7TR9

Cascade complex from type I-A CRISPR-Cas system

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (C)	Cas8a	polymer	341	38800.7	1	UniProt (Q8U338) Pfam (PF09703)	Pyrococcus furiosus DSM 3638
2	B, C, D, E, F (D, E, F, G, H)	Cas11a	polymer	108	12208.9	5	UniProt (Q8U332)	Pyrococcus furiosus DSM 3638
3	G, H, I, J, K... (I, J, K, L, M...)	Cas7a	polymer	336	36989.1	7	UniProt (Q8U333) Pfam (PF01905)	Pyrococcus furiosus DSM 3638
4	N (P)	Cas5a	polymer	256	29147.2	1	UniProt (A0A5C0XNV9)	Pyrococcus furiosus DSM 3638
5	O (R)	crRNA (45-MER)	polymer	45	14373.5	1		Escherichia coli
6	P (A)	CRISPR-associated helicase Cas3	polymer	572	61412.6	1		Pyrococcus furiosus DSM 3638
7	Q (Q)	CRISPR-associated endonuclease Cas3-HD	polymer	237	26057.6	1		Pyrococcus furiosus DSM 3638
8	R (S)	Target strand DNA	polymer	22	6929.4	1		Escherichia coli
9	S (T)	Non-Target strand DNA	polymer	8	2411.6	1		Escherichia coli
10	T, U (Q)	NICKEL (II) ION	non-polymer		58.7	2	Chemie (NI)

Sequence modifications

C: 2 - 342 (UniProt: Q8U338)

PDB	External Database	Details
Val 24	Glu 25	conflict
Ser 64	Glu 65	conflict
Leu 110	Val 111	conflict
-	Ser 235	deletion
-	Leu 236	deletion
-	Gly 237	deletion

P: 1 - 256 (UniProt: A0A5C0XNV9)

PDB	External Database	Details
-	Thr 235	deletion

Contents of the asymmetric unit

Polymers	Number of chains	19
	Total formula weight	499101.4
Non-Polymers*	Number of molecules	2
	Total formula weight	117.4
All*	Total formula weight	499218.8

*Water molecules are not included.