PDB: 2705 件ウェブページステータス検索Chemie searchBIRD

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4BSK	Crystal structure of VEGF-C in complex with VEGFR-3 domains D1-2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, VASCULAR ENDOTHELIAL GROWTH FACTOR C, ... 著者 Leppanen, V.M, Tvorogov, D, Kisko, K, Prota, A.E, Jeltsch, M, Anisimov, A, Markovic-Mueller, S, Stuttfeld, E, Goldie, K.N, Ballmer-Hofer, K, Alitalo, K. 登録日 2013-06-10 公開日 2013-07-31 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (4.201 Å) 主引用文献 Structural and Mechanistic Insights Into Vegfr-3 Ligand Binding and Activation Proc.Natl.Acad.Sci.USA, 110, 2013
4CG6	Cryo-em of the Sec61-complex bound to the 80s ribosome translating a membrane-inserting substrate 分子名称: PEPTIDE, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT BETA, ... 著者 Gogala, M, Becker, T, Beatrix, B, Barrio-Garcia, C, Berninghausen, O, Beckmann, R. 登録日 2013-11-21 公開日 2014-02-05 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (7.8 Å) 主引用文献 Structures of the Sec61 Complex Engaged in Nascent Peptide Translocation or Membrane Insertion. Nature, 506, 2014
4CG7	Cryo-EM of the Sec61-complex bound to the idle 80S ribosome 分子名称: PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT GAMMA, TRANSPORT PROTEIN SEC61 SUBUNIT BETA 著者 Gogala, M, Becker, T, Beatrix, B, Barrio-Garcia, C, Berninghausen, O, Beckmann, R. 登録日 2013-11-21 公開日 2014-02-05 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (6.9 Å) 主引用文献 Structures of the Sec61 Complex Engaged in Nascent Peptide Translocation or Membrane Insertion. Nature, 506, 2014
4B0M	Complex of the Caf1AN usher domain, Caf1M chaperone and Caf1 subunit from Yersinia pestis 分子名称: CHAPERONE PROTEIN CAF1M, F1 CAPSULE ANTIGEN, F1 CAPSULE-ANCHORING PROTEIN 著者 Dubnovitsky, A, Yu, X.D, Pudney, A.F, MacIntyre, S, Knight, S.D, Zavialov, A.V. 登録日 2012-07-03 公開日 2012-09-26 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Allosteric Mechanism Controls Traffic in the Chaperone/Usher Pathway. Structure, 20, 2012
4CG5	Cryo-EM of the Sec61-complex bound to the 80S ribosome translating a secretory substrate 分子名称: PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT BETA, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT GAMMA 著者 Gogala, M, Becker, T, Beatrix, B, Barrio-Garcia, C, Berninghausen, O, Beckmann, R. 登録日 2013-11-21 公開日 2014-02-05 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (7.4 Å) 主引用文献 Structures of the Sec61 Complex Engaged in Nascent Peptide Translocation or Membrane Insertion. Nature, 506, 2014
1FLT	VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR 分子名称: FMS-LIKE TYROSINE KINASE 1, VASCULAR ENDOTHELIAL GROWTH FACTOR 著者 Wiesmann, C, De Vos, A.M. 登録日 1997-11-20 公開日 1999-01-13 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor. Cell(Cambridge,Mass.), 91, 1997
1P5U	X-ray structure of the ternary Caf1M:Caf1:Caf1 chaperone:subunit:subunit complex 分子名称: Chaperone protein Caf1M, F1 capsule antigen 著者 Zavialov, A.V, Berglund, J, Pudney, A.F, Fooks, L.J, Ibrahim, T.M, MacIntyre, S, Knight, S.D. 登録日 2003-04-28 公開日 2003-06-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Structure and Biogenesis of the Capsular F1 Antigen from Yersinia pestis. Preserved Folding Energy Drives Fiber Formation Cell(Cambridge,Mass.), 113, 2003
1PDK	PAPD-PAPK CHAPERONE-PILUS SUBUNIT COMPLEX FROM E.COLI P PILUS 分子名称: PROTEIN (CHAPERONE PROTEIN PAPD), PROTEIN (PROTEIN PAPK) 著者 Fuetterer, K, Sauer, F.G, Hultgren, S.J, Waksman, G. 登録日 1999-03-29 公開日 1999-08-17 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis of chaperone function and pilus biogenesis. Science, 285, 1999
1P5V	X-ray structure of the Caf1M:Caf1 chaperone:subunit preassembly complex 分子名称: Chaperone protein Caf1M, F1 capsule antigen 著者 Zavialov, A.V, Berglund, J, Pudney, A.F, Fooks, L.J, Ibrahim, T.M, MacIntyre, S, Knight, S.D. 登録日 2003-04-28 公開日 2003-06-24 最終更新日 2018-03-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure and Biogenesis of the Capsular F1 Antigen from Yersinia pestis. Preserved Folding Energy Drives Fiber Formation Cell(Cambridge,Mass.), 113, 2003
4DEP	Structure of the IL-1b signaling complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 beta, Interleukin-1 receptor accessory protein, ... 著者 Thomas, C, Garcia, K.C. 登録日 2012-01-21 公開日 2012-03-21 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure of the activating IL-1 receptor signaling complex. Nat.Struct.Mol.Biol., 19, 2012
1QTY	VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR 分子名称: FMS-LIKE TYROSINE KINASE 1, VASCULAR ENDOTHELIAL GROWTH FACTOR 著者 Wiesmann, C, de Vos, A.M. 登録日 1999-06-29 公開日 2000-01-12 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states. J.Mol.Biol., 293, 1999
1QUN	X-RAY STRUCTURE OF THE FIMC-FIMH CHAPERONE ADHESIN COMPLEX FROM UROPATHOGENIC E.COLI 分子名称: MANNOSE-SPECIFIC ADHESIN FIMH, PAPD-LIKE CHAPERONE FIMC 著者 Choudhury, D, Thompson, A, Stojanoff, V, Langerman, S, Pinkner, J, Hultgren, S.J, Knight, S. 登録日 1999-07-01 公開日 1999-08-31 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli. Science, 285, 1999
4EKX	Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18 分子名称: 14L protein, Interleukin-18 著者 Krumm, B.E, Xiang, Y, Deng, J. 登録日 2012-04-10 公開日 2012-09-26 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 A unique bivalent binding and inhibition mechanism by the yatapoxvirus interleukin 18 binding protein. Plos Pathog., 8, 2012
4IXC	Crystal structure of Human Glucokinase in complex with a small molecule activator. 分子名称: (2S)-2-{[1-(3-chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(5-methylpyridin-2-yl)-3-(propan-2-yloxy)propanamide, Glucokinase isoform 3, SODIUM ION, ... 著者 Ogg, D.J, Hargreaves, D, Gerhardt, S. 登録日 2013-01-25 公開日 2013-04-24 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Matched triplicate design sets in the optimisation of glucokinase activators maximising medicinal chemistry information content To be Published
4ISE	Human glucokinase in complex with novel activator (2S)-3-cyclohexyl-2-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-N-(1,3-thiazol-2-yl)propanamide 分子名称: (2S)-3-cyclohexyl-2-(6-fluoro-4-oxoquinazolin-3(4H)-yl)-N-(1,3-thiazol-2-yl)propanamide, Glucokinase, IODIDE ION, ... 著者 Hosfield, D, Skene, R.J. 登録日 2013-01-16 公開日 2013-03-20 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Design, synthesis and SAR of novel glucokinase activators. Bioorg.Med.Chem.Lett., 23, 2013
4GAF	Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra, bound to human Interleukin-1 receptor type 1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, EBI-005, Interleukin-1 receptor type 1, ... 著者 Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. 登録日 2012-07-25 公開日 2013-02-20 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Design of a superior cytokine antagonist for topical ophthalmic use. Proc.Natl.Acad.Sci.USA, 110, 2013
5H9D	Crystal structure of Heptaprenyl Diphosphate Synthase from Staphylococcus aureus 分子名称: C-terminal peptide from Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 family protein, Farnesyl pyrophosphate synthetase, Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 family protein, ... 著者 Wei, H.L, Liu, W.D, Zheng, Y.Y, Ko, T.P, Chen, C.C, Guo, R.T. 登録日 2015-12-28 公開日 2016-12-28 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase ChemMedChem, 11, 2016
5HEX	Crystal Structure of Human Hexokinase 2 with cmpd 30, a 2-amino-6-benzenesulfonamide glucosamine 分子名称: 2-[(3-bromobenzene-1-carbonyl)amino]-6-{[(4-carboxy-5-methylfuran-2-yl)sulfonyl]amino}-2,6-dideoxy-alpha-D-glucopyranos e, Hexokinase-2 著者 Campobasso, N, Zhao, B, Smallwood, A. 登録日 2016-01-06 公開日 2016-03-30 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.734 Å) 主引用文献 Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors. Acs Med.Chem.Lett., 7, 2016
5HG1	Crystal Structure of Human Hexokinase 2 with cmpd 1, a C-2-substituted glucosamine 分子名称: 2-deoxy-2-{[(2E)-3-(3,4-dichlorophenyl)prop-2-enoyl]amino}-alpha-D-glucopyranose, 6-O-phosphono-beta-D-glucopyranose, CITRATE ANION, ... 著者 Campobasso, N, Zhao, B, Smallwood, A. 登録日 2016-01-07 公開日 2016-03-30 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors. Acs Med.Chem.Lett., 7, 2016
5HFU	Crystal Structure of Human Hexokinase 2 with cmpd 27, a 2-amido-6-benzenesulfonamide glucosamine 分子名称: Hexokinase-2, ~{N}-[(2~{S},3~{R},4~{R},5~{S},6~{R})-6-[[(4-cyanophenyl)sulfonylamino]methyl]-2,4,5-tris(oxidanyl)oxan-3-yl]-3-phenyl-benzamide 著者 Campobasso, N, Zhao, B, Smallwood, A. 登録日 2016-01-07 公開日 2016-03-30 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.923 Å) 主引用文献 Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors. Acs Med.Chem.Lett., 7, 2016
4DWH	Structure of the major type 1 pilus subunit FIMA bound to the FIMC (2.5 A resolution) 分子名称: Chaperone protein fimC, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, ... 著者 Scharer, M.A, Puorger, C, Crespo, M, Glockshuber, R, Capitani, G. 登録日 2012-02-24 公開日 2012-05-30 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Quality control of disulfide bond formation in pilus subunits by the chaperone FimC. Nat.Chem.Biol., 8, 2012
2UY7	Crystal structure of the P pilus rod subunit PapA 分子名称: PAP FIMBRIAL MAJOR PILIN PROTEIN, PERIPLASMID CHAPERONE PAPD PROTEIN, SULFATE ION 著者 Verger, D, Bullitt, E, Hultgren, S.J, Waksman, G. 登録日 2007-04-02 公開日 2007-05-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structure of the P Pilus Rod Subunit Papa. Plos Pathog., 3, 2007
4F9O	Crystal Structure of recombinant human Hexokinase type I with 2-deoxy-Glucose 6-Phosphate 分子名称: 2-deoxy-6-O-phosphono-beta-D-glucopyranose, CITRIC ACID, Hexokinase-1, ... 著者 Shen, L, Honzatko, R.B. 登録日 2012-05-19 公開日 2013-06-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Inhibitor Sites of Unequal Affinity Linked by Binding Synergism in Mutant Forms of Recombinant Human Hexokinase Type-I to be published
4JAX	Crystal structure of dimeric KlHxk1 in crystal form X 分子名称: GLYCEROL, Hexokinase, PHOSPHATE ION 著者 Kuettner, E.B, Strater, N, Kettner, K, Otto, A, Lilie, H, Golbik, R.P, Kriegel, T.M. 登録日 2013-02-19 公開日 2013-05-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 In vivo phosphorylation and in vitro autophosphorylation-inactivation of Kluyveromyces lactis hexokinase KlHxk1. Biochem.Biophys.Res.Commun., 435, 2013
4FOE	Crystal Structure of recombinant human Hexokinase type I with Mannose 6-Phosphate 分子名称: 6-O-phosphono-beta-D-mannopyranose, CITRIC ACID, Hexokinase-1, ... 著者 Shen, L, Honzatko, R.B. 登録日 2012-06-20 公開日 2013-07-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Inhibitor Sites of Unequal Affinity Linked by Binding Synergism in Mutant Forms of Recombinant Human Hexokinase Type-I to be published

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