3D0A

Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA

Summary for 3D0A

• Entry DOI: 10.2210/pdb3d0a/pdb
• Related: 3D05 3D06 3D07 3D08 3D09
• Descriptor: DNA (5'-D(*DCP*DGP*DGP*DGP*DCP*DAP*DTP*DGP*DCP*DCP*DCP*DG)-3'), Cellular tumor antigen p53, ZINC ION, ... (4 entities in total)
• Functional Keywords: p53, mutant protein, loop-sheet-helix motif, dna target, acetylation, activator, alternative splicing, anti-oncogene, apoptosis, cell cycle, covalent protein-rna linkage, cytoplasm, disease mutation, dna-binding, endoplasmic reticulum, glycoprotein, host-virus interaction, li-fraumeni syndrome, metal-binding, methylation, nucleus, phosphoprotein, polymorphism, transcription, transcription regulation, ubl conjugation, zinc, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• Total number of polymer chains: 8
• Total formula weight: 104737.21

Authors

Suad, O.,Rozenberg, H.,Shakked, Z. (deposition date: 2008-05-01, release date: 2009-01-20, Last modification date: 2023-11-01)

• Primary citation: Suad, O.,Rozenberg, H.,Brosh, R.,Diskin-Posner, Y.,Kessler, N.,Shimon, L.J.W.,Frolow, F.,Liran, A.,Rotter, V.,Shakked, Z.; Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations; J.Mol.Biol., 385:249-265, 2009; PubMed: 18996393; DOI: 10.1016/j.jmb.2008.10.063

Experimental method

X-RAY DIFFRACTION (1.8 Å)