7UXU

CryoEM structure of the TIR domain from AbTir in complex with 3AD

Summary for 7UXU

• Entry DOI: 10.2210/pdb7uxu/pdb
• EMDB information: 26862
• Descriptor: Molecular chaperone Tir, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(8-azanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate (2 entities in total)
• Functional Keywords: 2' cadpr, nadase, bacterial tir, hydrolase
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 4
• Total formula weight: 65204.08

Authors

Li, S.,Nanson, J.D.,Manik, M.K.,Gu, W.,Landsberg, M.J.,Ve, T.,Kobe, B. (deposition date: 2022-05-06, release date: 2022-09-07, Last modification date: 2022-10-12)

• Primary citation: Manik, M.K.,Shi, Y.,Li, S.,Zaydman, M.A.,Damaraju, N.,Eastman, S.,Smith, T.G.,Gu, W.,Masic, V.,Mosaiab, T.,Weagley, J.S.,Hancock, S.J.,Vasquez, E.,Hartley-Tassell, L.,Kargios, N.,Maruta, N.,Lim, B.Y.J.,Burdett, H.,Landsberg, M.J.,Schembri, M.A.,Prokes, I.,Song, L.,Grant, M.,DiAntonio, A.,Nanson, J.D.,Guo, M.,Milbrandt, J.,Ve, T.,Kobe, B.; Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling.; Science, 377:eadc8969-eadc8969, 2022; PubMed: 36048923; DOI: 10.1126/science.adc8969

Experimental method

ELECTRON MICROSCOPY (2.74 Å)