3D06
Human p53 core domain with hot spot mutation R249S (I)
Summary for 3D06
Entry DOI | 10.2210/pdb3d06/pdb |
Related | 3D05 3D07 3D08 3D09 3D0A |
Descriptor | Cellular tumor antigen p53, ZINC ION (3 entities in total) |
Functional Keywords | p53, mutant protein, loop-sheet-helix motif, acetylation, activator, alternative splicing, anti-oncogene, apoptosis, cell cycle, covalent protein-rna linkage, cytoplasm, disease mutation, dna-binding, endoplasmic reticulum, glycoprotein, host-virus interaction, li-fraumeni syndrome, metal-binding, methylation, nucleus, phosphoprotein, polymorphism, transcription, transcription regulation, ubl conjugation, zinc |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 1 |
Total formula weight | 22500.88 |
Authors | Rozenberg, H.,Suad, O.,Shimon, L.J.W.,Frolow, F.,Shakked, Z. (deposition date: 2008-05-01, release date: 2009-01-20, Last modification date: 2023-11-01) |
Primary citation | Suad, O.,Rozenberg, H.,Brosh, R.,Diskin-Posner, Y.,Kessler, N.,Shimon, L.J.W.,Frolow, F.,Liran, A.,Rotter, V.,Shakked, Z. Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations J.Mol.Biol., 385:249-265, 2009 Cited by PubMed: 18996393DOI: 10.1016/j.jmb.2008.10.063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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