8XGA
Crystal structure of human Golgi resident glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-((tetrahydro-2H-pyran-4-yl)oxy)indolin-2-one
This is a non-PDB format compatible entry.
Summary for 8XGA
Entry DOI | 10.2210/pdb8xga/pdb |
Descriptor | Glutaminyl-peptide cyclotransferase-like protein, ZINC ION, (3~{Z})-3-(1~{H}-benzimidazol-5-ylmethylidene)-4-(oxan-4-yloxy)-1~{H}-indol-2-one, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 11 |
Total formula weight | 389578.09 |
Authors | Li, G.-B.,Wang, X.-Y. (deposition date: 2023-12-15, release date: 2024-06-12, Last modification date: 2024-06-26) |
Primary citation | Mou, J.,Ning, X.L.,Wang, X.Y.,Hou, S.Y.,Meng, F.B.,Zhou, C.,Wu, J.W.,Li, C.,Jia, T.,Wu, X.,Wu, Y.,Chen, Y.,Li, G.B. X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model. J.Med.Chem., 67:8730-8756, 2024 Cited by PubMed: 38817193DOI: 10.1021/acs.jmedchem.4c00049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.537 Å) |
Structure validation
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