PDB: 46984 件ウェブページステータス検索Chemie searchBIRD

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3SM4	Crystal Structure of the K131A Mutant of Lambda Exonuclease in Complex with a 5'-Phosphorylated 14-mer/12-mer Duplex and Magnesium 分子名称: 5'-D(*TP*CP*GP*GP*TP*AP*CP*AP*GP*TP*AP*G)-3', 5'-D(P*AP*GP*CP*TP*AP*CP*TP*GP*TP*AP*CP*CP*GP*A)-3', CHLORIDE ION, ... 著者 Bell, C.E, Zhang, J. 登録日 2011-06-27 公開日 2011-07-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Crystal structures of {lambda} exonuclease in complex with DNA suggest an electrostatic ratchet mechanism for processivity. Proc.Natl.Acad.Sci.USA, 108, 2011
3A25	Crystal structure of P. horikoshii TYW2 in complex with AdoMet 分子名称: S-ADENOSYLMETHIONINE, Uncharacterized protein PH0793 著者 Umitsu, M, Nishimasu, H, Ishitani, R, Nureki, O. 登録日 2009-04-28 公開日 2009-09-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2 Proc.Natl.Acad.Sci.USA, 106, 2009
4N8D	DPP4 complexed with syn-7aa 分子名称: 1-(cis-1-phenyl-4-{[(2E)-3-phenylprop-2-en-1-yl]oxy}cyclohexyl)methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ... 著者 Ostermann, N, Zink, F, Kroemer, M. 登録日 2013-10-17 公開日 2014-02-12 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV. Bioorg.Med.Chem.Lett., 24, 2014
4NES	Crystal structure of Methanocaldococcus jannaschii UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP 分子名称: UDP-N-acetylglucosamine 2-epimerase, URIDINE-5'-DIPHOSPHATE, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE 著者 Chen, S.C, Yang, C.S, Huang, C.H, Chen, Y. 登録日 2013-10-30 公開日 2014-04-23 最終更新日 2015-06-17 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Crystal structures of the archaeal UDP-GlcNAc 2-epimerase from Methanocaldococcus jannaschii reveal a conformational change induced by UDP-GlcNAc. Proteins, 82, 2014
6HP8	Crystal structure of DPP8 in complex with Val-BoroPro 分子名称: Dipeptidyl peptidase 8, GLYCEROL, SODIUM ION, ... 著者 Ross, B.H, Huber, R. 登録日 2018-09-19 公開日 2019-07-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Improvement of Protein Crystal Diffraction Using Post-Crystallization Methods: Infrared Laser Radiation Controls Crystal Order Thesis, 2019
2XKC	Structure of Nek2 bound to aminopyrazine compound 14 分子名称: 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-methylbenzoic acid, CHLORIDE ION, SERINE/THREONINE-PROTEIN KINASE NEK2 著者 Mas-Droux, C, Bayliss, R. 登録日 2010-07-07 公開日 2010-10-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: Sar and Structural Characterization. J.Med.Chem., 53, 2010
3MGU	Structure of S. cerevisiae Tpa1 protein, a proline hydroxylase modifying ribosomal protein Rps23 分子名称: FE (II) ION, PKHD-type hydroxylase TPA1 著者 Henri, J, Rispal, D, Bayart, E, van Tilbeurgh, H, Seraphin, B, Graille, M. 登録日 2010-04-07 公開日 2010-07-14 最終更新日 2018-01-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural and functional insights into S. cerevisiae Tpa1, a putative prolyl hydroxylase influencing translation termination and transcription To be Published
8GJX	Structure of the human STING receptor bound to 2'3'-cUA 分子名称: 2'3'-cUA, Stimulator of interferon genes protein 著者 Morehouse, B.R, Li, Y, Slavik, K.M, Toyoda, H, Kranzusch, P.J. 登録日 2023-03-16 公開日 2023-07-05 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell, 186, 2023
2XSH	CRYSTAL STRUCTURE OF P4 VARIANT OF BIPHENYL DIOXYGENASE FROM BURKHOLDERIA XENOVORANS LB400 IN COMPLEX WITH 2,6 DI CHLOROBIPHENYL 分子名称: 2,6-DICHLOROBIPHENYL, BIPHENYL DIOXYGENASE SUBUNIT ALPHA, BIPHENYL DIOXYGENASE SUBUNIT BETA, ... 著者 Kumar, P, Bolin, J.T. 登録日 2010-09-29 公開日 2010-11-24 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Structural Insight Into the Expanded Pcb-Degrading Abilities of a Biphenyl Dioxygenase Obtained by Directed Evolution. J.Mol.Biol., 405, 2011
8FBB	LH2-LH3 antenna in parallel configuration embedded in a nanodisc 分子名称: BACTERIOCHLOROPHYLL A, LYCOPENE, Light-harvesting protein B-800/850 alpha chain, ... 著者 Toporik, H, Harris, D, Schlau-Cohen, G.S, Mazor, Y. 登録日 2022-11-29 公開日 2023-07-19 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (11.3 Å) 主引用文献 Elucidating interprotein energy transfer dynamics within the antenna network from purple bacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
1NSI	HUMAN INDUCIBLE NITRIC OXIDE SYNTHASE, ZN-BOUND, L-ARG COMPLEX 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, ARGININE, GLYCEROL, ... 著者 Li, H, Raman, C.S, Glaser, C.B, Blasko, E, Young, T.A, Parkinson, J.F, Whitlow, M, Poulos, T.L. 登録日 1999-01-10 公開日 2000-01-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase. J.Biol.Chem., 274, 1999
4YXW	Bovine heart mitochondrial F1-ATPase inhibited by AMP-PNP and ADP in the presence of thiophosphate. 分子名称: ATP synthase subunit alpha, mitochondrial, ATP synthase subunit beta, ... 著者 Bason, J.V, Montgomery, M.G, Leslie, A.G.W, Walker, J.E. 登録日 2015-03-23 公開日 2015-05-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 How release of phosphate from mammalian F1-ATPase generates a rotary substep. Proc.Natl.Acad.Sci.USA, 112, 2015
3K2O	Structure of an oxygenase 分子名称: ACETATE ION, Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, CHLORIDE ION, ... 著者 Krojer, T, McDonough, M.A, Clifton, I.J, Mantri, M, Ng, S.S, Pike, A.C.W, Butler, D.S, Webby, C.J, Kochan, G, Bhatia, C, Bray, J.E, Chaikuad, A, Gileadi, O, von Delft, F, Weigelt, J, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Schofield, C.J, Kavanagh, K.L, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2009-09-30 公開日 2009-11-03 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6. J.Mol.Biol., 401, 2010
8GJZ	Structure of a STING receptor from S. pistillata Sp-STING1 bound to 2'3'-cUA 分子名称: 2'3'-cUA, Stimulator of interferon genes protein 著者 Li, Y, Toyoda, H, Slavik, K.M, Morehouse, B.R, Kranzusch, P.J. 登録日 2023-03-16 公開日 2023-07-05 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell, 186, 2023
4NH5	Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 14-mer siRNA having 5'-pUU and UU-3' ends (2.55 Angstrom resolution) 分子名称: 5'-R(P*UP*UP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3', Endoribonuclease Dicer 著者 Tian, Y, Simanshu, D.K, Patel, D.J. 登録日 2013-11-04 公開日 2014-03-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer. Mol.Cell, 53, 2014
8GU7	Selective targeting of the Beclin 2-Atg14L coiled coil complex by stapled peptides promotes autophagy and endolysosomal trafficking of GPCRs 分子名称: Beclin 1-associated autophagy-related key regulator, Beclin-2 著者 Qiu, X, Zhao, Y. 登録日 2022-09-11 公開日 2023-07-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs. Autophagy, 19, 2023
2XSO	CRYSTAL STRUCTURE OF P4 VARIANT OF BIPHENYL DIOXYGENASE FROM BURKHOLDERIA XENOVORANS LB400 分子名称: BIPHENYL DIOXYGENASE SUBUNIT ALPHA, BIPHENYL DIOXYGENASE SUBUNIT BETA, FE (II) ION, ... 著者 Kumar, P, Bolin, J.T. 登録日 2010-09-29 公開日 2010-11-24 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Insight Into the Expanded Pcb-Degrading Abilities of a Biphenyl Dioxygenase Obtained by Directed Evolution. J.Mol.Biol., 405, 2011
6OOE	CTX-M-27 Beta Lactamase with Compound 20 分子名称: 3-(1H-tetrazol-5-yl)-N-[3-(1H-tetrazol-5-yl)phenyl]-5-(trifluoromethyl)benzamide, Beta-lactamase 著者 Kemp, M, Chen, Y. 登録日 2019-04-23 公開日 2020-07-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 An Empirical Study of Amide-Heteroarene pi-Stacking Interactions Using Reversible Inhibitors of a Bacterial Serine Hydrolase. Org Chem Front, 6, 2019
6H0Z	Crystal Structure of KDM4D with tetrazolylhydrazide ligand NR067 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Lysine-specific demethylase 4D, ... 著者 Malecki, P.H, Weiss, M.S, Heinemann, U, Link, A. 登録日 2018-07-10 公開日 2020-01-29 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.34 Å) 主引用文献 Crystal Structure of KDM4D with tetrazolylhydrazide ligand NR067 To be published
8GO3	Cryo-EM structure of Escherichia coli cytochrome bo3 in DDM detergent 分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, COPPER (II) ION, Cytochrome bo(3) ubiquinol oxidase subunit 1, ... 著者 Cao, H.Y, Li, K, Li, C.Y. 登録日 2022-08-24 公開日 2023-08-30 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Cryo-EM structure of Escherichia coli cytochrome bo3 in DDM detergent To Be Published
3A5D	Inter-subunit interaction and quaternary rearrangement defined by the central stalk of prokaryotic V1-ATPase 分子名称: V-type ATP synthase alpha chain, V-type ATP synthase beta chain, V-type ATP synthase subunit D, ... 著者 Numoto, N, Hasegawa, Y, Takeda, K, Miki, K. 登録日 2009-08-06 公開日 2009-10-13 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (4.8 Å) 主引用文献 Inter-subunit interaction and quaternary rearrangement defined by the central stalk of prokaryotic V1-ATPase Embo Rep., 10, 2009
3K3J	P38alpha bound to novel DFG-out compound PF-00416121 分子名称: 2-(4-fluorophenyl)-3-oxo-6-pyridin-4-yl-N-[2-(trifluoromethyl)benzyl]-2,3-dihydropyridazine-4-carboxamide, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, Mitogen-activated protein kinase 14 著者 Kazmirski, S.L, DiNitto, J.P. 登録日 2009-10-02 公開日 2009-11-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.995 Å) 主引用文献 The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG-out Conformation of p38alpha for High Throughput Screening Binding Assay. Chem.Biol.Drug Des., 74, 2009
8G9B	Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; compressed filament segment reconstruction 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... 著者 O'Neill, A.G, Kollman, J.M. 登録日 2023-02-21 公開日 2023-04-19 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
8G8F	Human IMPDH2 mutant - L245P, treated with ATP, IMP, and NAD+; extended filament segment reconstruction 分子名称: ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, ... 著者 O'Neill, A.G, Kollman, J.M. 登録日 2023-02-17 公開日 2023-04-19 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
4OJN	Crystal structure of human muscle L-lactate dehydrogenase 分子名称: GLYCEROL, L-lactate dehydrogenase A chain, PENTAETHYLENE GLYCOL 著者 Kolappan, S, Craig, L. 登録日 2014-01-21 公開日 2014-12-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallogr.,Sect.D, 71, 2015

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