PDB: 45953 件ウェブページステータス検索Chemie searchBIRD

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4G0U	Human topoisomerase IIbeta in complex with DNA and amsacrine 分子名称: DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA (5'-D(P*TP*GP*CP*AP*GP*CP*TP*CP*GP*GP*CP*T)-3'), DNA topoisomerase 2-beta, ... 著者 Wu, C.C, Li, T.K, Li, Y.C, Chan, N.L. 登録日 2012-07-10 公開日 2013-07-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs Nucleic Acids Res., 41, 2013
7VOU	The crystal structure of human forkhead box protein in complex with DNA 1 分子名称: DNA (5'-D(*AP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*T)-3'), Forkhead box protein L2 著者 Choi, Y, Yoon, H.J, Lee, H.H. 登録日 2021-10-14 公開日 2022-08-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Nucleic Acids Res., 50, 2022
2ZVK	Crystal structure of PCNA in complex with DNA polymerase eta fragment 分子名称: DNA polymerase eta, Proliferating cell nuclear antigen 著者 Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M. 登録日 2008-11-11 公開日 2009-02-10 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen J.Biol.Chem., 284, 2009
5ORM	Crystal structure of designed cPPR-Telo1 分子名称: cPPR-Telo1 著者 Spahr, H, Rackham, O. 登録日 2017-08-16 公開日 2018-06-20 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins. Nat Commun, 9, 2018
7VOX	The crystal structure of human forkhead box protein A in complex with DNA 2 分子名称: DNA (5'-D(P*AP*AP*AP*TP*AP*TP*TP*TP*AP*TP*TP*AP*TP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*AP*TP*AP*AP*TP*AP*AP*AP*TP*AP*TP*TP*T)-3'), Hepatocyte nuclear factor 3-alpha, ... 著者 Choi, Y, Yoon, H.J, Lee, H.H. 登録日 2021-10-15 公開日 2022-08-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Nucleic Acids Res., 50, 2022
5D8C	Crystal structure of HiNmlR, a MerR family regulator lacking the sensor domain, bound to promoter DNA 分子名称: DNA (5'-D(*CP*TP*TP*AP*GP*AP*GP*TP*GP*AP*AP*CP*TP*CP*TP*AP*AP*G)-3'), DNA (5'-D(*CP*TP*TP*AP*GP*AP*GP*TP*TP*CP*AP*CP*TP*CP*TP*AP*AP*G)-3'), MerR family regulator protein 著者 Counago, R.M, Chang, C.W, Chen, N.H, Djoko, K.Y, McEwan, A.G, Kobe, B. 登録日 2015-08-17 公開日 2016-06-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region. Nucleic Acids Res., 44, 2016
5D8L	Human HSF2 DNA Binding Domain in complex with 3-site HSE DNA at 2.1 Angstroms Resolution 分子名称: DNA (5'-D(*GP*GP*TP*TP*CP*TP*AP*GP*AP*AP*TP*AP*TP*TP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*AP*AP*TP*AP*TP*TP*CP*TP*AP*GP*AP*AP*CP*C)-3'), Heat shock factor protein 2 著者 Jaeger, A.M, Pemble, C.W, Thiele, D.J. 登録日 2015-08-17 公開日 2016-01-06 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.069 Å) 主引用文献 Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors. Nat.Struct.Mol.Biol., 23, 2016
4HID	Crystal Structure of Schizosaccharomyces pombe Pot1pC bound to ssDNA (GCTTACGGT) 分子名称: DNA (5'-D(*GP*CP*TP*TP*AP*CP*GP*GP*T)-3'), Protection of telomeres protein 1 著者 Dickey, T.H, Wuttke, D.S. 登録日 2012-10-11 公開日 2012-12-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.822 Å) 主引用文献 Nonspecific Recognition Is Achieved in Pot1pC through the Use of Multiple Binding Modes. Structure, 21, 2013
8GBJ	Cryo-EM structure of a human BCDX2/ssDNA complex 分子名称: DNA (5'-D(P*CP*CP*CP*CP*CP*C)-3'), DNA repair protein RAD51 homolog 2, DNA repair protein RAD51 homolog 3, ... 著者 Jia, L, Wasmuth, E.V, Ruben, E.A, Sung, P, Rawal, Y, Greene, E.C, Meir, A, Olsen, S.K. 登録日 2023-02-26 公開日 2023-06-21 最終更新日 2023-08-02 実験手法 ELECTRON MICROSCOPY (3.11 Å) 主引用文献 Structural insights into BCDX2 complex function in homologous recombination. Nature, 619, 2023
3CRO	THE PHAGE 434 CRO/OR1 COMPLEX AT 2.5 ANGSTROMS RESOLUTION 分子名称: DNA (5'-D(*AP*AP*GP*TP*AP*CP*AP*AP*AP*CP*TP*TP*TP*CP*TP*TP*G P*TP*AP*T)-3'), DNA (5'-D(*TP*AP*TP*AP*CP*AP*AP*GP*AP*AP*AP*GP*TP*TP*TP*GP*T P*AP*CP*T)-3'), PROTEIN (434 CRO) 著者 Mondragon, A, Harrison, S.C. 登録日 1990-07-06 公開日 1991-10-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The phage 434 Cro/OR1 complex at 2.5 A resolution. J.Mol.Biol., 219, 1991
7M09	Pre-catalytic quaternary complex of DNA Polymerase Lambda with blunt-ended DSB substrate and incoming dUMPNPP 分子名称: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CALCIUM ION, CHLORIDE ION, ... 著者 Kaminski, A.M, Bebenek, K, Pedersen, L.C, Kunkel, T.A. 登録日 2021-03-10 公開日 2022-03-16 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining. Nat Commun, 13, 2022
7M0A	Incomplete in crystallo incorporation by DNA Polymerase Lambda bound to blunt-ended DSB substrate and incoming dTTP 分子名称: CALCIUM ION, CHLORIDE ION, DNA (5'-D(*CP*AP*GP*TP*GP*CP*T)-3'), ... 著者 Kaminski, A.M, Bebenek, K, Pedersen, L.C, Kunkel, T.A. 登録日 2021-03-10 公開日 2022-03-16 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining. Nat Commun, 13, 2022
7M0D	Pre-catalytic quaternary complex of DNA Polymerase Lambda with bound complementary DSB substrate and incoming dUMPNPP 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... 著者 Kaminski, A.M, Bebenek, K, Pedersen, L.C, Kunkel, T.A. 登録日 2021-03-10 公開日 2022-03-16 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining. Nat Commun, 13, 2022
7M0B	Pre-catalytic quaternary complex of DNA Polymerase Lambda with bound mismatched DSB and incoming dUMPNPP 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, ... 著者 Kaminski, A.M, Bebenek, K, Pedersen, L.C, Kunkel, T.A. 登録日 2021-03-10 公開日 2022-03-16 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining. Nat Commun, 13, 2022
3E0C	Crystal Structure of DNA Damage-Binding protein 1(DDB1) 分子名称: DNA damage-binding protein 1 著者 Amaya, M.F, Xu, L, Hao, H, Bountra, C, Wickstroem, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) 登録日 2008-07-31 公開日 2008-09-16 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Structure and function of WD40 domain proteins. Protein Cell, 2, 2011
5EXH	Crystal structure of mTET3-CXXC domain in complex with 5-carboxylcytosine DNA at 1.3 Angstroms resolution. 分子名称: DNA (5'-D(*GP*AP*AP*TP*CP*(1CC)P*GP*GP*AP*TP*TP*C)-3'), Methylcytosine dioxygenase TET3, ZINC ION 著者 Song, J. 登録日 2015-11-23 公開日 2016-02-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration. Cell Rep, 14, 2016
1TRR	TANDEM BINDING IN CRYSTALS OF A TRP REPRESSOR/OPERATOR HALF-SITE COMPLEX 分子名称: DNA (5'-D(*AP*GP*CP*GP*TP*AP*CP*TP*AP*GP*TP*AP*CP*GP*CP*T)-3'), PROTEIN (TRP REPRESSOR), TRYPTOPHAN 著者 Lawson, C.L, Carey, J. 登録日 1993-10-21 公開日 1993-10-21 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Tandem binding in crystals of a trp repressor/operator half-site complex. Nature, 366, 1993
7M0E	Pre-catalytic synaptic complex of DNA Polymerase Lambda with gapped DSB substrate and incoming dUMPNPP 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, DNA (5'-D(*CP*AP*GP*TP*GP*C)-3'), ... 著者 Kaminski, A.M, Bebenek, K, Pedersen, L.C, Kunkel, T.A. 登録日 2021-03-10 公開日 2022-03-16 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining. Nat Commun, 13, 2022
7M07	Pre-catalytic ternary complex of DNA Polymerase Lambda with bound 1-nt gapped SSB substrate and incoming dUMPNPP 分子名称: 1,2-ETHANEDIOL, 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, ... 著者 Kaminski, A.M, Bebenek, K, Pedersen, L.C, Kunkel, T.A. 登録日 2021-03-10 公開日 2022-03-16 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining. Nat Commun, 13, 2022
4ZC0	Structure of a dodecameric bacterial helicase 分子名称: HEXATANTALUM DODECABROMIDE, Replicative DNA helicase 著者 Bazin, A, Cherrier, M.V, Gutsche, I, Timmins, J, Terradot, L. 登録日 2015-04-15 公開日 2015-10-21 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (6.7 Å) 主引用文献 Structure and primase-mediated activation of a bacterial dodecameric replicative helicase. Nucleic Acids Res., 43, 2015
1D3Y	STRUCTURE OF THE DNA TOPOISOMERASE VI A SUBUNIT 分子名称: DNA TOPOISOMERASE VI A SUBUNIT, MAGNESIUM ION, SODIUM ION 著者 Nichols, M.D, DeAngelis, K.A, Keck, J.L, Berger, J.M. 登録日 1999-10-01 公開日 1999-11-05 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure and function of an archaeal topoisomerase VI subunit with homology to the meiotic recombination factor Spo11. EMBO J., 18, 1999
5LV4	Crystal structure of mouse PRMT6 in complex with inhibitor LH1236 分子名称: (2~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]amino]-2-azanyl-butanoic acid, Protein arginine N-methyltransferase 6 著者 Cura, V, Marechal, N, Troffer-Charlier, N, Halby, L, Arimondo, P, Bonnefond, L, Cavarelli, J. 登録日 2016-09-12 公開日 2017-09-20 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors. Philos. Trans. R. Soc. Lond., B, Biol. Sci., 373, 2018
7ZVT	CryoEM structure of Ku heterodimer bound to DNA 分子名称: DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*T)-3'), DNA (5'-D(P*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*TP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ... 著者 Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. 登録日 2022-05-17 公開日 2023-05-24 最終更新日 2023-12-06 実験手法 ELECTRON MICROSCOPY (2.74 Å) 主引用文献 Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction. Nucleic Acids Res., 51, 2023
7ZWA	CryoEM structure of Ku heterodimer bound to DNA and PAXX 分子名称: DNA (5'-D(P*CP*GP*AP*TP*AP*TP*CP*TP*AP*GP*AP*GP*GP*GP*AP*TP*C)-3'), DNA (5'-D(P*GP*AP*TP*CP*CP*CP*TP*CP*TP*AP*GP*AP*TP*AP*T)-3'), PHOSPHATE ION, ... 著者 Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. 登録日 2022-05-19 公開日 2023-05-31 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv, 9, 2023
7ZYG	CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF 分子名称: DNA, Non-homologous end-joining factor 1, PHOSPHATE ION, ... 著者 Hardwick, S.W, Kefala-Stavridi, A, Chirgadze, D.Y, Blundell, T.L, Chaplin, A.K. 登録日 2022-05-24 公開日 2023-06-07 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (2.68 Å) 主引用文献 PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Sci Adv, 9, 2023

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