5HFU

Crystal Structure of Human Hexokinase 2 with cmpd 27, a 2-amido-6-benzenesulfonamide glucosamine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Hexokinase-2	polymer	923	103102.5	2	UniProt (P52789) Pfam (PF00349) Pfam (PF03727) In PDB	Homo sapiens (Human)	Hexokinase type II,HK II,Muscle form hexokinase
2	A, B	~{N}-[(2~{S},3~{R},4~{R},5~{S},6~{R})-6-[[(4-cyanophenyl)sulfonylamino]methyl]-2,4,5-tris(oxidanyl)oxan-3-yl]-3-phenyl-benzamide	non-polymer		523.6	4	Chemie (603)
3		water	water		18.0	57	Chemie (HOH)

Sequence modifications

A, B: 17 - 917 (UniProt: P52789)

PDB	External Database	Details
Met -5	-	initiating methionine
Gly -4	-	expression tag
Ser -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
Ser 5	-	expression tag
Ser 6	-	expression tag
Gly 7	-	expression tag
Leu 8	-	expression tag
Glu 9	-	expression tag
Asn 10	-	expression tag
Leu 11	-	expression tag
Tyr 12	-	expression tag
Phe 13	-	expression tag
Gln 14	-	expression tag
Gly 15	-	expression tag
Ser 16	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	206205.0
Non-Polymers*	Number of molecules	4
	Total formula weight	2094.2
All*	Total formula weight	208299.2

*Water molecules are not included.