5O2S
Human KRAS in complex with darpin K27
Summary for 5O2S
Entry DOI | 10.2210/pdb5o2s/pdb |
Descriptor | GTPase KRas, darpin K27, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | kras, ras signalling, darpin, nucleotide exchange, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 8 |
Total formula weight | 156828.29 |
Authors | Debreczeni, J.E.,Guillard, S.,Kolasinska-Zwierz, P.,Breed, J.,Zhang, J.,Bery, N.,Marwood, R.,Tart, J.,Stocki, P.,Mistry, B.,Phillips, C.,Rabbitts, T.,Jackson, R.,Minter, R. (deposition date: 2017-05-22, release date: 2017-07-26, Last modification date: 2024-05-08) |
Primary citation | Guillard, S.,Kolasinska-Zwierz, P.,Debreczeni, J.,Breed, J.,Zhang, J.,Bery, N.,Marwood, R.,Tart, J.,Overman, R.,Stocki, P.,Mistry, B.,Phillips, C.,Rabbitts, T.,Jackson, R.,Minter, R. Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange. Nat Commun, 8:16111-16111, 2017 Cited by PubMed: 28706291DOI: 10.1038/ncomms16111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.22 Å) |
Structure validation
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