7TR9

Cascade complex from type I-A CRISPR-Cas system

This is a non-PDB format compatible entry.

Summary for 7TR9

• Entry DOI: 10.2210/pdb7tr9/pdb
• EMDB information: 26083
• Descriptor: Cas8a, NICKEL (II) ION, Cas11a, ... (10 entities in total)
• Functional Keywords: crispr, cascade, cas3, type i-a, genome editing, rna binding protein
• Biological source: Pyrococcus furiosus DSM 3638; More
• Total number of polymer chains: 19
• Total formula weight: 499218.79

Authors

Hu, C.,Ni, D.,Nam, K.H.,Majumdar, S.,McLean, J.,Stahlberg, H.,Terns, M.,Ke, A. (deposition date: 2022-01-28, release date: 2022-08-10, Last modification date: 2022-08-24)

• Primary citation: Hu, C.,Ni, D.,Nam, K.H.,Majumdar, S.,McLean, J.,Stahlberg, H.,Terns, M.P.,Ke, A.; Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools.; Mol.Cell, 82:2754-2768.e5, 2022; PubMed: 35835111; DOI: 10.1016/j.molcel.2022.06.007

Experimental method

ELECTRON MICROSCOPY (3.9 Å)