3D06

Human p53 core domain with hot spot mutation R249S (I)

Summary for 3D06

Entry DOI	10.2210/pdb3d06/pdb
Related	3D05 3D07 3D08 3D09 3D0A
Descriptor	Cellular tumor antigen p53, ZINC ION (3 entities in total)
Functional Keywords	p53, mutant protein, loop-sheet-helix motif, acetylation, activator, alternative splicing, anti-oncogene, apoptosis, cell cycle, covalent protein-rna linkage, cytoplasm, disease mutation, dna-binding, endoplasmic reticulum, glycoprotein, host-virus interaction, li-fraumeni syndrome, metal-binding, methylation, nucleus, phosphoprotein, polymorphism, transcription, transcription regulation, ubl conjugation, zinc
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
Total number of polymer chains	1
Total formula weight	22500.88
Authors	Rozenberg, H.,Suad, O.,Shimon, L.J.W.,Frolow, F.,Shakked, Z. (deposition date: 2008-05-01, release date: 2009-01-20, Last modification date: 2023-11-01)
Primary citation	Suad, O.,Rozenberg, H.,Brosh, R.,Diskin-Posner, Y.,Kessler, N.,Shimon, L.J.W.,Frolow, F.,Liran, A.,Rotter, V.,Shakked, Z. Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations J.Mol.Biol., 385:249-265, 2009 Cited by PubMed: 18996393 DOI: 10.1016/j.jmb.2008.10.063 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation