6ZZW

Structure of the N terminal domain of Bc2L-C lectin (1-131) in complex with Globo H (H-type 3) and CAS No 912569-62-1

Summary for 6ZZW

• Entry DOI: 10.2210/pdb6zzw/pdb
• Descriptor: Lectin, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-alpha-D-galactopyranose, ... (6 entities in total)
• Functional Keywords: lectins, drug resistance, glycomimetics, anti-adhesive therapy, drug design, fragment based screening, sugar binding protein
• Biological source: Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)
• Total number of polymer chains: 3
• Total formula weight: 45016.69

Authors

Lal, K.,Bermeo, R.,Imberty, A.,Varrot, A. (deposition date: 2020-08-05, release date: 2021-04-07, Last modification date: 2024-01-31)

• Primary citation: Lal, K.,Bermeo, R.,Cramer, J.,Vasile, F.,Ernst, B.,Imberty, A.,Bernardi, A.,Varrot, A.,Belvisi, L.; Prediction and Validation of a Druggable Site on Virulence Factor of Drug Resistant Burkholderia cenocepacia*.; Chemistry, 27:10341-10348, 2021; PubMed: 33769626; DOI: 10.1002/chem.202100252

Experimental method

X-RAY DIFFRACTION (1.9 Å)