8GT6
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![BU of 8gt6 by Molmil](/molmil-images/mine/8gt6) | human STING With agonist HB3089 | 分子名称: | 1-[(2E)-4-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-[3-(morpholin-4-yl)propoxy]-1H-benzimidazol-1-yl}but-2-en-1-yl]-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methyl-1H-furo[3,2-e]benzimidazole-5-carboxamide, Stimulator of interferon genes protein | 著者 | Wang, Z, Yu, X. | 登録日 | 2022-09-07 | 公開日 | 2022-12-28 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation. Cell Discov, 8, 2022
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8GSZ
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![BU of 8gsz by Molmil](/molmil-images/mine/8gsz) | Structure of STING SAVI-related mutant V147L | 分子名称: | Stimulator of interferon genes protein | 著者 | Wang, Z, Yu, X. | 登録日 | 2022-09-07 | 公開日 | 2022-12-28 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | 主引用文献 | Structural insights into a shared mechanism of human STING activation by a potent agonist and an autoimmune disease-associated mutation. Cell Discov, 8, 2022
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5V61
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![BU of 5v61 by Molmil](/molmil-images/mine/5v61) | Phospho-ERK2 bound to bivalent inhibitor SBP2 | 分子名称: | 2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid, 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE, GLYCEROL, ... | 著者 | Lechtenberg, B.C, Riedl, S.J. | 登録日 | 2017-03-15 | 公開日 | 2017-07-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors. ACS Med Chem Lett, 8, 2017
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4LOP
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![BU of 4lop by Molmil](/molmil-images/mine/4lop) | Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form) | 分子名称: | 1,2-ETHANEDIOL, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, L(+)-TARTARIC ACID, ... | 著者 | Chaikuad, A, DeNicola, G.F, Krojer, T, Allerston, C.K, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Marber, M.S, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2013-07-13 | 公開日 | 2013-08-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | 主引用文献 | Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1. Nat.Struct.Mol.Biol., 20, 2013
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2IEW
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![BU of 2iew by Molmil](/molmil-images/mine/2iew) | |
5UMO
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![BU of 5umo by Molmil](/molmil-images/mine/5umo) | |
4KSE
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![BU of 4kse by Molmil](/molmil-images/mine/4kse) | Crystal structure of a HIV p51 (219-230) deletion mutant | 分子名称: | 1,2-ETHANEDIOL, HIV p51 subunit | 著者 | Zheng, X, Mueller, G.A, Derose, E.F, Pedersen, L.C, Gabel, S.A, Cuneo, M.J, Krahn, J.M, London, R.E. | 登録日 | 2013-05-17 | 公開日 | 2014-08-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.677 Å) | 主引用文献 | Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation. Nucleic Acids Res., 42, 2014
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6D5Y
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![BU of 6d5y by Molmil](/molmil-images/mine/6d5y) | |
4KA3
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![BU of 4ka3 by Molmil](/molmil-images/mine/4ka3) | Structure of MAP kinase in complex with a docking peptide | 分子名称: | Mitogen-activated protein kinase 14, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | 著者 | Xin, F.J, Wu, J.W. | 登録日 | 2013-04-22 | 公開日 | 2013-06-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.707 Å) | 主引用文献 | Crystal structure of the p38 alpha MAP kinase in complex with a docking peptide from TAB1 Sci China Life Sci, 56, 2013
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5V62
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![BU of 5v62 by Molmil](/molmil-images/mine/5v62) | Phospho-ERK2 bound to bivalent inhibitor SBP3 | 分子名称: | 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE, GLYCEROL, Mitogen-activated protein kinase 1, ... | 著者 | Lechtenberg, B.C, Riedl, S.J. | 登録日 | 2017-03-15 | 公開日 | 2017-07-26 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors. ACS Med Chem Lett, 8, 2017
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2IF8
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![BU of 2if8 by Molmil](/molmil-images/mine/2if8) | |
3BTV
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![BU of 3btv by Molmil](/molmil-images/mine/3btv) | |
5V60
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![BU of 5v60 by Molmil](/molmil-images/mine/5v60) | Phospho-ERK2 bound to AMP-PCP | 分子名称: | GLYCEROL, MAGNESIUM ION, Mitogen-activated protein kinase 1, ... | 著者 | Lechtenberg, B.C, Riedl, S.J. | 登録日 | 2017-03-15 | 公開日 | 2017-07-26 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors. ACS Med Chem Lett, 8, 2017
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6DCG
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![BU of 6dcg by Molmil](/molmil-images/mine/6dcg) | Discovery of MK-8353: An Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology | 分子名称: | (3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)-N-(3-{6-[(propan-2-yl)oxy]pyridin-3-yl}-1H-indazol-5-yl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | Boga, S.B, Deng, Y, Zhu, L, Nan, Y, Cooper, A, Shipps Jr, G.W, Doll, R, Shih, N, Zhu, H, Sun, R, Wang, T, Paliwal, S, Tsui, H, Gao, X, Yao, X, Desai, J, Wang, J, Alhassan, A.B, Kelly, J, Patel, M, Muppalla, K, Gudipati, S, Zhang, L, Buevich, A, Hesk, D, Carr, D, Dayananth, P, Mei, H, Cox, K, Sherborne, B, Hruza, A.W, Xiao, L, Jin, W, Long, B, Liu, G, Taylor, S.A, Kirschmeier, P, Windsor, W.T, Bishop, R, Samatar, A.A. | 登録日 | 2018-05-06 | 公開日 | 2018-08-08 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology. ACS Med Chem Lett, 9, 2018
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2GTM
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![BU of 2gtm by Molmil](/molmil-images/mine/2gtm) | Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579 | 分子名称: | 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM, Mitogen-activated protein kinase 14 | 著者 | Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Sabat, M. | 登録日 | 2006-04-28 | 公開日 | 2006-05-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production. Bioorg.Med.Chem.Lett., 16, 2006
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2Z9K
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2MA9
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![BU of 2ma9 by Molmil](/molmil-images/mine/2ma9) | HIV-1 Vif SOCS-box and Elongin BC solution structure | 分子名称: | Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, Virion infectivity factor | 著者 | Lu, Z, Bergeron, J.R, Atkinson, R.A, Schaller, T, Veselkov, D.A, Oregioni, A, Yang, Y, Matthews, S.J, Malim, M.H, Sanderson, M.R. | 登録日 | 2013-07-01 | 公開日 | 2013-12-11 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction. OPEN BIOLOGY, 3, 2013
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1FN7
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![BU of 1fn7 by Molmil](/molmil-images/mine/1fn7) | COUPLING OF DAMAGE RECOGNITION AND CATALYSIS BY A HUMAN BASE-EXCISION DNA REPAIR PROTEIN | 分子名称: | 8-OXOGUANINE DNA GLYCOSYLASE 1, CALCIUM ION, DNA (5'-D(*GP*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*CP*C)-3'), ... | 著者 | Norman, D.P.G, Bruner, S.D, Verdine, G.L. | 登録日 | 2000-08-21 | 公開日 | 2001-04-21 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Coupling of substrate recognition and catalysis by a human base-excision DNA repair protein. J.Am.Chem.Soc., 123, 2001
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3OXL
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![BU of 3oxl by Molmil](/molmil-images/mine/3oxl) | Human lysine methyltransferase Smyd3 in complex with AdoHcy (Form II) | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 3, ZINC ION | 著者 | Xu, S, Wu, J, Sun, B, Zhong, C, Ding, J. | 登録日 | 2010-09-21 | 公開日 | 2011-02-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Structural and biochemical studies of human lysine methyltransferase Smyd3 reveal the important functional roles of its post-SET and TPR domains and the regulation of its activity by DNA binding Nucleic Acids Res., 39, 2011
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5EAL
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![BU of 5eal by Molmil](/molmil-images/mine/5eal) | Crystal structure of human WDR5 in complex with compound 9h | 分子名称: | 1,2-ETHANEDIOL, 3-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-quinolin-3-yl-phenyl]benzamide, CHLORIDE ION, ... | 著者 | DONG, A, DOMBROVSKI, L, SMIL, D, GETLIK, M, BOLSHAN, Y, WALKER, J.R, SENISTERRA, G, PODA, G, AL-AWAR, R, SCHAPIRA, M, VEDADI, M, Bountra, C, Edwards, A.M, Arrowsmith, C.H, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | 登録日 | 2015-10-16 | 公開日 | 2015-11-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of human WDR5 in complex with compound 9h to be published
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8SPU
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![BU of 8spu by Molmil](/molmil-images/mine/8spu) | Structure of ESRRB nucleosome bound OCT4 at site c | 分子名称: | DNA (168-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | 著者 | Lian, T, Guan, R, Bai, Y. | 登録日 | 2023-05-03 | 公開日 | 2023-06-28 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural mechanism of LIN28B nucleosome targeting by OCT4. Mol.Cell, 83, 2023
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8SPS
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![BU of 8sps by Molmil](/molmil-images/mine/8sps) | High resolution structure of ESRRB nucleosome bound OCT4 at site a and site b | 分子名称: | DNA (168-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | 著者 | Lian, T, Guan, R, Bai, Y. | 登録日 | 2023-05-03 | 公開日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural mechanism of LIN28B nucleosome targeting by OCT4. Mol.Cell, 83, 2023
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5EAM
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![BU of 5eam by Molmil](/molmil-images/mine/5eam) | Crystal structure of human WDR5 in complex with compound 9o | 分子名称: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, ... | 著者 | DONG, A, DOMBROVSKI, L, SMIL, D, GETLIK, M, BOLSHAN, Y, WALKER, J.R, SENISTERRA, G, PODA, G, AL-AWAR, R, SCHAPIRA, M, VEDADI, M, Bountra, C, Edwards, A.M, Arrowsmith, C.H, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC) | 登録日 | 2015-10-16 | 公開日 | 2015-11-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J. Med. Chem., 59, 2016
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6WL5
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![BU of 6wl5 by Molmil](/molmil-images/mine/6wl5) | Crystal structure of EcmrR C-terminal domain | 分子名称: | 1,2-ETHANEDIOL, CETYL-TRIMETHYL-AMMONIUM, CHLORIDE ION, ... | 著者 | Yang, Y, Liu, C, Liu, B. | 登録日 | 2020-04-18 | 公開日 | 2021-04-07 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun, 12, 2021
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2BZE
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![BU of 2bze by Molmil](/molmil-images/mine/2bze) | NMR Structure of human RTF1 PLUS3 domain. | 分子名称: | KIAA0252 PROTEIN | 著者 | Truffault, V, Diercks, T, Ab, E, De Jong, R.N, Daniels, M.A, Kaptein, R, Folkers, G.E, Structural Proteomics in Europe (SPINE) | 登録日 | 2005-08-16 | 公開日 | 2007-01-03 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and DNA Binding of the Human Rtf1 Plus3 Domain. Structure, 16, 2008
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