8OUR
| CRYSTAL STRUCTURE OF DLK IN COMPLEX WITH COMPOUND 16 | 分子名称: | 5-[1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)-2-propan-2-yl-imidazol-4-yl]-3-(trifluoromethyloxy)pyridin-2-amine, Mitogen-activated protein kinase kinase kinase 12 | 著者 | Zebisch, M, McEwan, P.A, Barker, J.J, Cross, J.B. | 登録日 | 2023-04-24 | 公開日 | 2023-07-26 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy. J.Med.Chem., 66, 2023
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8ZC4
| SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with 3 D1F6 Fabs (2 RBD up) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of D1F6 Fab, ... | 著者 | Liu, B, Gao, X, Li, Z, Chen, Q, He, J, Xiong, X. | 登録日 | 2024-04-28 | 公開日 | 2024-05-15 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.95 Å) | 主引用文献 | An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike. Cell Rep, 43, 2024
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8XFV
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8XGA
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9LYZ
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7SEU
| Crystal structure of E coli contaminant protein YncE co-purified with a plant protein | 分子名称: | PQQ-dependent catabolism-associated beta-propeller protein | 著者 | Chai, L, Zhu, P, Chai, J, Pang, C, Andi, B, McsWeeney, S, Shanklin, J, Liu, Q. | 登録日 | 2021-10-01 | 公開日 | 2022-04-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | AlphaFold Protein Structure Database for Sequence-Independent Molecular Replacement Crystals, 11, 2021
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8VZ1
| Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with k-409 | 分子名称: | 4,4'-[(1S,4S,5R)-5-(6-methoxy-3,4-dihydroquinoline-1(2H)-sulfonyl)-7-oxabicyclo[2.2.1]hept-2-ene-2,3-diyl]diphenol, Estrogen receptor | 著者 | Min, C.K, Nwachukwu, J.C, Hou, Y, Russo, R.J, Papa, A, Min, J, Peng, R, Kim, S.H, Ziegler, Y, Rangarajan, E.S, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W. | 登録日 | 2024-02-09 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu. Proc.Natl.Acad.Sci.USA, 121, 2024
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6OMR
| Crystal structure of PtmU3 complexed with PTN substrate | 分子名称: | ACETATE ION, MANGANESE (II) ION, PtmU3, ... | 著者 | Liu, Y.C, Dong, L.B, Shen, B. | 登録日 | 2019-04-19 | 公開日 | 2019-07-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis. J.Am.Chem.Soc., 141, 2019
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6O8C
| Crystal structure of STING CTT in complex with TBK1 | 分子名称: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | 著者 | Li, P, Zhao, B, Du, F. | 登録日 | 2019-03-09 | 公開日 | 2019-05-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.17 Å) | 主引用文献 | A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1. Nature, 569, 2019
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6UDK
| HIV-1 bNAb 1-55 in complex with modified BG505 SOSIP-based immunogen RC1 and 10-1074 | 分子名称: | 1-55 Fab Heavy Chain, 1-55 Fab Light Chain, 10-1074 Fab Heavy Chain, ... | 著者 | Abernathy, M.E, Barnes, C.O, Gristick, H.B, Bjorkman, P.J. | 登録日 | 2019-09-19 | 公開日 | 2020-01-29 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody. Cell, 180, 2020
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8P6Y
| Cryo-EM structure of CAK in complex with nucleotide analogue ATPgS | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J. | 登録日 | 2023-05-30 | 公開日 | 2023-08-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | 主引用文献 | High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15, 2024
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5HUQ
| A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase | 分子名称: | 3-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium, Lactate racemization operon protein LarA, NICKEL (II) ION, ... | 著者 | Desguin, B, Zhang, T, Soumillion, P, Hols, P, Hu, J, Hausinger, R.P. | 登録日 | 2016-01-27 | 公開日 | 2016-02-10 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | METALLOPROTEINS. A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase. Science, 349, 2015
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6UDJ
| HIV-1 bNAb 1-18 in complex with BG505 SOSIP.664 and 10-1074 | 分子名称: | 1-18 Fab Heavy Chain, 1-18 Fab Light Chain, 10-1074 Fab Heavy Chain, ... | 著者 | Abernathy, M.E, Barnes, C.O, Gristick, H.B, Bjorkman, P.J. | 登録日 | 2019-09-19 | 公開日 | 2020-01-29 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody. Cell, 180, 2020
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6ZZW
| Structure of the N terminal domain of Bc2L-C lectin (1-131) in complex with Globo H (H-type 3) and CAS No 912569-62-1 | 分子名称: | Lectin, SODIUM ION, [3-(2-methylimidazol-1-yl)phenyl]methanamine, ... | 著者 | Lal, K, Bermeo, R, Imberty, A, Varrot, A. | 登録日 | 2020-08-05 | 公開日 | 2021-04-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia cenocepacia*. Chemistry, 27, 2021
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7SCX
| KRAS full-length G12V in complex with RGL1 Ras association domain | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... | 著者 | Eves, B.J, Kuntz, D.A, Ikura, M, Marshall, C.B. | 登録日 | 2021-09-29 | 公開日 | 2022-05-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant. J.Mol.Biol., 434, 2022
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8P6V
| Cryo-EM structure of CAK in complex with inhibitor ICEC0942 | 分子名称: | (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ... | 著者 | Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J. | 登録日 | 2023-05-30 | 公開日 | 2023-08-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | 主引用文献 | High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15, 2024
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7S69
| N-acetylglucosamine-1-phosphotransferase (GNPT) gamma subunit (GNPTG), from clawed frog | 分子名称: | CHLORIDE ION, N-acetylglucosamine-1-phosphotransferase gamma subunit, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Gorelik, A, Illes, K, Nagar, B. | 登録日 | 2021-09-13 | 公開日 | 2022-05-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.04 Å) | 主引用文献 | Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase. Proc.Natl.Acad.Sci.USA, 119, 2022
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6ORH
| Crystal structure of SpGH29 | 分子名称: | 1,2-ETHANEDIOL, Glycoside hydrolase, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-alpha-D-glucopyranose | 著者 | Pluvinage, B, Boraston, A.B. | 登録日 | 2019-04-30 | 公開日 | 2019-07-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Two complementary alpha-fucosidases fromStreptococcus pneumoniaepromote complete degradation of host-derived carbohydrate antigens. J.Biol.Chem., 294, 2019
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5HAP
| OXA-48 beta-lactamase - S70A mutant | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, Beta-lactamase, ... | 著者 | Stojanoski, V, Adamski, C.J, Hu, L, Mehta, S.C, Sankaran, B, Prasad, B.V.V, Palzkill, T.G. | 登録日 | 2015-12-30 | 公開日 | 2016-09-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine beta-Lactamases by Relieving Steric Strain. Biochemistry, 55, 2016
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8OX0
| Structure of apo telomeric nucleosome | 分子名称: | Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, Histone H3.1, ... | 著者 | Hu, H, van Roon, A.M.M, Ghanim, G.E, Ahsan, B, Oluwole, A, Peak-Chew, S, Robinson, C.V, Nguyen, T.H.D. | 登録日 | 2023-04-28 | 公開日 | 2023-08-30 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | 主引用文献 | Structural basis of telomeric nucleosome recognition by shelterin factor TRF1. Sci Adv, 9, 2023
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8ORM
| Cryo-EM structure of CAK-THZ1 | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J. | 登録日 | 2023-04-14 | 公開日 | 2023-08-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | 主引用文献 | High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15, 2024
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5HZB
| Crystal structure of GII.10 P domain in complex with 2-fucosyllactose (2'FL) | 分子名称: | 1,2-ETHANEDIOL, Capsid protein, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Hansman, G.S, Koromyslova, A.D, Singh, B.K.S. | 登録日 | 2016-02-02 | 公開日 | 2016-03-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.553 Å) | 主引用文献 | Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides. J.Virol., 90, 2016
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8OX1
| Structure of TRF1core in complex with telomeric nucleosome | 分子名称: | Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, Histone H3.1, ... | 著者 | Hu, H, van Roon, A.M.M, Ghanim, G.E, Ahsan, B, Oluwole, A, Peak-Chew, S, Robinson, C.V, Nguyen, T.H.D. | 登録日 | 2023-04-28 | 公開日 | 2023-08-30 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural basis of telomeric nucleosome recognition by shelterin factor TRF1. Sci Adv, 9, 2023
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6XF9
| Crystal structure of KSHV ORF68 | 分子名称: | Packaging protein UL32, ZINC ION | 著者 | Didychuk, A.L, Gates, S.N, Martin, A, Glaunsinger, B. | 登録日 | 2020-06-15 | 公開日 | 2021-02-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | A pentameric protein ring with novel architecture is required for herpesviral packaging. Elife, 10, 2021
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4URF
| Molecular Genetic and Crystal Structural Analysis of 1-(4- Hydroxyphenyl)-Ethanol Dehydrogenase from Aromatoleum aromaticum EbN1 | 分子名称: | 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, ACETATE ION, BICARBONATE ION, ... | 著者 | Buesing, I, Hoeffken, H.W, Breuer, M, Woehlbrand, L, Hauer, B, Rabus, R. | 登録日 | 2014-06-28 | 公開日 | 2015-07-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Molecular Genetic and Crystal Structural Analysis of 1-(4-Hydroxyphenyl)-Ethanol Dehydrogenase from 'Aromatoleum Aromaticum' Ebn1. J.Mol.Microbiol.Biotechnol., 25, 2015
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