7M0E

Pre-catalytic synaptic complex of DNA Polymerase Lambda with gapped DSB substrate and incoming dUMPNPP

Summary for 7M0E

• Entry DOI: 10.2210/pdb7m0e/pdb
• Descriptor: DNA polymerase lambda, DNA (5'-D(*CP*GP*GP*CP*AP*GP*C)-3'), DNA (5'-D(*CP*AP*GP*TP*GP*C)-3'), ... (10 entities in total)
• Functional Keywords: nonhomologous end-joining, base excision repair, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 16
• Total formula weight: 177797.09

Authors

Kaminski, A.M.,Bebenek, K.,Pedersen, L.C.,Kunkel, T.A. (deposition date: 2021-03-10, release date: 2022-03-16, Last modification date: 2023-10-25)

• Primary citation: Kaminski, A.M.,Chiruvella, K.K.,Ramsden, D.A.,Bebenek, K.,Kunkel, T.A.,Pedersen, L.C.; Analysis of diverse double-strand break synapsis with Pol lambda reveals basis for unique substrate specificity in nonhomologous end-joining.; Nat Commun, 13:3806-3806, 2022; PubMed: 35778389; DOI: 10.1038/s41467-022-31278-4

Experimental method

X-RAY DIFFRACTION (2.25 Å)