5HFU
Crystal Structure of Human Hexokinase 2 with cmpd 27, a 2-amido-6-benzenesulfonamide glucosamine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001678 | biological_process | intracellular glucose homeostasis |
| A | 0004340 | molecular_function | glucokinase activity |
| A | 0004396 | molecular_function | hexokinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005536 | molecular_function | D-glucose binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006002 | biological_process | fructose 6-phosphate metabolic process |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0008637 | biological_process | apoptotic mitochondrial changes |
| A | 0008865 | molecular_function | fructokinase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019318 | biological_process | hexose metabolic process |
| A | 0019637 | biological_process | organophosphate metabolic process |
| A | 0045766 | biological_process | positive regulation of angiogenesis |
| A | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| A | 0061621 | biological_process | canonical glycolysis |
| A | 0070585 | biological_process | protein localization to mitochondrion |
| A | 0072656 | biological_process | maintenance of protein location in mitochondrion |
| A | 1901135 | biological_process | carbohydrate derivative metabolic process |
| A | 1905091 | biological_process | positive regulation of type 2 mitophagy |
| B | 0001678 | biological_process | intracellular glucose homeostasis |
| B | 0004340 | molecular_function | glucokinase activity |
| B | 0004396 | molecular_function | hexokinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005536 | molecular_function | D-glucose binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005741 | cellular_component | mitochondrial outer membrane |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006002 | biological_process | fructose 6-phosphate metabolic process |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0008637 | biological_process | apoptotic mitochondrial changes |
| B | 0008865 | molecular_function | fructokinase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0019318 | biological_process | hexose metabolic process |
| B | 0019637 | biological_process | organophosphate metabolic process |
| B | 0045766 | biological_process | positive regulation of angiogenesis |
| B | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| B | 0061621 | biological_process | canonical glycolysis |
| B | 0070585 | biological_process | protein localization to mitochondrion |
| B | 0072656 | biological_process | maintenance of protein location in mitochondrion |
| B | 1901135 | biological_process | carbohydrate derivative metabolic process |
| B | 1905091 | biological_process | positive regulation of type 2 mitophagy |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue 603 A 1001 |
| Chain | Residue |
| A | LYS62 |
| A | ASN235 |
| A | GLU260 |
| A | GLN291 |
| A | GLU294 |
| A | SER155 |
| A | PRO157 |
| A | CYS158 |
| A | ASN208 |
| A | ASP209 |
| A | THR232 |
| A | GLY233 |
| A | SER234 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue 603 A 1002 |
| Chain | Residue |
| A | LYS510 |
| A | LYS621 |
| A | ASN656 |
| A | ASP657 |
| A | THR658 |
| A | ILE677 |
| A | THR680 |
| A | GLY681 |
| A | SER682 |
| A | ASN683 |
| A | GLU708 |
| A | GLN739 |
| A | GLU742 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue 603 B 1001 |
| Chain | Residue |
| B | LYS62 |
| B | LEU64 |
| B | SER155 |
| B | PRO157 |
| B | CYS158 |
| B | THR172 |
| B | ASN208 |
| B | ASP209 |
| B | ILE229 |
| B | THR232 |
| B | GLY233 |
| B | SER234 |
| B | ASN235 |
| B | GLU260 |
| B | GLU294 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue 603 B 1002 |
| Chain | Residue |
| B | LEU512 |
| B | SER603 |
| B | LYS621 |
| B | ASN656 |
| B | ASP657 |
| B | THR658 |
| B | THR680 |
| B | GLY681 |
| B | SER682 |
| B | ASN683 |
| B | GLU708 |
| B | GLU742 |
| B | HOH1119 |
Functional Information from PROSITE/UniProt
| site_id | PS00378 |
| Number of Residues | 26 |
| Details | HEXOKINASE_1 Hexokinase domain signature. LGFTFSFPchqtkLDesfLvsWTKgF |
| Chain | Residue | Details |
| A | LEU150-PHE175 | |
| A | LEU598-PHE623 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 884 |
| Details | Domain: {"description":"Hexokinase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 268 |
| Details | Region: {"description":"Hexokinase small subdomain 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 478 |
| Details | Region: {"description":"Hexokinase large subdomain 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 268 |
| Details | Region: {"description":"Hexokinase small subdomain 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 478 |
| Details | Region: {"description":"Hexokinase large subdomain 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 42 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P19367","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 50 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29298880","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2NZT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26985301","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29298880","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2NZT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HG1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
