5V0U

Crystal structure of polymerase acid protein (PA) from Influenza A virus, WILSON-SMITH/1933 (H1N1) bound to follow on fragment EBSI-4723 4-(5-chlorothiophen-2-yl)-1H-pyrazole

Summary for 5V0U

• Entry DOI: 10.2210/pdb5v0u/pdb
• Related: 4iuj 5IEQ 5IF2 5IF5 5IF7 5IF8 5IFB 5IFC 5IFD
• Descriptor: Polymerase acidic protein, 4-(5-chlorothiophen-2-yl)-1H-pyrazole (3 entities in total)
• Functional Keywords: fragment screening, flu, ppi, protein-protein interface, fbld, fragment-based ligand discovery, structural genomics, seattle structural genomics center for infectious disease, ssgcid, transcription
• Biological source: Influenza A virus (strain A/Wilson-Smith/1933 H1N1)
• Cellular location: Host cytoplasm: P15659
• Total number of polymer chains: 1
• Total formula weight: 53281.37

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2017-02-28, release date: 2017-03-08, Last modification date: 2023-10-04)

• Primary citation: Pierce, P.G.,Muruthii, M.M.,Moen, S.O.,Abendroth, J.,Davies, D.R.,Labaied, M.,Marathias, V.M.,Begley, D.W.,Hokanson, D.,Suto, R.K.,Hubbard, B.K.,Myler, P.J.,Lorimer, D.D.,Edwards, T.E.; Fragment screening by STD NMR identifies novel site binders against influenza A virus polymerase; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)