2MH0
 
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3EB1
 | | Crystal structure PTP1B complex with small molecule inhibitor LZP-25 | | 分子名称: | 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid, Tyrosine-protein phosphatase non-receptor type 1 | | 著者 | Liu, S, Zheng, L.-F, Wu, L, Yu, X, Xue, T, Gunawan, A.M, Long, Y.-Q, Zhang, Z.-Y. | | 登録日 | 2008-08-26 | | 公開日 | 2009-07-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors.
J.Am.Chem.Soc., 130, 2008
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4EJ0
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5Y2D
 | | Crystal structure of H. pylori HtrA | | 分子名称: | Periplasmic serine endoprotease DegP-like, UNK-UNK-K-UNK-UNK-UNK-UNK-UNK-UNK-UNK, UNK-UNK-UNK, ... | | 著者 | Zhang, Z, Huang, Q, Tao, X. | | 登録日 | 2017-07-25 | | 公開日 | 2018-08-15 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.70009851 Å) | | 主引用文献 | The unique trimeric assembly of the virulence factor HtrA fromHelicobacter pylorioccurs via N-terminal domain swapping.
J.Biol.Chem., 294, 2019
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4XEY
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3ETW
 | | Crystal Structure of bacterial adhesin FadA | | 分子名称: | Adhesin A, THIOCYANATE ION | | 著者 | Nithianantham, S, Xu, M, Wu, N, Shoham, M, Han, Y.W. | | 登録日 | 2008-10-08 | | 公開日 | 2008-12-02 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of FadA Adhesin from Fusobacterium nucleatum Reveals a Novel Oligomerization Motif, the Leucine Chain.
J.Biol.Chem., 284, 2009
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3ETY
 | | Crystal structure of bacterial adhesin FadA L14A mutant | | 分子名称: | Adhesin A | | 著者 | Nithianantham, S, Xu, M, Wu, N, Shoham, M, Han, Y.W. | | 登録日 | 2008-10-08 | | 公開日 | 2008-12-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal Structure of FadA Adhesin from Fusobacterium nucleatum Reveals a Novel Oligomerization Motif, the Leucine Chain.
J.Biol.Chem., 284, 2009
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3O26
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3E22
 | | Tubulin-colchicine-soblidotin: Stathmin-like domain complex | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Cormier, A, Marchand, M, Ravelli, R.B, Knossow, M, Gigant, B. | | 登録日 | 2008-08-05 | | 公開日 | 2008-10-21 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Structural insight into the inhibition of tubulin by vinca domain peptide ligands
Embo Rep., 9, 2008
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3ELA
 | | Crystal structure of active site inhibited coagulation factor VIIA mutant in complex with soluble tissue factor | | 分子名称: | CALCIUM ION, Coagulation factor VIIA heavy chain, Coagulation factor VIIA light chain, ... | | 著者 | Bjelke, J.R, Fodje, M, Svensson, L.A. | | 登録日 | 2008-09-21 | | 公開日 | 2008-11-04 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Mechanism of the Ca2+-induced enhancement of the intrinsic factor VIIa activity
J.Biol.Chem., 283, 2008
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4D1J
 | | The structure of the GH35 beta-galactosidase Bgl35A from Cellvibrio japonicas in complex with 1-Deoxygalactonojirimycin | | 分子名称: | (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, ACETATE ION, BETA-GALACTOSIDASE, ... | | 著者 | Larsbrink, J, Thompson, A.J, Lundqvist, M, Gardner, J.G, Davies, G.J, Brumer, H. | | 登録日 | 2014-05-02 | | 公開日 | 2014-05-28 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A Complex Gene Locus Enables Xyloglucan Utilization in the Model Saprophyte Cellvibrio Japonicus.
Mol.Microbiol., 94, 2014
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2M1N
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3EMW
 | | Crystal Structure of human splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2) in complex with a 20-residue VASA peptide | | 分子名称: | 1,2-ETHANEDIOL, Peptide (VASA), SPRY domain-containing SOCS box protein 2 | | 著者 | Filippakopoulos, P, Sharpe, T, Keates, T, Murray, J.W, Savitsky, P, Roos, A.K, Pike, A.C.W, Von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Bullock, A, Structural Genomics Consortium (SGC) | | 登録日 | 2008-09-25 | | 公開日 | 2008-10-28 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
J.Mol.Biol., 401, 2010
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2M1X
 | | TICAM-1 TIR domain structure | | 分子名称: | TIR domain-containing adapter molecule 1 | | 著者 | Enokizono, Y, Kumeta, H, Funami, K, Horiuchi, M, Sarmiento, J, Yamashita, K, Standley, D.M, Matsumoto, M, Seya, T, Inagaki, F. | | 登録日 | 2012-12-07 | | 公開日 | 2014-01-15 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling.
Proc.Natl.Acad.Sci.USA, 110, 2013
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3NWO
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4BVG
 | | CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH NATIVE ALKYLIMIDATE FORMED FROM ACETYL-LYSINE ACS2-PEPTIDE CRYSTALLIZED IN PRESENCE OF THE INHIBITOR EX-527 | | 分子名称: | (2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL ACETATE, 1,2-ETHANEDIOL, ACETYL-COENZYME A SYNTHETASE 2-LIKE, ... | | 著者 | Nguyen, G.T.T, Gertz, M, Weyand, M, Steegborn, C. | | 登録日 | 2013-06-25 | | 公開日 | 2013-07-17 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.
Proc. Natl. Acad. Sci. U.S.A., 110, 2013
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3NY2
 | | Structure of the ubr-box of UBR2 ubiquitin ligase | | 分子名称: | E3 ubiquitin-protein ligase UBR2, ZINC ION | | 著者 | Matta-Camacho, E, Kozlov, G, Li, F, Gehring, K. | | 登録日 | 2010-07-14 | | 公開日 | 2010-08-11 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Structural basis of substrate recognition and specificity in the N-end rule pathway.
Nat.Struct.Mol.Biol., 17, 2010
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5F9F
 | | Crystal structure of RIG-I helicase-RD in complex with 24-mer blunt-end hairpin RNA | | 分子名称: | (R,R)-2,3-BUTANEDIOL, MAGNESIUM ION, Probable ATP-dependent RNA helicase DDX58, ... | | 著者 | Wang, C, Marcotrigiano, J, Miller, M.T, Jiang, F. | | 登録日 | 2015-12-09 | | 公開日 | 2016-01-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | | 主引用文献 | Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Proc.Natl.Acad.Sci.USA, 113, 2016
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3O0M
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3NX0
 | | Hinge-loop mutation can be used to control 3D domain swapping and amyloidogenesis of human cystatin C | | 分子名称: | Cystatin-C, SULFATE ION | | 著者 | Orlikowska, M, Jankowska, E, Kolodziejczyk, R, Jaskolski, M, Szymanska, A. | | 登録日 | 2010-07-12 | | 公開日 | 2010-12-01 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Hinge-loop mutation can be used to control 3D domain swapping and amyloidogenesis of human cystatin C.
J.Struct.Biol., 173, 2011
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3NY3
 | | Structure of the ubr-box of UBR2 in complex with N-degron | | 分子名称: | E3 ubiquitin-protein ligase UBR2, N-degron, ZINC ION | | 著者 | Matta-Camacho, E, Kozlov, G, Li, F, Gehring, K. | | 登録日 | 2010-07-14 | | 公開日 | 2010-08-11 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural basis of substrate recognition and specificity in the N-end rule pathway.
Nat.Struct.Mol.Biol., 17, 2010
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3ETX
 | | Crystal structure of bacterial adhesin FadA L14A mutant | | 分子名称: | Adhesin A | | 著者 | Nithianantham, S, Xu, M, Wu, N, Shoham, M, Han, Y.W. | | 登録日 | 2008-10-08 | | 公開日 | 2008-12-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal Structure of FadA Adhesin from Fusobacterium nucleatum Reveals a Novel Oligomerization Motif, the Leucine Chain.
J.Biol.Chem., 284, 2009
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4XY9
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-amine-9H-purine ligand | | 分子名称: | 1,2-ETHANEDIOL, 6-(5-bromo-2-methoxyphenyl)-9H-purin-2-amine, Bromodomain-containing protein 4 | | 著者 | Picaud, S, von Delft, F, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Filippakopoulos, P, Structural Genomics Consortium (SGC) | | 登録日 | 2015-02-02 | | 公開日 | 2015-03-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | 9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain.
J.Med.Chem., 58, 2015
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2M8I
 | | Structure of Pin1 WW domain | | 分子名称: | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | | 著者 | Luh, L.M, Kirchner, D.K, Loehr, F, Haensel, R, Doetsch, V. | | 登録日 | 2013-05-22 | | 公開日 | 2014-04-09 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Molecular crowding drives active Pin1 into nonspecific complexes with endogenous proteins prior to substrate recognition.
J.Am.Chem.Soc., 135, 2013
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3O2M
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