PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

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6U8O	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction 分子名称: 5-bromo-N-[5-(1-cyanocyclobutyl)-2-hydroxyphenyl]-2-hydroxybenzene-1-sulfonamide, WD repeat-containing protein 5 著者 Zhao, B, Wang, F. 登録日 2019-09-05 公開日 2019-12-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
6UJ4	Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction 分子名称: 5-bromo-3-chloro-N-(1-cyclopentyl-2-methyl-1H-imidazol-4-yl)-2-hydroxybenzene-1-sulfonamide, WD repeat domain 5 著者 Zhao, B. 登録日 2019-10-02 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6UJL	Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction 分子名称: 6-methyl-3-(propylsulfanyl)-1,2,4-triazin-5-ol, WD repeat-containing protein 5 著者 Phan, J. 登録日 2019-10-03 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.599 Å) 主引用文献 Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6UJJ	Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction 分子名称: 5-[4-(trifluoromethyl)phenyl]-1H-tetrazole, WD repeat-containing protein 5 著者 Phan, J. 登録日 2019-10-03 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.731 Å) 主引用文献 Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6BEV	Human Single Domain Sulfurtranferase TSTD1 分子名称: Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 著者 Motl, N, Akey, D.L, Smith, J.L, Banerjee, R. 登録日 2017-10-25 公開日 2018-01-24 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.043 Å) 主引用文献 Thiosulfate sulfurtransferase-like domain-containing 1 protein interacts with thioredoxin. J. Biol. Chem., 293, 2018
6OSJ	Cryo-EM structure of the N-terminally acetylated full length alpha-synuclein fibrils (Ac1-140) 分子名称: Alpha-synuclein 著者 Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L. 登録日 2019-05-01 公開日 2019-09-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
8GI6	Crystal structure of RhoA mutant L69R complexed with GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA 著者 Chen, X, Qian, X, Chandravanshi, M, Lowy, D.R, Walters, K.J. 登録日 2023-03-13 公開日 2024-03-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Ras-like GTPases mutant structures To be published
8GI3	Crystal structure of RhoA mutant L69P complexed with GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA 著者 Chen, X, Qian, X, Chandravanshi, M, Lowy, D.R, Walters, K.J. 登録日 2023-03-13 公開日 2024-03-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Ras-like GTPases mutants structure To be published
6OSL	Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation Ac1-122 分子名称: Alpha-synuclein 著者 Ni, X, McGlinchey, R.P, Jiang, J, Lee, J.C. 登録日 2019-05-01 公開日 2019-09-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
8F1G	Crystal structure of human WDR5 in complex with compound WM662 分子名称: (2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid, GLYCEROL, SULFATE ION, ... 著者 Liu, H. 登録日 2022-11-05 公開日 2023-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. Acs Chem.Biol., 18, 2023
2GRO	Crystal Structure of human RanGAP1-Ubc9-N85Q 分子名称: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I 著者 Yunus, A.A, Lima, C.D. 登録日 2006-04-24 公開日 2006-05-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. Nat.Struct.Mol.Biol., 13, 2006
2GRN	Crystal Structure of human RanGAP1-Ubc9 分子名称: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I 著者 Yunus, A.A, Lima, C.D. 登録日 2006-04-24 公開日 2006-05-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. Nat.Struct.Mol.Biol., 13, 2006
7N1R	A novel and unique ATP hydrolysis to AMP by a human Hsp70 BiP 分子名称: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, Endoplasmic reticulum chaperone BiP, ... 著者 Yang, J, Musayev, F, Liu, Q. 登録日 2021-05-28 公開日 2022-01-12 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 A novel and unique ATP hydrolysis to AMP by a human Hsp70 Binding immunoglobin protein (BiP). Protein Sci., 31, 2022
4LL1	The structure of the TRX and TXNIP complex 分子名称: Thioredoxin, Thioredoxin-interacting protein 著者 Hwang, J, Kim, M.H. 登録日 2013-07-09 公開日 2014-02-05 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein Nat Commun, 5, 2014
6PES	Cryo-EM structure of alpha-synuclein H50Q Wide Fibril 分子名称: Alpha-synuclein 著者 Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. 登録日 2019-06-20 公開日 2019-11-27 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat.Struct.Mol.Biol., 26, 2019
2GRQ	Crystal Structure of human RanGAP1-Ubc9-D127A 分子名称: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I 著者 Yunus, A.A, Lima, C.D. 登録日 2006-04-24 公開日 2006-05-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. Nat.Struct.Mol.Biol., 13, 2006
4Q0X	Crystal structure of non-neutralizing antibody in complex with Epitope II of HCV E2 分子名称: Envelope glycoprotein E2, mAb 12 heavy chain, mAb 12 light chain 著者 Deng, L, Zhang, P. 登録日 2014-04-02 公開日 2014-07-09 最終更新日 2014-08-06 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Discrete conformations of epitope II on the hepatitis C virus E2 protein for antibody-mediated neutralization and nonneutralization. Proc.Natl.Acad.Sci.USA, 111, 2014
2GRR	Crystal Structure of human RanGAP1-Ubc9-D127S 分子名称: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I 著者 Yunus, A.A, Lima, C.D. 登録日 2006-04-24 公開日 2006-05-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. Nat.Struct.Mol.Biol., 13, 2006
2M4H	Solution structure of the Core Domain (10-76) of the Feline Calicivirus VPg protein 分子名称: Feline Calicivirus VPg protein 著者 Kwok, R.N, Leen, E.N, Birtley, J.R, Prater, S.N, Simpson, P.J, Curry, S, Matthews, S, Marchant, J. 登録日 2013-02-05 公開日 2013-03-27 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structures of the Compact Helical Core Domains of Feline Calicivirus and Murine Norovirus VPg Proteins. J.Virol., 87, 2013
1L8Y	Solution structure of HMG box 5 in human upstream binding factor 分子名称: upstream binding factor 1 著者 Yang, W, Xu, Y, Wu, J, Zeng, W, Shi, Y. 登録日 2002-03-22 公開日 2002-06-05 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor Biochemistry, 42, 2003
8F93	WDR5 covalently modified at Y228 by (R)-2-SF 分子名称: 3-ethynyl-5-{[(3R)-4-{1-[(2-methoxyphenyl)methyl]-1H-benzimidazole-5-carbonyl}-3-methylpiperazin-1-yl]methyl}benzene-1-sulfonyl fluoride, CHLORIDE ION, GLYCEROL, ... 著者 Taunton, J, Craven, G.B, Chen, Y. 登録日 2022-11-23 公開日 2023-05-31 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. Nat.Chem., 15, 2023
1L8Z	Solution structure of HMG box 5 in human upstream binding factor 分子名称: upstream binding factor 1 著者 Yang, W, Xu, Y, Wu, J, Zeng, W, Shi, Y. 登録日 2002-03-22 公開日 2002-06-05 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor Biochemistry, 42, 2003
6UOZ	Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction 分子名称: 5-bromo-3-chloro-N-[1-cyclopentyl-2-(methylsulfonyl)-1H-imidazol-4-yl]-2-hydroxybenzene-1-sulfonamide, WD repeat domain 5 著者 Zhao, B. 登録日 2019-10-16 公開日 2020-04-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.532 Å) 主引用文献 Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
5Y81	NuA4 TEEAA sub-complex 分子名称: Actin, Actin-related protein 4, Chromatin modification-related protein EAF1, ... 著者 Wang, X, Cai, G. 登録日 2017-08-18 公開日 2018-04-18 最終更新日 2019-11-06 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex Nat Commun, 9, 2018
5TUU	Crystal structure of the E2F4-DP1 coiled coil and marked-box domains 分子名称: GLYCEROL, Transcription factor DP1, Transcription factor E2F4 著者 Liban, T.J, Rubin, S.M, Tripathi, S.M. 登録日 2016-11-07 公開日 2017-05-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.251 Å) 主引用文献 Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

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