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5HFU

Crystal Structure of Human Hexokinase 2 with cmpd 27, a 2-amido-6-benzenesulfonamide glucosamine

Summary for 5HFU
Entry DOI10.2210/pdb5hfu/pdb
Related5HEX
DescriptorHexokinase-2, ~{N}-[(2~{S},3~{R},4~{R},5~{S},6~{R})-6-[[(4-cyanophenyl)sulfonylamino]methyl]-2,4,5-tris(oxidanyl)oxan-3-yl]-3-phenyl-benzamide (3 entities in total)
Functional Keywordsmetabolism, inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationMitochondrion outer membrane : P52789
Total number of polymer chains2
Total formula weight208299.25
Authors
Campobasso, N.,Zhao, B.,Smallwood, A. (deposition date: 2016-01-07, release date: 2016-03-30, Last modification date: 2024-03-06)
Primary citationLin, H.,Zeng, J.,Xie, R.,Schulz, M.J.,Tedesco, R.,Qu, J.,Erhard, K.F.,Mack, J.F.,Raha, K.,Rendina, A.R.,Szewczuk, L.M.,Kratz, P.M.,Jurewicz, A.J.,Cecconie, T.,Martens, S.,McDevitt, P.J.,Martin, J.D.,Chen, S.B.,Jiang, Y.,Nickels, L.,Schwartz, B.J.,Smallwood, A.,Zhao, B.,Campobasso, N.,Qian, Y.,Briand, J.,Rominger, C.M.,Oleykowski, C.,Hardwicke, M.A.,Luengo, J.I.
Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors.
Acs Med.Chem.Lett., 7:217-222, 2016
Cited by
PubMed: 26985301
DOI: 10.1021/acsmedchemlett.5b00214
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.923 Å)
Structure validation

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