PDB: 2013 件ウェブページステータス検索Chemie searchBIRD

---

5V5G	OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.4 分子名称: 1,2-ETHANEDIOL, RNA-directed RNA polymerase L, SODIUM ION, ... 著者 Khare, B, Mark, B.L. 登録日 2017-03-14 公開日 2017-05-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants. PLoS Pathog., 13, 2017
5V0U	Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4723 4-(5-chlorothiophen-2-yl)-1H-pyrazole 分子名称: 4-(5-chlorothiophen-2-yl)-1H-pyrazole, Polymerase acidic protein 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2017-02-28 公開日 2017-03-08 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase To Be Published
5PZM	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 3-[2-(4-FLUOROPHENYL)-3-(METHYLCARBAMOYL)-1-BENZOFURAN-5-YL]BENZOIC ACID 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 3-[2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-5-yl]benzoic acid, GLYCEROL, ... 著者 Sheriff, S. 登録日 2017-02-27 公開日 2017-05-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem., 60, 2017
5PZO	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE C316N IN COMPLEX WITH 2-(4-FLUOROPHENYL)-N-METHYL-5-[3-({2-METHYL-1-OXO-1-[(1,3,4-THIADIAZOL-2-YL)AMINO]PROPAN-2-YL}CARBAMOYL)PHENYL]-1-BENZOFURAN-3-CARBOXAMIDE 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 2-(4-fluorophenyl)-N-methyl-5-[3-({2-methyl-1-oxo-1-[(1,3,4-thiadiazol-2-yl)amino]propan-2-yl}carbamoyl)phenyl]-1-benzofuran-3-carboxamide, GLYCEROL, ... 著者 Sheriff, S. 登録日 2017-02-27 公開日 2017-05-10 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem., 60, 2017
5PZN	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 5-[3-(TERT-BUTYLCARBAMOYL)PHENYL]-2-(4-FLUOROPHENYL)-N-METHYL-1-BENZOFURAN-3-CARBOXAMIDE 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 5-[3-(tert-butylcarbamoyl)phenyl]-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide, GLYCEROL, ... 著者 Sheriff, S. 登録日 2017-02-27 公開日 2017-05-10 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem., 60, 2017
5PZL	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 2-({3-[1-(2-CYCLOPROPYLETHYL)-6-FLUORO-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL]-1,1-DIOXO-1,4-DIHYDRO-1LAMBDA~6~,2,4-BENZOTHIADIAZIN-7-YL}OXY)ACETAMIDE 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 2-({3-[1-(2-cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl]-1,1-dioxo-1,4-dihydro-1lambda~6~,2,4-benzothiadiazin-7-yl}oxy)acetamide, RNA-directed RNA polymerase, ... 著者 Sheriff, S. 登録日 2017-02-27 公開日 2017-05-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem., 60, 2017
5PZK	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 2-(4-FLUOROPHENYL)-N-METHYL-6-[(METHYLSULFONYL)AMINO]-5-(PROPAN-2-YLOXY)-1-BENZOFURAN-3-CARBOXAMIDE 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide, GLYCEROL, ... 著者 Sheriff, S. 登録日 2017-02-27 公開日 2017-05-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem., 60, 2017
5PZP	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 4-FLUORO-2-(4-FLUOROPHENYL)-N-METHYL-5-(2-METHYL-5-{[1-(PYRIMIDIN-2-YL)CYCLOPROPYL]CARBAMOYL}PHENYL)-1-BENZOFURAN-3-CARBOXAMIDE (BMS-929075) 分子名称: (2E)-3-(4-{[(1-{[(13-cyclohexyl-6-oxo-6,7-dihydro-5H-indolo[1,2-d][1,4]benzodiazepin-10-yl)carbonyl]amino}cyclopentyl)carbonyl]amino}phenyl)prop-2-enoic acid, 4-fluoro-2-(4-fluorophenyl)-N-methyl-5-(2-methyl-5-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide, GLYCEROL, ... 著者 Sheriff, S. 登録日 2017-02-27 公開日 2017-05-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J. Med. Chem., 60, 2017
5N8X	Trigonal structure of mutant V173I of 3D polymerase from Foot-and-Mouth Disease Virus 分子名称: 3D polymerase, GLYCEROL, MANGANESE (II) ION 著者 Ferrer-Orta, C, Verdaguer, N. 登録日 2017-02-24 公開日 2017-05-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus. Genome Biol Evol, 9, 2017
5N95	Tetragonal structure of mutant V173I of 3D polymerase from Foot-and-Mouth Disease Virus 分子名称: 3D polymerase, TRIPHOSPHATE 著者 Ferrer-Orta, C, Verdaguer, N. 登録日 2017-02-24 公開日 2017-05-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus. Genome Biol Evol, 9, 2017
5X50	RNA Polymerase II from Komagataella Pastoris (Type-2 crystal) 分子名称: DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, RNA polymerase II subunit, ... 著者 Ehara, H, Umehara, T, Sekine, S, Yokoyama, S. 登録日 2017-02-14 公開日 2017-05-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (4.293 Å) 主引用文献 Crystal structure of RNA polymerase II from Komagataella pastoris Biochem. Biophys. Res. Commun., 487, 2017
5X51	RNA Polymerase II from Komagataella Pastoris (Type-3 crystal) 分子名称: DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, RNA polymerase II subunit, ... 著者 Ehara, H, Umehara, T, Sekine, S, Yokoyama, S. 登録日 2017-02-14 公開日 2017-05-17 実験手法 X-RAY DIFFRACTION (6.996 Å) 主引用文献 Crystal structure of RNA polymerase II from Komagataella pastoris Biochem. Biophys. Res. Commun., 487, 2017
5X4Z	RNA Polymerase II from Komagataella Pastoris (Type-1 crystal) 分子名称: DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit beta, RNA polymerase II subunit, ... 著者 Ehara, H, Umehara, T, Sekine, S, Yokoyama, S. 登録日 2017-02-14 公開日 2017-05-17 実験手法 X-RAY DIFFRACTION (7.8 Å) 主引用文献 Crystal structure of RNA polymerase II from Komagataella pastoris Biochem. Biophys. Res. Commun., 487, 2017
5N61	RNA polymerase I initially transcribing complex 分子名称: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... 著者 Engel, C, Gubbey, T, Neyer, S, Sainsbury, S, Oberthuer, C, Baejen, C, Bernecky, C, Cramer, P. 登録日 2017-02-14 公開日 2017-04-05 最終更新日 2019-10-02 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural Basis of RNA Polymerase I Transcription Initiation. Cell, 169, 2017
5N5Y	Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation III) 分子名称: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... 著者 Engel, C, Gubbey, T, Neyer, S, Sainsbury, S, Oberthuer, C, Baejen, C, Bernecky, C, Cramer, P. 登録日 2017-02-14 公開日 2017-04-05 最終更新日 2018-10-03 実験手法 ELECTRON MICROSCOPY (7.7 Å) 主引用文献 Structural Basis of RNA Polymerase I Transcription Initiation. Cell, 169, 2017
5N5Z	Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation II) 分子名称: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... 著者 Engel, C, Gubbey, T, Neyer, S, Sainsbury, S, Oberthuer, C, Baejen, C, Bernecky, C, Cramer, P. 登録日 2017-02-14 公開日 2017-04-05 最終更新日 2018-10-03 実験手法 ELECTRON MICROSCOPY (7.7 Å) 主引用文献 Structural Basis of RNA Polymerase I Transcription Initiation. Cell, 169, 2017
5N60	Cryo-EM structure of RNA polymerase I in complex with Rrn3 and Core Factor (Orientation I) 分子名称: DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... 著者 Engel, C, Gubbey, T, Neyer, S, Sainsbury, S, Oberthuer, C, Baejen, C, Bernecky, C, Cramer, P. 登録日 2017-02-14 公開日 2017-04-05 最終更新日 2018-10-03 実験手法 ELECTRON MICROSCOPY (7.7 Å) 主引用文献 Structural Basis of RNA Polymerase I Transcription Initiation. Cell, 169, 2017
5WZ2	Crystal structure of Zika virus NS5 methyltransferase bound to SAM and RNA analogue (m7GpppA) 分子名称: NS5 MTase, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, S-ADENOSYLMETHIONINE 著者 Duan, W, Song, H, Qi, J, Shi, Y, Gao, G.F. 登録日 2017-01-16 公開日 2017-03-08 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The crystal structure of Zika virus NS5 reveals conserved drug targets. EMBO J., 36, 2017
5WZ3	Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase(RdRP) 分子名称: NS5 RdRp, ZINC ION 著者 Duan, W, Song, H, Qi, J, Shi, Y, Gao, G.F. 登録日 2017-01-16 公開日 2017-03-08 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.804 Å) 主引用文献 The crystal structure of Zika virus NS5 reveals conserved drug targets. EMBO J., 36, 2017
5UJ2	Crystal structure of HCV NS5B genotype 2A JFH-1 isolate with S15G E86Q E87Q C223H V321I mutations and Delta8 neta hairpoin loop deletion in complex with GS-639476 (diphsohate version of GS-9813), Mn2+ and symmetrical primer template 5'-AUAAAUUU 分子名称: (1S)-1-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-1,4-anhydro-2-deoxy-2-fluoro-5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-2-methyl-D-ribitol, CHLORIDE ION, Genome polyprotein, ... 著者 Edwards, T.E, Fox III, D, Appleby, T.C, Murakami, E, Rey, A, McGrath, M.E. 登録日 2017-01-16 公開日 2017-03-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties. Bioorg. Med. Chem. Lett., 27, 2017
5WZ1	Crystal structure of Zika virus NS5 methyltransferase bound to S-adenosyl-L-methionine 分子名称: NS5 methyltransferase, S-ADENOSYLMETHIONINE 著者 Duan, W, Song, H, Qi, J, Shi, Y, Gao, G.F. 登録日 2017-01-16 公開日 2017-03-08 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.507 Å) 主引用文献 The crystal structure of Zika virus NS5 reveals conserved drug targets. EMBO J., 36, 2017
5MSG	Influenza B polymerase bound to vRNA promoter and capped RNA primer 分子名称: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ... 著者 Cusack, S, Guilligay, D. 登録日 2017-01-04 公開日 2017-02-08 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 An in vitro fluorescence based study of initiation of RNA synthesis by influenza B polymerase. Nucleic Acids Res., 45, 2017
5U5Q	12 Subunit RNA Polymerase II at Room Temperature collected using SFX 分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... 著者 Bushnell, D.A, Oberthur, D, Mariani, V, Yefanov, O, Tolstikova, A, Barty, A. 登録日 2016-12-07 公開日 2017-03-29 最終更新日 2019-11-27 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Double-flow focused liquid injector for efficient serial femtosecond crystallography. Sci Rep, 7, 2017
5MJV	Rebuild and re-refined model for Human Parechovirus 1 分子名称: CAPSID SUBUNIT VP0, CAPSID SUBUNIT VP1, CAPSID SUBUNIT VP3, ... 著者 Shakeel, S, Dykeman, E.C, White, S.J, Ora, A, Cockburn, J.J.B, Butcher, S.J, Stockley, P.G, Twarock, R. 登録日 2016-12-01 公開日 2017-01-11 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Genomic RNA folding mediates assembly of human parechovirus. Nat Commun, 8, 2017
5MI3	Structure of phosphorylated translation elongation factor EF-Tu from E. coli 分子名称: Elongation factor Tu 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Talavera, A, Hendrix, J, Versees, W, De Gieter, S, Castro-Roa, D, Jurenas, D, Van Nerom, K, Vandenberk, N, Barth, A, De Greve, H, Hofkens, J, Zenkin, N, Loris, R, Garcia-Pino, A. 登録日 2016-11-27 公開日 2017-12-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors. Sci Adv, 4, 2018

<31323334353637383940414243444546>