689	cellular_component	U12-type spliceosomal complex
52	0005690	cellular_component	U4atac snRNP
52	0005829	cellular_component	cytosol
52	0006397	biological_process	mRNA processing
52	0008380	biological_process	RNA splicing
52	0030532	cellular_component	small nuclear ribonucleoprotein complex
52	0034693	cellular_component	U11/U12 snRNP
52	0034709	cellular_component	methylosome
52	0034715	cellular_component	pICln-Sm protein complex
52	0034719	cellular_component	SMN-Sm protein complex
52	0036261	biological_process	7-methylguanosine cap hypermethylation
52	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
52	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
52	0070062	cellular_component	extracellular exosome
52	0071001	cellular_component	U4/U6 snRNP
52	0071002	cellular_component	U4atac/U6atac snRNP
52	0071005	cellular_component	U2-type precatalytic spliceosome
52	0071006	cellular_component	U2-type catalytic step 1 spliceosome
52	0071007	cellular_component	U2-type catalytic step 2 spliceosome
52	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
52	0071011	cellular_component	precatalytic spliceosome
52	0071013	cellular_component	catalytic step 2 spliceosome
52	0071014	cellular_component	post-mRNA release spliceosomal complex
52	0071016	cellular_component	U12-type precatalytic spliceosome
52	0071018	cellular_component	U12-type catalytic step 2 spliceosome
52	0071020	cellular_component	post-spliceosomal complex
52	0097525	cellular_component	spliceosomal snRNP complex
52	1903241	biological_process	U2-type prespliceosome assembly
52	1990904	cellular_component	ribonucleoprotein complex
53	0000243	cellular_component	commitment complex
53	0000244	biological_process	spliceosomal tri-snRNP complex assembly
53	0000245	biological_process	spliceosomal complex assembly
53	0000387	biological_process	spliceosomal snRNP assembly
53	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
53	0000398	biological_process	mRNA splicing, via spliceosome
53	0003723	molecular_function	RNA binding
53	0005515	molecular_function	protein binding
53	0005634	cellular_component	nucleus
53	0005654	cellular_component	nucleoplasm
53	0005681	cellular_component	spliceosomal complex
53	0005682	cellular_component	U5 snRNP
53	0005683	cellular_component	U7 snRNP
53	0005684	cellular_component	U2-type spliceosomal complex
53	0005685	cellular_component	U1 snRNP
53	0005686	cellular_component	U2 snRNP
53	0005687	cellular_component	U4 snRNP
53	0005689	cellular_component	U12-type spliceosomal complex
53	0005690	cellular_component	U4atac snRNP
53	0005697	cellular_component	telomerase holoenzyme complex
53	0005737	cellular_component	cytoplasm
53	0005829	cellular_component	cytosol
53	0006396	biological_process	RNA processing
53	0006397	biological_process	mRNA processing
53	0006479	biological_process	protein methylation
53	0008380	biological_process	RNA splicing
53	0016604	cellular_component	nuclear body
53	0019899	molecular_function	enzyme binding
53	0030532	cellular_component	small nuclear ribonucleoprotein complex
53	0034693	cellular_component	U11/U12 snRNP
53	0034709	cellular_component	methylosome
53	0034715	cellular_component	pICln-Sm protein complex
53	0034719	cellular_component	SMN-Sm protein complex
53	0036261	biological_process	7-methylguanosine cap hypermethylation
53	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
53	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
53	0070034	molecular_function	telomerase RNA binding
53	0071001	cellular_component	U4/U6 snRNP
53	0071002	cellular_component	U4atac/U6atac snRNP
53	0071005	cellular_component	U2-type precatalytic spliceosome
53	0071006	cellular_component	U2-type catalytic step 1 spliceosome
53	0071007	cellular_component	U2-type catalytic step 2 spliceosome
53	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
53	0071011	cellular_component	precatalytic spliceosome
53	0071013	cellular_component	catalytic step 2 spliceosome
53	0071014	cellular_component	post-mRNA release spliceosomal complex
53	0071016	cellular_component	U12-type precatalytic spliceosome
53	0071018	cellular_component	U12-type catalytic step 2 spliceosome
53	0071020	cellular_component	post-spliceosomal complex
53	0071045	biological_process	nuclear histone mRNA catabolic process
53	0071208	molecular_function	histone pre-mRNA DCP binding
53	0071209	molecular_function	U7 snRNA binding
53	0097526	cellular_component	spliceosomal tri-snRNP complex
53	1903241	biological_process	U2-type prespliceosome assembly
53	1990904	cellular_component	ribonucleoprotein complex
5A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5A	0000375	biological_process	RNA splicing, via transesterification reactions
5A	0000387	biological_process	spliceosomal snRNP assembly
5A	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5A	0000398	biological_process	mRNA splicing, via spliceosome
5A	0003723	molecular_function	RNA binding
5A	0005515	molecular_function	protein binding
5A	0005634	cellular_component	nucleus
5A	0005654	cellular_component	nucleoplasm
5A	0005681	cellular_component	spliceosomal complex
5A	0005682	cellular_component	U5 snRNP
5A	0006397	biological_process	mRNA processing
5A	0008233	molecular_function	peptidase activity
5A	0008237	molecular_function	metallopeptidase activity
5A	0008380	biological_process	RNA splicing
5A	0016020	cellular_component	membrane
5A	0016607	cellular_component	nuclear speck
5A	0017070	molecular_function	U6 snRNA binding
5A	0030532	cellular_component	small nuclear ribonucleoprotein complex
5A	0030619	molecular_function	U1 snRNA binding
5A	0030620	molecular_function	U2 snRNA binding
5A	0030623	molecular_function	U5 snRNA binding
5A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5A	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
5A	0070530	molecular_function	K63-linked polyubiquitin modification-dependent protein binding
5A	0071005	cellular_component	U2-type precatalytic spliceosome
5A	0071006	cellular_component	U2-type catalytic step 1 spliceosome
5A	0071007	cellular_component	U2-type catalytic step 2 spliceosome
5A	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
5A	0071011	cellular_component	precatalytic spliceosome
5A	0071013	cellular_component	catalytic step 2 spliceosome
5A	0071014	cellular_component	post-mRNA release spliceosomal complex
5A	0071016	cellular_component	U12-type precatalytic spliceosome
5A	0071018	cellular_component	U12-type catalytic step 2 spliceosome
5A	0071020	cellular_component	post-spliceosomal complex
5A	0071222	biological_process	cellular response to lipopolysaccharide
5A	0071356	biological_process	cellular response to tumor necrosis factor
5A	0097157	molecular_function	pre-mRNA intronic binding
5A	0140492	molecular_function	metal-dependent deubiquitinase activity
5A	1990904	cellular_component	ribonucleoprotein complex
5B	0000166	molecular_function	nucleotide binding
5B	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5B	0000354	biological_process	cis assembly of pre-catalytic spliceosome
5B	0000387	biological_process	spliceosomal snRNP assembly
5B	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5B	0000398	biological_process	mRNA splicing, via spliceosome
5B	0001649	biological_process	osteoblast differentiation
5B	0003676	molecular_function	nucleic acid binding
5B	0003723	molecular_function	RNA binding
5B	0003724	molecular_function	RNA helicase activity
5B	0004386	molecular_function	helicase activity
5B	0005515	molecular_function	protein binding
5B	0005524	molecular_function	ATP binding
5B	0005634	cellular_component	nucleus
5B	0005654	cellular_component	nucleoplasm
5B	0005681	cellular_component	spliceosomal complex
5B	0005682	cellular_component	U5 snRNP
5B	0006397	biological_process	mRNA processing
5B	0008380	biological_process	RNA splicing
5B	0016020	cellular_component	membrane
5B	0016787	molecular_function	hydrolase activity
5B	0016887	molecular_function	ATP hydrolysis activity
5B	0030532	cellular_component	small nuclear ribonucleoprotein complex
5B	0042802	molecular_function	identical protein binding
5B	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5B	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
5B	0071005	cellular_component	U2-type precatalytic spliceosome
5B	0071006	cellular_component	U2-type catalytic step 1 spliceosome
5B	0071007	cellular_component	U2-type catalytic step 2 spliceosome
5B	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
5B	0071011	cellular_component	precatalytic spliceosome
5B	0071013	cellular_component	catalytic step 2 spliceosome
5B	0071016	cellular_component	U12-type precatalytic spliceosome
5B	0071018	cellular_component	U12-type catalytic step 2 spliceosome
5B	0071020	cellular_component	post-spliceosomal complex
5C	0003924	molecular_function	GTPase activity
5C	0005525	molecular_function	GTP binding
5D	0000245	biological_process	spliceosomal complex assembly
5D	0000375	biological_process	RNA splicing, via transesterification reactions
5D	0000387	biological_process	spliceosomal snRNP assembly
5D	0000398	biological_process	mRNA splicing, via spliceosome
5D	0005515	molecular_function	protein binding
5D	0005634	cellular_component	nucleus
5D	0005654	cellular_component	nucleoplasm
5D	0005681	cellular_component	spliceosomal complex
5D	0005682	cellular_component	U5 snRNP
5D	0006397	biological_process	mRNA processing
5D	0008380	biological_process	RNA splicing
5D	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5D	0051301	biological_process	cell division
5D	0071005	cellular_component	U2-type precatalytic spliceosome
5D	0071011	cellular_component	precatalytic spliceosome
5J	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5J	0000245	biological_process	spliceosomal complex assembly
5J	0000375	biological_process	RNA splicing, via transesterification reactions
5J	0000387	biological_process	spliceosomal snRNP assembly
5J	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5J	0000398	biological_process	mRNA splicing, via spliceosome
5J	0003723	molecular_function	RNA binding
5J	0005515	molecular_function	protein binding
5J	0005634	cellular_component	nucleus
5J	0005654	cellular_component	nucleoplasm
5J	0005681	cellular_component	spliceosomal complex
5J	0005682	cellular_component	U5 snRNP
5J	0006396	biological_process	RNA processing
5J	0006397	biological_process	mRNA processing
5J	0006403	biological_process	RNA localization
5J	0008380	biological_process	RNA splicing
5J	0016020	cellular_component	membrane
5J	0016607	cellular_component	nuclear speck
5J	0030674	molecular_function	protein-macromolecule adaptor activity
5J	0042802	molecular_function	identical protein binding
5J	0043021	molecular_function	ribonucleoprotein complex binding
5J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
5J	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5J	0071005	cellular_component	U2-type precatalytic spliceosome
5J	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
5J	0071011	cellular_component	precatalytic spliceosome
5J	0071013	cellular_component	catalytic step 2 spliceosome
5J	0071016	cellular_component	U12-type precatalytic spliceosome
5O	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5O	0000375	biological_process	RNA splicing, via transesterification reactions
5O	0000387	biological_process	spliceosomal snRNP assembly
5O	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5O	0000398	biological_process	mRNA splicing, via spliceosome
5O	0003723	molecular_function	RNA binding
5O	0005515	molecular_function	protein binding
5O	0005634	cellular_component	nucleus
5O	0005654	cellular_component	nucleoplasm
5O	0005681	cellular_component	spliceosomal complex
5O	0005682	cellular_component	U5 snRNP
5O	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
5O	0006396	biological_process	RNA processing
5O	0006397	biological_process	mRNA processing
5O	0008380	biological_process	RNA splicing
5O	0016607	cellular_component	nuclear speck
5O	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5O	0071006	cellular_component	U2-type catalytic step 1 spliceosome
5O	0071007	cellular_component	U2-type catalytic step 2 spliceosome
5O	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
5O	0071011	cellular_component	precatalytic spliceosome
5O	0071013	cellular_component	catalytic step 2 spliceosome
5O	0071014	cellular_component	post-mRNA release spliceosomal complex
5O	0071016	cellular_component	U12-type precatalytic spliceosome
5O	0071018	cellular_component	U12-type catalytic step 2 spliceosome
5O	0071020	cellular_component	post-spliceosomal complex
5X	0000166	molecular_function	nucleotide binding
5X	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5X	0000354	biological_process	cis assembly of pre-catalytic spliceosome
5X	0000375	biological_process	RNA splicing, via transesterification reactions
5X	0000387	biological_process	spliceosomal snRNP assembly
5X	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5X	0000398	biological_process	mRNA splicing, via spliceosome
5X	0000785	cellular_component	chromatin
5X	0003676	molecular_function	nucleic acid binding
5X	0003723	molecular_function	RNA binding
5X	0003724	molecular_function	RNA helicase activity
5X	0003729	molecular_function	mRNA binding
5X	0004386	molecular_function	helicase activity
5X	0005515	molecular_function	protein binding
5X	0005524	molecular_function	ATP binding
5X	0005634	cellular_component	nucleus
5X	0005654	cellular_component	nucleoplasm
5X	0005681	cellular_component	spliceosomal complex
5X	0005682	cellular_component	U5 snRNP
5X	0005694	cellular_component	chromosome
5X	0005730	cellular_component	nucleolus
5X	0006397	biological_process	mRNA processing
5X	0008380	biological_process	RNA splicing
5X	0016787	molecular_function	hydrolase activity
5X	0016887	molecular_function	ATP hydrolysis activity
5X	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5X	0062176	biological_process	R-loop processing
5X	0070062	cellular_component	extracellular exosome
5X	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
5X	0071011	cellular_component	precatalytic spliceosome
5X	0071013	cellular_component	catalytic step 2 spliceosome
5X	0071016	cellular_component	U12-type precatalytic spliceosome
5b	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5b	0000245	biological_process	spliceosomal complex assembly
5b	0000387	biological_process	spliceosomal snRNP assembly
5b	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5b	0000398	biological_process	mRNA splicing, via spliceosome
5b	0003723	molecular_function	RNA binding
5b	0005515	molecular_function	protein binding
5b	0005634	cellular_component	nucleus
5b	0005654	cellular_component	nucleoplasm
5b	0005681	cellular_component	spliceosomal complex
5b	0005682	cellular_component	U5 snRNP
5b	0005683	cellular_component	U7 snRNP
5b	0005684	cellular_component	U2-type spliceosomal complex
5b	0005685	cellular_component	U1 snRNP
5b	0005686	cellular_component	U2 snRNP
5b	0005687	cellular_component	U4 snRNP
5b	0005689	cellular_component	U12-type spliceosomal complex
5b	0005690	cellular_component	U4atac snRNP
5b	0005697	cellular_component	telomerase holoenzyme complex
5b	0005737	cellular_component	cytoplasm
5b	0005829	cellular_component	cytosol
5b	0006397	biological_process	mRNA processing
5b	0006479	biological_process	protein methylation
5b	0008380	biological_process	RNA splicing
5b	0030532	cellular_component	small nuclear ribonucleoprotein complex
5b	0034693	cellular_component	U11/U12 snRNP
5b	0034709	cellular_component	methylosome
5b	0034719	cellular_component	SMN-Sm protein complex
5b	0036261	biological_process	7-methylguanosine cap hypermethylation
5b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5b	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
5b	0070034	molecular_function	telomerase RNA binding
5b	0070990	molecular_function	snRNP binding
5b	0071001	cellular_component	U4/U6 snRNP
5b	0071002	cellular_component	U4atac/U6atac snRNP
5b	0071004	cellular_component	U2-type prespliceosome
5b	0071005	cellular_component	U2-type precatalytic spliceosome
5b	0071006	cellular_component	U2-type catalytic step 1 spliceosome
5b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
5b	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
5b	0071011	cellular_component	precatalytic spliceosome
5b	0071013	cellular_component	catalytic step 2 spliceosome
5b	0071014	cellular_component	post-mRNA release spliceosomal complex
5b	0071016	cellular_component	U12-type precatalytic spliceosome
5b	0071018	cellular_component	U12-type catalytic step 2 spliceosome
5b	0071020	cellular_component	post-spliceosomal complex
5b	0071045	biological_process	nuclear histone mRNA catabolic process
5b	0071204	cellular_component	histone pre-mRNA 3'end processing complex
5b	0071208	molecular_function	histone pre-mRNA DCP binding
5b	1903241	biological_process	U2-type prespliceosome assembly
5b	1990446	molecular_function	U1 snRNP binding
5b	1990447	molecular_function	U2 snRNP binding
5b	1990904	cellular_component	ribonucleoprotein complex
5e	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5e	0000245	biological_process	spliceosomal complex assembly
5e	0000387	biological_process	spliceosomal snRNP assembly
5e	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5e	0000398	biological_process	mRNA splicing, via spliceosome
5e	0003723	molecular_function	RNA binding
5e	0005515	molecular_function	protein binding
5e	0005634	cellular_component	nucleus
5e	0005654	cellular_component	nucleoplasm
5e	0005681	cellular_component	spliceosomal complex
5e	0005682	cellular_component	U5 snRNP
5e	0005683	cellular_component	U7 snRNP
5e	0005684	cellular_component	U2-type spliceosomal complex
5e	0005685	cellular_component	U1 snRNP
5e	0005686	cellular_component	U2 snRNP
5e	0005687	cellular_component	U4 snRNP
5e	0005689	cellular_component	U12-type spliceosomal complex
5e	0005690	cellular_component	U4atac snRNP
5e	0005697	cellular_component	telomerase holoenzyme complex
5e	0005829	cellular_component	cytosol
5e	0006397	biological_process	mRNA processing
5e	0008380	biological_process	RNA splicing
5e	0030532	cellular_component	small nuclear ribonucleoprotein complex
5e	0034693	cellular_component	U11/U12 snRNP
5e	0034709	cellular_component	methylosome
5e	0034715	cellular_component	pICln-Sm protein complex
5e	0034719	cellular_component	SMN-Sm protein complex
5e	0036261	biological_process	7-methylguanosine cap hypermethylation
5e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5e	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
5e	0071001	cellular_component	U4/U6 snRNP
5e	0071002	cellular_component	U4atac/U6atac snRNP
5e	0071005	cellular_component	U2-type precatalytic spliceosome
5e	0071006	cellular_component	U2-type catalytic step 1 spliceosome
5e	0071007	cellular_component	U2-type catalytic step 2 spliceosome
5e	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
5e	0071011	cellular_component	precatalytic spliceosome
5e	0071013	cellular_component	catalytic step 2 spliceosome
5e	0071014	cellular_component	post-mRNA release spliceosomal complex
5e	0071016	cellular_component	U12-type precatalytic spliceosome
5e	0071018	cellular_component	U12-type catalytic step 2 spliceosome
5e	0071020	cellular_component	post-spliceosomal complex
5e	0071045	biological_process	nuclear histone mRNA catabolic process
5e	1903241	biological_process	U2-type prespliceosome assembly
5e	1990904	cellular_component	ribonucleoprotein complex
5f	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5f	0000245	biological_process	spliceosomal complex assembly
5f	0000387	biological_process	spliceosomal snRNP assembly
5f	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5f	0000398	biological_process	mRNA splicing, via spliceosome
5f	0003723	molecular_function	RNA binding
5f	0005515	molecular_function	protein binding
5f	0005634	cellular_component	nucleus
5f	0005654	cellular_component	nucleoplasm
5f	0005681	cellular_component	spliceosomal complex
5f	0005682	cellular_component	U5 snRNP
5f	0005683	cellular_component	U7 snRNP
5f	0005684	cellular_component	U2-type spliceosomal complex
5f	0005685	cellular_component	U1 snRNP
5f	0005686	cellular_component	U2 snRNP
5f	0005687	cellular_component	U4 snRNP
5f	0005689	cellular_component	U12-type spliceosomal complex
5f	0005690	cellular_component	U4atac snRNP
5f	0005829	cellular_component	cytosol
5f	0006397	biological_process	mRNA processing
5f	0008380	biological_process	RNA splicing
5f	0022618	biological_process	protein-RNA complex assembly
5f	0030532	cellular_component	small nuclear ribonucleoprotein complex
5f	0034693	cellular_component	U11/U12 snRNP
5f	0034709	cellular_component	methylosome
5f	0034715	cellular_component	pICln-Sm protein complex
5f	0034719	cellular_component	SMN-Sm protein complex
5f	0036261	biological_process	7-methylguanosine cap hypermethylation
5f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5f	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
5f	0071001	cellular_component	U4/U6 snRNP
5f	0071002	cellular_component	U4atac/U6atac snRNP
5f	0071005	cellular_component	U2-type precatalytic spliceosome
5f	0071006	cellular_component	U2-type catalytic step 1 spliceosome
5f	0071007	cellular_component	U2-type catalytic step 2 spliceosome
5f	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
5f	0071011	cellular_component	precatalytic spliceosome
5f	0071013	cellular_component	catalytic step 2 spliceosome
5f	0071014	cellular_component	post-mRNA release spliceosomal complex
5f	0071016	cellular_component	U12-type precatalytic spliceosome
5f	0071018	cellular_component	U12-type catalytic step 2 spliceosome
5f	0071020	cellular_component	post-spliceosomal complex
5f	0071045	biological_process	nuclear histone mRNA catabolic process
5f	1903241	biological_process	U2-type prespliceosome assembly
5f	1990904	cellular_component	ribonucleoprotein complex
5g	0000244	biological_process	spliceosomal tri-snRNP complex assembly
5g	0000245	biological_process	spliceosomal complex assembly
5g	0000387	biological_process	spliceosomal snRNP assembly
5g	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
5g	0000398	biological_process	mRNA splicing, via spliceosome
5g	0003723	molecular_function	RNA binding
5g	0005515	molecular_function	protein binding
5g	0005634	cellular_component	nucleus
5g	0005654	cellular_component	nucleoplasm
5g	0005681	cellular_component	spliceosomal complex
5g	0005682	cellular_component	U5 snRNP
5g	0005683	cellular_component	U7 snRNP
5g	0005684	cellular_component	U2-type spliceosomal complex
5g	0005685	cellular_component	U1 snRNP
5g	0005686	cellular_component	U2 snRNP
5g	0005687	cellular_component	U4 snRNP
5g	0005689	cellular_component	U12-type spliceosomal complex
5g	0005690	cellular_component	U4atac snRNP
5g	0005829	cellular_component	cytosol
5g	0006397	biological_process	mRNA processing
5g	0008380	biological_process	RNA splicing
5g	0030532	cellular_component	small nuclear ribonucleoprotein complex
5g	0034693	cellular_component	U11/U12 snRNP
5g	0034709	cellular_component	methylosome
5g	0034719	cellular_component	SMN-Sm protein complex
5g	0036261	biological_process	7-methylguanosine cap hypermethylation
5g	0043186	cellular_component	P granule
5g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
5g	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
5g	0071001	cellular_component	U4/U6 snRNP
5g	0071002	cellular_component	U4atac/U6atac snRNP
5g	0071004	cellular_component	U2-type prespliceosome
5g	0071005	cellular_component	U2-type precatalytic spliceosome
5g	0071006	cellular_component	U2-type catalytic step 1 spliceosome
5g	0071007	cellular_component	U2-type catalytic step 2 spliceosome
5g	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
5g	0071011	cellular_component	precatalytic spliceosome
5g	0071013	cellular_component	catalytic step 2 spliceosome
5g	0071014	cellular_component	post-mRNA release spliceosomal complex
5g	0071016	cellular_component	U12-type precatalytic spliceosome
5g	0071018	cellular_component	U12-type catalytic step 2 spliceosome
5g	0071020	cellular_component	post-spliceosomal complex
5g	0071045	biological_process	nuclear histone mRNA catabolic process
5g	0097526	cellular_component	spliceosomal tri-snRNP complex
5g	1903241	biological_process	U2-type prespliceosome assembly
5g	1990904	cellular_component	ribonucleoprotein complex
62	0000244	biological_process	spliceosomal tri-snRNP complex assembly
62	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
62	0000387	biological_process	spliceosomal snRNP assembly
62	0000398	biological_process	mRNA splicing, via spliceosome
62	0000932	cellular_component	P-body
62	0003723	molecular_function	RNA binding
62	0005634	cellular_component	nucleus
62	0005654	cellular_component	nucleoplasm
62	0005681	cellular_component	spliceosomal complex
62	0005688	cellular_component	U6 snRNP
62	0005691	cellular_component	U6atac snRNP
62	0005737	cellular_component	cytoplasm
62	0005829	cellular_component	cytosol
62	0006397	biological_process	mRNA processing
62	0006402	biological_process	mRNA catabolic process
62	0008380	biological_process	RNA splicing
62	0017070	molecular_function	U6 snRNA binding
62	0031267	molecular_function	small GTPase binding
62	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
62	0071001	cellular_component	U4/U6 snRNP
62	0071002	cellular_component	U4atac/U6atac snRNP
62	0071005	cellular_component	U2-type precatalytic spliceosome
62	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
62	0071011	cellular_component	precatalytic spliceosome
62	0071013	cellular_component	catalytic step 2 spliceosome
62	0120115	cellular_component	Lsm2-8 complex
62	1990726	cellular_component	Lsm1-7-Pat1 complex
62	1990904	cellular_component	ribonucleoprotein complex
63	0000244	biological_process	spliceosomal tri-snRNP complex assembly
63	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
63	0000387	biological_process	spliceosomal snRNP assembly
63	0000398	biological_process	mRNA splicing, via spliceosome
63	0000932	cellular_component	P-body
63	0003723	molecular_function	RNA binding
63	0005515	molecular_function	protein binding
63	0005634	cellular_component	nucleus
63	0005654	cellular_component	nucleoplasm
63	0005681	cellular_component	spliceosomal complex
63	0005688	cellular_component	U6 snRNP
63	0005691	cellular_component	U6atac snRNP
63	0005737	cellular_component	cytoplasm
63	0005829	cellular_component	cytosol
63	0006397	biological_process	mRNA processing
63	0008380	biological_process	RNA splicing
63	0030629	molecular_function	U6 snRNA 3'-end binding
63	0033962	biological_process	P-body assembly
63	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
63	0071001	cellular_component	U4/U6 snRNP
63	0071002	cellular_component	U4atac/U6atac snRNP
63	0071005	cellular_component	U2-type precatalytic spliceosome
63	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
63	0071011	cellular_component	precatalytic spliceosome
63	0071013	cellular_component	catalytic step 2 spliceosome
63	0120115	cellular_component	Lsm2-8 complex
63	1990726	cellular_component	Lsm1-7-Pat1 complex
63	1990904	cellular_component	ribonucleoprotein complex
64	0000244	biological_process	spliceosomal tri-snRNP complex assembly
64	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
64	0000387	biological_process	spliceosomal snRNP assembly
64	0000398	biological_process	mRNA splicing, via spliceosome
64	0000932	cellular_component	P-body
64	0000956	biological_process	nuclear-transcribed mRNA catabolic process
64	0003723	molecular_function	RNA binding
64	0005515	molecular_function	protein binding
64	0005634	cellular_component	nucleus
64	0005654	cellular_component	nucleoplasm
64	0005681	cellular_component	spliceosomal complex
64	0005688	cellular_component	U6 snRNP
64	0005691	cellular_component	U6atac snRNP
64	0005737	cellular_component	cytoplasm
64	0005829	cellular_component	cytosol
64	0006396	biological_process	RNA processing
64	0006397	biological_process	mRNA processing
64	0008380	biological_process	RNA splicing
64	0016020	cellular_component	membrane
64	0017070	molecular_function	U6 snRNA binding
64	0032991	cellular_component	protein-containing complex
64	0033962	biological_process	P-body assembly
64	0042731	molecular_function	PH domain binding
64	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
64	0071001	cellular_component	U4/U6 snRNP
64	0071002	cellular_component	U4atac/U6atac snRNP
64	0071005	cellular_component	U2-type precatalytic spliceosome
64	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
64	0071011	cellular_component	precatalytic spliceosome
64	0097526	cellular_component	spliceosomal tri-snRNP complex
64	0120115	cellular_component	Lsm2-8 complex
64	1990726	cellular_component	Lsm1-7-Pat1 complex
64	1990904	cellular_component	ribonucleoprotein complex
65	0000244	biological_process	spliceosomal tri-snRNP complex assembly
65	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
65	0000387	biological_process	spliceosomal snRNP assembly
65	0000398	biological_process	mRNA splicing, via spliceosome
65	0003723	molecular_function	RNA binding
65	0005634	cellular_component	nucleus
65	0005654	cellular_component	nucleoplasm
65	0005681	cellular_component	spliceosomal complex
65	0005688	cellular_component	U6 snRNP
65	0005691	cellular_component	U6atac snRNP
65	0005737	cellular_component	cytoplasm
65	0005829	cellular_component	cytosol
65	0006397	biological_process	mRNA processing
65	0006402	biological_process	mRNA catabolic process
65	0008380	biological_process	RNA splicing
65	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
65	0046982	molecular_function	protein heterodimerization activity
65	0071001	cellular_component	U4/U6 snRNP
65	0071002	cellular_component	U4atac/U6atac snRNP
65	0071005	cellular_component	U2-type precatalytic spliceosome
65	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
65	0071011	cellular_component	precatalytic spliceosome
65	0120115	cellular_component	Lsm2-8 complex
65	1990726	cellular_component	Lsm1-7-Pat1 complex
65	1990904	cellular_component	ribonucleoprotein complex
66	0000244	biological_process	spliceosomal tri-snRNP complex assembly
66	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
66	0000387	biological_process	spliceosomal snRNP assembly
66	0000398	biological_process	mRNA splicing, via spliceosome
66	0000932	cellular_component	P-body
66	0003723	molecular_function	RNA binding
66	0005515	molecular_function	protein binding
66	0005634	cellular_component	nucleus
66	0005654	cellular_component	nucleoplasm
66	0005681	cellular_component	spliceosomal complex
66	0005688	cellular_component	U6 snRNP
66	0005691	cellular_component	U6atac snRNP
66	0005730	cellular_component	nucleolus
66	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
66	0005737	cellular_component	cytoplasm
66	0005829	cellular_component	cytosol
66	0006364	biological_process	rRNA processing
66	0006397	biological_process	mRNA processing
66	0006402	biological_process	mRNA catabolic process
66	0008033	biological_process	tRNA processing
66	0008380	biological_process	RNA splicing
66	0030490	biological_process	maturation of SSU-rRNA
66	0030532	cellular_component	small nuclear ribonucleoprotein complex
66	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
66	0046982	molecular_function	protein heterodimerization activity
66	0071001	cellular_component	U4/U6 snRNP
66	0071002	cellular_component	U4atac/U6atac snRNP
66	0071005	cellular_component	U2-type precatalytic spliceosome
66	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
66	0071011	cellular_component	precatalytic spliceosome
66	0120115	cellular_component	Lsm2-8 complex
66	1990726	cellular_component	Lsm1-7-Pat1 complex
66	1990904	cellular_component	ribonucleoprotein complex
67	0000244	biological_process	spliceosomal tri-snRNP complex assembly
67	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
67	0000387	biological_process	spliceosomal snRNP assembly
67	0000398	biological_process	mRNA splicing, via spliceosome
67	0000956	biological_process	nuclear-transcribed mRNA catabolic process
67	0003723	molecular_function	RNA binding
67	0005515	molecular_function	protein binding
67	0005634	cellular_component	nucleus
67	0005654	cellular_component	nucleoplasm
67	0005681	cellular_component	spliceosomal complex
67	0005688	cellular_component	U6 snRNP
67	0005689	cellular_component	U12-type spliceosomal complex
67	0005691	cellular_component	U6atac snRNP
67	0005737	cellular_component	cytoplasm
67	0005829	cellular_component	cytosol
67	0006397	biological_process	mRNA processing
67	0008380	biological_process	RNA splicing
67	0017070	molecular_function	U6 snRNA binding
67	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
67	0071001	cellular_component	U4/U6 snRNP
67	0071002	cellular_component	U4atac/U6atac snRNP
67	0071004	cellular_component	U2-type prespliceosome
67	0071005	cellular_component	U2-type precatalytic spliceosome
67	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
67	0071011	cellular_component	precatalytic spliceosome
67	0071013	cellular_component	catalytic step 2 spliceosome
67	0097526	cellular_component	spliceosomal tri-snRNP complex
67	0120115	cellular_component	Lsm2-8 complex
67	1990726	cellular_component	Lsm1-7-Pat1 complex
67	1990904	cellular_component	ribonucleoprotein complex
68	0000244	biological_process	spliceosomal tri-snRNP complex assembly
68	0000387	biological_process	spliceosomal snRNP assembly
68	0000398	biological_process	mRNA splicing, via spliceosome
68	0003723	molecular_function	RNA binding
68	0003729	molecular_function	mRNA binding
68	0005515	molecular_function	protein binding
68	0005634	cellular_component	nucleus
68	0005654	cellular_component	nucleoplasm
68	0005681	cellular_component	spliceosomal complex
68	0005688	cellular_component	U6 snRNP
68	0005691	cellular_component	U6atac snRNP
68	0006397	biological_process	mRNA processing
68	0008380	biological_process	RNA splicing
68	0017070	molecular_function	U6 snRNA binding
68	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
68	0071001	cellular_component	U4/U6 snRNP
68	0071002	cellular_component	U4atac/U6atac snRNP
68	0071005	cellular_component	U2-type precatalytic spliceosome
68	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
68	0071011	cellular_component	precatalytic spliceosome
68	0120115	cellular_component	Lsm2-8 complex
68	1990904	cellular_component	ribonucleoprotein complex
R	0000387	biological_process	spliceosomal snRNP assembly
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0003676	molecular_function	nucleic acid binding
R	0003723	molecular_function	RNA binding
R	0003729	molecular_function	mRNA binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005681	cellular_component	spliceosomal complex
R	0005737	cellular_component	cytoplasm
R	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
R	0071011	cellular_component	precatalytic spliceosome
S	0000244	biological_process	spliceosomal tri-snRNP complex assembly
S	0000387	biological_process	spliceosomal snRNP assembly
S	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0000481	biological_process	maturation of 5S rRNA
S	0003723	molecular_function	RNA binding
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005681	cellular_component	spliceosomal complex
S	0005737	cellular_component	cytoplasm
S	0005794	cellular_component	Golgi apparatus
S	0005829	cellular_component	cytosol
S	0006397	biological_process	mRNA processing
S	0008380	biological_process	RNA splicing
S	0015030	cellular_component	Cajal body
S	0016607	cellular_component	nuclear speck
S	0045292	biological_process	mRNA cis splicing, via spliceosome
S	0045585	biological_process	positive regulation of cytotoxic T cell differentiation
S	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
S	0071005	cellular_component	U2-type precatalytic spliceosome
S	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
S	0071011	cellular_component	precatalytic spliceosome
S	0071013	cellular_component	catalytic step 2 spliceosome
S	0071016	cellular_component	U12-type precatalytic spliceosome
U	0000244	biological_process	spliceosomal tri-snRNP complex assembly
U	0000245	biological_process	spliceosomal complex assembly
U	0000387	biological_process	spliceosomal snRNP assembly
U	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
U	0000398	biological_process	mRNA splicing, via spliceosome
U	0004843	molecular_function	cysteine-type deubiquitinase activity
U	0005515	molecular_function	protein binding
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005681	cellular_component	spliceosomal complex
U	0006397	biological_process	mRNA processing
U	0008270	molecular_function	zinc ion binding
U	0008380	biological_process	RNA splicing
U	0016579	biological_process	protein deubiquitination
U	0016787	molecular_function	hydrolase activity
U	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
U	0046872	molecular_function	metal ion binding
U	0051301	biological_process	cell division
U	0071009	cellular_component	U4atac/U6atac x U5 tri-snRNP complex
U	0071011	cellular_component	precatalytic spliceosome
U	0071016	cellular_component	U12-type precatalytic spliceosome
X	0000387	biological_process	spliceosomal snRNP assembly
X	0000398	biological_process	mRNA splicing, via spliceosome
X	0003676	molecular_function	nucleic acid binding
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005681	cellular_component	spliceosomal complex
X	0006397	biological_process	mRNA processing
X	0008380	biological_process	RNA splicing
X	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
X	0071011	cellular_component	precatalytic spliceosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue IHP 5A 2401

Chain	Residue
5A	ARG163
5A	LYS623
5A	GLY624
5X	GLU275
5A	LYS442
5A	HIS584
5A	LYS606
5A	LYS609
5A	HIS610
5A	TYR613
5A	TYR614
5A	ASN617

---

site_id	AC2
Number of Residues	3
Details	binding site for residue MG 5C 2601

Chain	Residue
5C	THR143
5C	ASP204
5C	GTP2602

---

site_id	AC3
Number of Residues	23
Details	binding site for residue GTP 5C 2602

Chain	Residue
5A	PRO335
5C	LEU138
5C	HIS139
5C	HIS140
5C	GLY141
5C	LYS142
5C	THR143
5C	CYS144
5C	ASP164
5C	GLY178
5C	VAL179
5C	GLY180
5C	GLY207
5C	HIS208
5C	ASN258
5C	LYS259
5C	ASP261
5C	ARG262
5C	GLU266
5C	SER311
5C	SER312
5C	GLN313
5C	MG2601

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN U 600

Chain	Residue
U	CYS136
U	CYS139
U	HIS155
U	HIS161

---

site_id	AC5
Number of Residues	12
Details	binding site for Di-peptide PHE R 404 and ASP R 434

Chain	Residue
R	PHE401
R	SER402
R	ARG403
R	PRO405
R	SER406
R	ASP431
R	PRO432
R	SER433
R	TYR435
R	VAL436
R	ARG437
R	ALA438

---

site_id	AC6
Number of Residues	10
Details	binding site for Di-peptide PRO R 405 and ASP R 434

Chain	Residue
R	PHE404
R	SER406
R	LEU408
R	ASP431
R	PRO432
R	SER433
R	TYR435
R	VAL436
R	ARG437
R	ALA438

---

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADRmI

Chain	Residue	Details
5X	VAL547-ILE555

---

site_id	PS00436
Number of Residues	12
Details	PEROXIDASE_2 Peroxidases active site signature. TVrvARVmWHPS

Chain	Residue	Details
4B	THR323-SER334

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LGTTcyDrSWRLWDL

Chain	Residue	Details
4B	LEU338-LEU352
4B	ILE422-LEU436
5O	LEU81-VAL95
5O	LEU124-SER138
5O	VAL167-ILE181
5O	ILE208-LEU222
5O	ILE300-THR314

---

site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CedknVPYvfVrSKqaLG

Chain	Residue	Details
4D	CYS73-GLY90

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	581
Details	Domain: {"description":"Sm","evidences":[{"source":"PROSITE-ProRule","id":"PRU01346","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	78
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	86
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	79
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	78
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	78
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	79
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	63
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	34
Details	Coiled coil: {"evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	13
Details	Motif: {"description":"Nuclear localization signal (NLS)","evidences":[{"source":"PubMed","id":"12444105","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Site: {"description":"Interaction with U4 snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	3
Details	Site: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Site: {"description":"Interaction with U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	12
Details	Region: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21784869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	32
Details	Region: {"description":"Important for U4 snRNA-binding","evidences":[{"source":"PubMed","id":"10545122","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Site: {"description":"Interaction with U4 snRNA and U4atac snRNA","evidences":[{"source":"PubMed","id":"17412961","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21784869","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D0T1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	131
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	491
Details	Region: {"description":"Reverse transcriptase homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	13
Details	Region: {"description":"Important for branch point selection","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	171
Details	Region: {"description":"Restriction endonuclease homology domain"}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	34
Details	Region: {"description":"Required for interaction with EFTUD2 and SNRNP200","evidences":[{"source":"PubMed","id":"17317632","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	1
Details	Modified residue: {"description":"N6,N6-dimethyllysine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	183
Details	Domain: {"description":"Helicase ATP-binding 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	237
Details	Domain: {"description":"Helicase C-terminal 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	305
Details	Domain: {"description":"SEC63 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	175
Details	Domain: {"description":"Helicase ATP-binding 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	208
Details	Domain: {"description":"Helicase C-terminal 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	312
Details	Domain: {"description":"SEC63 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	30
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	30
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	3
Details	Motif: {"description":"DEIH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	3
Details	Motif: {"description":"DEVH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23045696","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4F93","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"F1LNJ2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q6P4T2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	282
Details	Domain: {"description":"tr-type G","evidences":[{"source":"PROSITE-ProRule","id":"PRU01059","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	32
Details	Repeat: {"description":"HAT 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI49
Number of Residues	26
Details	Repeat: {"description":"HAT 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI50
Number of Residues	31
Details	Repeat: {"description":"HAT 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI51
Number of Residues	32
Details	Repeat: {"description":"HAT 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI52
Number of Residues	32
Details	Repeat: {"description":"HAT 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI53
Number of Residues	32
Details	Repeat: {"description":"HAT 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI54
Number of Residues	32
Details	Repeat: {"description":"HAT 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI55
Number of Residues	32
Details	Repeat: {"description":"HAT 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI56
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI57
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI58
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI59
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI60
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI61
Number of Residues	28
Details	Motif: {"description":"Q motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00552","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI62
Number of Residues	3
Details	Motif: {"description":"DEAD box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI63
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI64
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI65
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI66
Number of Residues	78
Details	Domain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI67
Number of Residues	330
Details	Domain: {"description":"USP"}

Chain

Residue

Details

---

site_id	SWS_FT_FI68
Number of Residues	97
Details	Zinc finger: {"description":"UBP-type; degenerate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00502","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI69
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00502","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---