5XV7

SRPK1 in complex with Alectinib

Summary for 5XV7

Entry DOI	10.2210/pdb5xv7/pdb
Descriptor	serine-arginine (SR) protein kinase 1, 1,2-ETHANEDIOL, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, ... (4 entities in total)
Functional Keywords	srpk1, alectinib, srpkin-1, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens
Total number of polymer chains	1
Total formula weight	43157.73
Authors	Zeng, C.,Ngo, J.C.K. (deposition date: 2017-06-26, release date: 2018-03-14, Last modification date: 2023-11-22)
Primary citation	Hatcher, J.M.,Wu, G.,Zeng, C.,Zhu, J.,Meng, F.,Patel, S.,Wang, W.,Ficarro, S.B.,Leggett, A.L.,Powell, C.E.,Marto, J.A.,Zhang, K.,Ki Ngo, J.C.,Fu, X.D.,Zhang, T.,Gray, N.S. SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform Cell Chem Biol, 25:460-470.e6, 2018 Cited by PubMed: 29478907 DOI: 10.1016/j.chembiol.2018.01.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.32 Å)

Structure validation