3O2M

Crystal Structure of JNK1-alpha1 isoform complex with a biaryl tetrazol (A-82118)

Summary for 3O2M

• Entry DOI: 10.2210/pdb3o2m/pdb
• Related: 3O17
• Descriptor: Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, JIP1, 10MER PEPTIDE, N-butyl-4,6-dimethyl-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}pyrimidin-2-amine, ... (4 entities in total)
• Functional Keywords: serine threonine protein kinase, atp binding, phosphorylation, kinase-inhibitor complex, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm (By similarity): Q9WVI9
• Total number of polymer chains: 4
• Total formula weight: 89337.17

Authors

Abad-Zapatero, C. (deposition date: 2010-07-22, release date: 2011-01-12, Last modification date: 2024-02-21)

• Primary citation: Comess, K.M.,Sun, C.,Abad-Zapatero, C.,Goedken, E.R.,Gum, R.J.,Borhani, D.W.,Argiriadi, M.,Groebe, D.R.,Jia, Y.,Clampit, J.E.,Haasch, D.L.,Smith, H.T.,Wang, S.,Song, D.,Coen, M.L.,Cloutier, T.E.,Tang, H.,Cheng, X.,Quinn, C.,Liu, B.,Xin, Z.,Liu, G.,Fry, E.H.,Stoll, V.,Ng, T.I.,Banach, D.,Marcotte, D.,Burns, D.J.,Calderwood, D.J.,Hajduk, P.J.; Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.; Acs Chem.Biol., 6:234-244, 2011; PubMed: 21090814; DOI: 10.1021/cb1002619

Experimental method

X-RAY DIFFRACTION (2.7 Å)