7WN4
 
 | | Cryo-EM structure of VWF D'D3 dimer (wild type) complexed with D1D2 at 3.4 angstron resolution (1 unit) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, von Willebrand antigen 2, ... | | 著者 | Zeng, J.W, Shu, Z.M, Zhou, A.W. | | 登録日 | 2022-01-17 | | 公開日 | 2022-05-18 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural mechanism of VWF D'D3 dimer formation.
Cell Discov, 8, 2022
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7WN3
 | | Cryo-EM structure of VWF D'D3 dimer (2M mutant) complexed with D1D2 at 3.29 angstron resolution (2 units) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, von Willebrand antigen 2, ... | | 著者 | Zeng, J.W, Shu, Z.M, Zhou, A.W. | | 登録日 | 2022-01-17 | | 公開日 | 2022-05-25 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Structural mechanism of VWF D'D3 dimer formation.
Cell Discov, 8, 2022
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7WHB
 | | SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (3U) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Zeng, J.W, Ge, J.W, Wang, X.Q. | | 登録日 | 2021-12-30 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (2.67 Å) | | 主引用文献 | SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters 1 .
Emerg Microbes Infect, 12, 2023
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7WHD
 | | SARS-CoV-2 spike in complex with the ZB8 neutralizing antibody Fab (2u1d) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | | 著者 | Zeng, J.W, Wang, X.W, Ge, J.W, Wang, Z.Y. | | 登録日 | 2021-12-30 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | | 主引用文献 | SARS-CoV-2 hijacks neutralizing dimeric IgA for nasal infection and injury in Syrian hamsters 1 .
Emerg Microbes Infect, 12, 2023
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7X2A
 | | MERS-CoV spike complex with S41 neutralizing antibody Fab Class1 (1u2d RBD with 1Fab) | | 分子名称: | MERS-CoV Spike glycoprotein, antibody S41 heavy chain, antibody S41 light chain | | 著者 | Zeng, J.W, Zhang, S.Y, Zhou, H.X, Wang, X.W. | | 登録日 | 2022-02-25 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-11-23 | | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | | 主引用文献 | Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein.
Front Microbiol, 13, 2022
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7X26
 | | S41 neutralizing antibody Fab(MERS-CoV) | | 分子名称: | Spike glycoprotein, antibody S41 heavy chain, antibody S41 light chain | | 著者 | Zeng, J.W, Zhang, S.Y, Wang, X.W. | | 登録日 | 2022-02-25 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-11-23 | | 実験手法 | ELECTRON MICROSCOPY (3.685 Å) | | 主引用文献 | Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein.
Front Microbiol, 13, 2022
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7X29
 | | MERS-CoV spike complex with S41 neutralizing antibody Fab Class2 (1u2d RBD with 2Fab) | | 分子名称: | Spike glycoprotein, antibody S41 heavy chain, antibody S41 light chain | | 著者 | Zeng, J.W, Zhang, S.Y, Zhou, H.X, Wang, X.W. | | 登録日 | 2022-02-25 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-11-23 | | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | | 主引用文献 | Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein.
Front Microbiol, 13, 2022
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7X28
 | | MERS-CoV spike complex with S41 neutralizing antibody Fab Class3 (2u1d RBD with 2Fab) | | 分子名称: | Spike glycoprotein, antibody S41 heavy chain, antibody S41 light chain | | 著者 | Zeng, J.W, Zhang, S.Y, Zhou, H.X, Wang, X.W. | | 登録日 | 2022-02-25 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-01-25 | | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | | 主引用文献 | Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein.
Front Microbiol, 13, 2022
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7WH8
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5XV7
 | | SRPK1 in complex with Alectinib | | 分子名称: | 1,2-ETHANEDIOL, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, serine-arginine (SR) protein kinase 1 | | 著者 | Zeng, C, Ngo, J.C.K. | | 登録日 | 2017-06-26 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform
Cell Chem Biol, 25, 2018
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7X25
 | | MERS-CoV spike complex with S41 neutralizing antibody Fab Class4 (2u1d RBD with 3Fab) | | 分子名称: | Spike glycoprotein, antibody S41 heavy chain, antibody S41 light chain | | 著者 | Zeng, J, Zhang, S, Zhou, H, Wang, X. | | 登録日 | 2022-02-25 | | 公開日 | 2023-01-18 | | 最終更新日 | 2023-08-02 | | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | | 主引用文献 | Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein.
Front Microbiol, 13, 2022
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7C7P
 | | Crystal structure of the SARS-CoV-2 main protease in complex with Telaprevir | | 分子名称: | (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide, 3C-like proteinase, CHLORIDE ION | | 著者 | Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Yang, S.Y, Lei, J. | | 登録日 | 2020-05-26 | | 公開日 | 2020-07-29 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model.
Science, 371, 2021
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7COM
 | | Crystal structure of the SARS-CoV-2 main protease in complex with Boceprevir (space group P212121) | | 分子名称: | 3C-like proteinase, boceprevir (bound form) | | 著者 | Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Liu, J.M, Zhou, Y.L, Chen, P, Yang, S.Y, Lei, J. | | 登録日 | 2020-08-04 | | 公開日 | 2020-08-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model.
Science, 371, 2021
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7C8B
 | | Crystal structure of the SARS-CoV-2 main protease in complex with Z-VAD(OMe)-FMK | | 分子名称: | 3C-like proteinase, CHLORIDE ION, Z-VAD(OMe)-FMK | | 著者 | Zeng, R, Qiao, J.X, Wang, Y.F, Li, Y.S, Yao, R, Yang, S.Y, Lei, J. | | 登録日 | 2020-05-29 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of the SARS-CoV-2 main protease in complex with Z-VAD(OMe)-FMK
To Be Published
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3DD3
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7FAY
 | | Crystal structure of SARS-CoV-2 main protease in complex with (R)-1a | | 分子名称: | (2~{R})-~{N}-[(1~{R})-2-(~{tert}-butylamino)-2-oxidanylidene-1-pyridin-3-yl-ethyl]-~{N}-(4-~{tert}-butylphenyl)-2-oxidanyl-propanamide, 3C-like proteinase | | 著者 | Zeng, R, Quan, B.X, Liu, X.L, Lei, J. | | 登録日 | 2021-07-08 | | 公開日 | 2021-07-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | An orally available M pro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron.
Nat Microbiol, 7, 2022
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7FAZ
 | | Crystal structure of the SARS-CoV-2 main protease in complex with Y180 | | 分子名称: | (2~{R})-~{N}-dibenzofuran-3-yl-~{N}-[(1~{R})-2-[[(1~{S})-1-(4-fluorophenyl)ethyl]amino]-2-oxidanylidene-1-pyridin-3-yl-ethyl]-2-oxidanyl-propanamide, 3C-like proteinase, SODIUM ION | | 著者 | Zeng, R, Quan, B.X, Liu, X.L, Lei, J. | | 登録日 | 2021-07-08 | | 公開日 | 2021-07-21 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | An orally available M pro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron.
Nat Microbiol, 7, 2022
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7D3I
 | | Crystal structure of SARS-CoV-2 main protease in complex with MI-23 | | 分子名称: | (3~{S},3~{a}~{S},6~{a}~{R})-2-[3-[3,5-bis(fluoranyl)phenyl]propanoyl]-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-3,3~{a},4,5,6,6~{a}-hexahydro-1~{H}-cyclopenta[c]pyrrole-3-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3C-like proteinase | | 著者 | Zeng, R, Li, Y.S, Qiao, J.X, Wang, Y.F, Yang, S.Y, Lei, J. | | 登録日 | 2020-09-19 | | 公開日 | 2020-10-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.004 Å) | | 主引用文献 | SARS-CoV-2 M pro inhibitors with antiviral activity in a transgenic mouse model.
Science, 371, 2021
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7DHL
 | | Crystal structure of FGFR3 in complex with pyrimidine derivative | | 分子名称: | 5-[2-(3,5-dimethoxyphenyl)ethyl]-N-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidin-2-amine, Fibroblast growth factor receptor 3 | | 著者 | Echizen, Y, Tateishi, Y, Amano, Y. | | 登録日 | 2020-11-16 | | 公開日 | 2021-02-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency.
Bioorg.Med.Chem., 33, 2021
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7CX9
 | | Crystal structure of the SARS-CoV-2 main protease in complex with INZ-1 | | 分子名称: | 3-iodanyl-1~{H}-indazole-7-carbaldehyde, 3C-like proteinase, CHLORIDE ION, ... | | 著者 | Zeng, R, Liu, X.L, Qiao, J.X, Nan, J.S, Wang, Y.F, Li, Y.S, Yang, S.Y, Lei, J. | | 登録日 | 2020-09-01 | | 公開日 | 2020-09-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Crystal structure of the SARS-CoV-2 main protease in complex with INZ-1
To Be Published
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3D06
 | | Human p53 core domain with hot spot mutation R249S (I) | | 分子名称: | Cellular tumor antigen p53, ZINC ION | | 著者 | Rozenberg, H, Suad, O, Shimon, L.J.W, Frolow, F, Shakked, Z. | | 登録日 | 2008-05-01 | | 公開日 | 2009-01-20 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
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3D09
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3EZQ
 | | Crystal Structure of the Fas/FADD Death Domain Complex | | 分子名称: | Protein FADD, SODIUM ION, SULFATE ION, ... | | 著者 | Schwarzenbacher, R, Robinson, H, Stec, B, Riedl, S.J. | | 登録日 | 2008-10-23 | | 公開日 | 2008-12-23 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | | 主引用文献 | The Fas-FADD death domain complex structure unravels signalling by receptor clustering
Nature, 457, 2009
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5NNZ
 | | Crystal structure of human ODA16 | | 分子名称: | Dynein assembly factor with WDR repeat domains 1 | | 著者 | Lorentzen, E, Taschner, T, Basquin, J. | | 登録日 | 2017-04-10 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.651 Å) | | 主引用文献 | Purification and crystal structure of human ODA16: Implications for ciliary import of outer dynein arms by the intraflagellar transport machinery.
Protein Sci., 29, 2020
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5O2S
 | | Human KRAS in complex with darpin K27 | | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Debreczeni, J.E, Guillard, S, Kolasinska-Zwierz, P, Breed, J, Zhang, J, Bery, N, Marwood, R, Tart, J, Stocki, P, Mistry, B, Phillips, C, Rabbitts, T, Jackson, R, Minter, R. | | 登録日 | 2017-05-22 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | | 主引用文献 | Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
Nat Commun, 8, 2017
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