7B5E
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![BU of 7b5e by Molmil](/molmil-images/mine/7b5e) | Structure of calcium-bound mTMEM16A(ac)-I551A chloride channel at 4.1 A resolution | 分子名称: | Anoctamin-1, CALCIUM ION | 著者 | Lam, A.K.M, Rheinberger, J, Paulino, C, Dutzler, R. | 登録日 | 2020-12-03 | 公開日 | 2021-02-10 | 最終更新日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Gating the pore of the calcium-activated chloride channel TMEM16A. Nat Commun, 12, 2021
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7B5D
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7B5C
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![BU of 7b5c by Molmil](/molmil-images/mine/7b5c) | Structure of calcium-bound mTMEM16A(ac) chloride channel at 3.7 A resolution | 分子名称: | Anoctamin-1, CALCIUM ION | 著者 | Lam, A.K.M, Rheinberger, J, Paulino, C, Dutzler, R. | 登録日 | 2020-12-03 | 公開日 | 2021-02-10 | 最終更新日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Gating the pore of the calcium-activated chloride channel TMEM16A. Nat Commun, 12, 2021
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7AUZ
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![BU of 7auz by Molmil](/molmil-images/mine/7auz) | LTA4 hydrolase in complex with compound LYS006 | 分子名称: | (3~{S})-3-azanyl-4-[5-[4-(5-chloranyl-3-fluoranyl-pyridin-2-yl)oxyphenyl]-1,2,3,4-tetrazol-2-yl]butanoic acid, ACETATE ION, IMIDAZOLE, ... | 著者 | Srinivas, H. | 登録日 | 2020-11-03 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64, 2021
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7AV0
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![BU of 7av0 by Molmil](/molmil-images/mine/7av0) | LTA4 hydrolase in complex with compound R(13) | 分子名称: | (3~{R})-3-azanyl-4-[5-[4-(4-chloranylphenoxy)phenyl]-1,2,3,4-tetrazol-2-yl]butanoic acid, ACETATE ION, IMIDAZOLE, ... | 著者 | Srinivas, H. | 登録日 | 2020-11-03 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64, 2021
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7AV2
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![BU of 7av2 by Molmil](/molmil-images/mine/7av2) | LTA4 hydrolase in complex with fragment1 | 分子名称: | (4-phenoxyphenyl)methanol, ACETATE ION, IMIDAZOLE, ... | 著者 | Srinivas, H. | 登録日 | 2020-11-03 | 公開日 | 2021-02-17 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A 4 Hydrolase. J.Med.Chem., 64, 2021
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7BVQ
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![BU of 7bvq by Molmil](/molmil-images/mine/7bvq) | Structure of human beta1 adrenergic receptor bound to carazolol | 分子名称: | (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, CHOLESTEROL, ... | 著者 | Xu, X, Kaindl, J, Clark, M, Hubner, H, Hirata, K, Sunahara, R, Gmeiner, P, Kobilka, B.K, Liu, X. | 登録日 | 2020-04-11 | 公開日 | 2020-12-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Binding pathway determines norepinephrine selectivity for the human beta 1 AR over beta 2 AR. Cell Res., 31, 2021
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7BU6
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![BU of 7bu6 by Molmil](/molmil-images/mine/7bu6) | Structure of human beta1 adrenergic receptor bound to norepinephrine and nanobody 6B9 | 分子名称: | (2S)-2,3-dihydroxypropyl octanoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHOLESTEROL, ... | 著者 | Xu, X, Kaindl, J, Clark, M, Hubner, H, Hirata, K, Sunahara, R, Gmeiner, P, Kobilka, B.K, Liu, X. | 登録日 | 2020-04-04 | 公開日 | 2020-12-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Binding pathway determines norepinephrine selectivity for the human beta 1 AR over beta 2 AR. Cell Res., 31, 2021
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7BTS
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![BU of 7bts by Molmil](/molmil-images/mine/7bts) | Structure of human beta1 adrenergic receptor bound to epinephrine and nanobody 6B9 | 分子名称: | (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHOLESTEROL, ... | 著者 | Xu, X, Kaindl, J, Clark, M, Hubner, H, Hirata, K, Sunahara, R, Gmeiner, P, Kobilka, B.K, Liu, X. | 登録日 | 2020-04-02 | 公開日 | 2020-12-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | 主引用文献 | Binding pathway determines norepinephrine selectivity for the human beta 1 AR over beta 2 AR. Cell Res., 31, 2021
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1SM3
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![BU of 1sm3 by Molmil](/molmil-images/mine/1sm3) | CRYSTAL STRUCTURE OF THE TUMOR SPECIFIC ANTIBODY SM3 COMPLEX WITH ITS PEPTIDE EPITOPE | 分子名称: | CADMIUM ION, CHLORIDE ION, PEPTIDE EPITOPE, ... | 著者 | Dokurno, P, Bates, P.A, Band, H.A, Stewart, L.M.D, Lally, J.M, Burchell, J.M, Taylor-Papadimitriou, J, Sternberg, M.J.E, Snary, D, Freemont, P.S. | 登録日 | 1997-12-23 | 公開日 | 1999-03-23 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure at 1.95 A resolution of the breast tumour-specific antibody SM3 complexed with its peptide epitope reveals novel hypervariable loop recognition. J.Mol.Biol., 284, 1998
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7BBT
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![BU of 7bbt by Molmil](/molmil-images/mine/7bbt) | Structure of cytochrome c in complex with a p-benzyl-sulfonato-calix[8]arene-PEG pseudorotaxane | 分子名称: | 4-[[49,50,51,52,53,54,55,56-octahydroxy-11,17,23,29,35,41,47-heptakis[(4-sulfonatophenyl)methyl]-5-nonacyclo[43.3.1.13,7.19,13.115,19.121,25.127,31.133,37.139,43]hexapentaconta-1(49),3,5,7(56),9,11,13(55),15,17,19(54),21,23,25(53),27,29,31(52),33,35,37(51),39,41,43(50),45,47-tetracosaenyl]methyl]benzenesulfonate, Cytochrome c iso-1, HEME C, ... | 著者 | Mockler, N.M, Ramberg, K, Guagnini, F, Raston, C.L, Crowley, P.B. | 登録日 | 2020-12-18 | 公開日 | 2021-10-20 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.023 Å) | 主引用文献 | Noncovalent Protein-Pseudorotaxane Assembly Incorporating an Extended Arm Calix[8]arene with alpha-Helical Recognition Properties. Cryst.Growth Des., 21, 2021
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7TR8
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![BU of 7tr8 by Molmil](/molmil-images/mine/7tr8) | Cascade complex from type I-A CRISPR-Cas system | 分子名称: | CRISPR-associated endonuclease Cas3-HD, CRISPR-associated helicase Cas3, Cas11a, ... | 著者 | Hu, C, Ni, D, Nam, K.H, Majumdar, S, McLean, J, Stahlberg, H, Terns, M, Ke, A. | 登録日 | 2022-01-28 | 公開日 | 2022-08-10 | 最終更新日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools. Mol.Cell, 82, 2022
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7TRA
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![BU of 7tra by Molmil](/molmil-images/mine/7tra) | Cascade complex from type I-A CRISPR-Cas system | 分子名称: | CRISPR-associated endonuclease Cas3-HD, CRISPR-associated helicase Cas3, Cas11a, ... | 著者 | Hu, C, Ni, D, Nam, K.H, Majumdar, S, McLean, J, Stahlberg, H, Terns, M, Ke, A. | 登録日 | 2022-01-28 | 公開日 | 2022-08-10 | 最終更新日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools. Mol.Cell, 82, 2022
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7TR9
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![BU of 7tr9 by Molmil](/molmil-images/mine/7tr9) | Cascade complex from type I-A CRISPR-Cas system | 分子名称: | CRISPR-associated endonuclease Cas3-HD, CRISPR-associated helicase Cas3, Cas11a, ... | 著者 | Hu, C, Ni, D, Nam, K.H, Majumdar, S, McLean, J, Stahlberg, H, Terns, M, Ke, A. | 登録日 | 2022-01-28 | 公開日 | 2022-08-10 | 最終更新日 | 2022-08-24 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools. Mol.Cell, 82, 2022
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6C3F
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6C88
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7BBN
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7UXU
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![BU of 7uxu by Molmil](/molmil-images/mine/7uxu) | CryoEM structure of the TIR domain from AbTir in complex with 3AD | 分子名称: | Molecular chaperone Tir, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(8-azanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | 著者 | Li, S, Nanson, J.D, Manik, M.K, Gu, W, Landsberg, M.J, Ve, T, Kobe, B. | 登録日 | 2022-05-06 | 公開日 | 2022-09-07 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling. Science, 377, 2022
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7UNM
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![BU of 7unm by Molmil](/molmil-images/mine/7unm) | Human TMEM175 in an closed state | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, POTASSIUM ION | 著者 | Oh, S, Hite, R.K. | 登録日 | 2022-04-11 | 公開日 | 2022-06-29 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | 主引用文献 | Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K + channel TMEM175. Elife, 11, 2022
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7V3D
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7TR6
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![BU of 7tr6 by Molmil](/molmil-images/mine/7tr6) | Cascade complex from type I-A CRISPR-Cas system | 分子名称: | Cas11a, Cas5a, Cas7a, ... | 著者 | Hu, C, Ni, D, Nam, K.H, Majumdar, S, McLean, J, Stahlberg, H, Terns, M, Ke, A. | 登録日 | 2022-01-28 | 公開日 | 2022-08-10 | 最終更新日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools. Mol.Cell, 82, 2022
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3MN1
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![BU of 3mn1 by Molmil](/molmil-images/mine/3mn1) | Crystal structure of probable yrbi family phosphatase from pseudomonas syringae pv.phaseolica 1448a | 分子名称: | CHLORIDE ION, probable yrbi family phosphatase | 著者 | Patskovsky, Y, Ramagopal, U, Toro, R, Freeman, J, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2010-04-20 | 公開日 | 2010-04-28 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural basis for the divergence of substrate specificity and biological function within HAD phosphatases in lipopolysaccharide and sialic acid biosynthesis. Biochemistry, 52, 2013
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7UMS
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![BU of 7ums by Molmil](/molmil-images/mine/7ums) | Structure of the VP5*/VP8* assembly from the human rotavirus strain CDC-9 in complex with antibody 41 - Upright conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Fab 41 heavy chain, ... | 著者 | Jenni, S, Zongli, L, Wang, Y, Bessey, T, Salgado, E.N, Schmidt, A.G, Greenberg, H.B, Jiang, B, Harrison, S.C. | 登録日 | 2022-04-07 | 公開日 | 2022-07-27 | 最終更新日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Rotavirus VP4 Epitope of a Broadly Neutralizing Human Antibody Defined by Its Structure Bound with an Attenuated-Strain Virion. J.Virol., 96, 2022
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7UMT
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![BU of 7umt by Molmil](/molmil-images/mine/7umt) | Structure of the VP5*/VP8* assembly from the human rotavirus strain CDC-9 - Reversed conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Intermediate capsid protein VP6, ... | 著者 | Jenni, S, Zongli, L, Wang, Y, Bessey, T, Salgado, E.N, Schmidt, A.G, Greenberg, H.B, Jiang, B, Harrison, S.C. | 登録日 | 2022-04-07 | 公開日 | 2022-07-27 | 最終更新日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Rotavirus VP4 Epitope of a Broadly Neutralizing Human Antibody Defined by Its Structure Bound with an Attenuated-Strain Virion. J.Virol., 96, 2022
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7BU7
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![BU of 7bu7 by Molmil](/molmil-images/mine/7bu7) | Structure of human beta1 adrenergic receptor bound to BI-167107 and nanobody 6B9 | 分子名称: | (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one, ... | 著者 | Xu, X, Kaindl, J, Clark, M, Hubner, H, Hirata, K, Sunahara, R, Gmeiner, P, Kobilka, B.K, Liu, X. | 登録日 | 2020-04-04 | 公開日 | 2020-12-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Binding pathway determines norepinephrine selectivity for the human beta 1 AR over beta 2 AR. Cell Res., 31, 2021
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