3D0A
Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (E, F, G, H) | DNA (5'-D(*DCP*DGP*DGP*DGP*DCP*DAP*DTP*DGP*DCP*DCP*DCP*DG)-3') | polymer | 12 | 3664.4 | 4 | |||
| 2 | E, F, G, H (A, B, C, D) | Cellular tumor antigen p53 | polymer | 200 | 22454.5 | 4 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (Human) | Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13 |
| 3 | I, J, K, L (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | M, N, O, P, Q... (E, F, G, H, A...) | water | water | 18.0 | 747 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 94 - 293 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Arg 168 | His 168 | engineered mutation |
| Ser 249 | Arg 249 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 104475.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 104737.2 |
