5WZ2

Crystal structure of Zika virus NS5 methyltransferase bound to SAM and RNA analogue (m7GpppA)

Summary for 5WZ2

• Entry DOI: 10.2210/pdb5wz2/pdb
• Related: 5WZ1 5WZ3
• Descriptor: NS5 MTase, S-ADENOSYLMETHIONINE, P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: zika virus, methytransferase, rna analogue, sam, transferase
• Biological source: Zika virus (strain Mr 766) (ZIKV)
• Cellular location: Virion membrane ; Multi-pass membrane protein : A0A140E7U5
• Total number of polymer chains: 3
• Total formula weight: 95630.65

Authors

Duan, W.,Song, H.,Qi, J.,Shi, Y.,Gao, G.F. (deposition date: 2017-01-16, release date: 2017-03-08, Last modification date: 2023-11-22)

• Primary citation: Duan, W.,Song, H.,Wang, H.,Chai, Y.,Su, C.,Qi, J.,Shi, Y.,Gao, G.F.; The crystal structure of Zika virus NS5 reveals conserved drug targets.; EMBO J., 36:919-933, 2017; PubMed: 28254839; DOI: 10.15252/embj.201696241

Experimental method

X-RAY DIFFRACTION (2.6 Å)