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7FAZ

Crystal structure of the SARS-CoV-2 main protease in complex with Y180

Summary for 7FAZ
Entry DOI10.2210/pdb7faz/pdb
Descriptor3C-like proteinase, (2~{R})-~{N}-dibenzofuran-3-yl-~{N}-[(1~{R})-2-[[(1~{S})-1-(4-fluorophenyl)ethyl]amino]-2-oxidanylidene-1-pyridin-3-yl-ethyl]-2-oxidanyl-propanamide, SODIUM ION, ... (4 entities in total)
Functional Keywordscoronavirus, protease, inhibitor, complex., viral protein
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains2
Total formula weight68697.17
Authors
Zeng, R.,Quan, B.X.,Liu, X.L.,Lei, J. (deposition date: 2021-07-08, release date: 2021-07-21, Last modification date: 2023-11-29)
Primary citationQuan, B.X.,Shuai, H.,Xia, A.J.,Hou, Y.,Zeng, R.,Liu, X.L.,Lin, G.F.,Qiao, J.X.,Li, W.P.,Wang, F.L.,Wang, K.,Zhou, R.J.,Yuen, T.T.,Chen, M.X.,Yoon, C.,Wu, M.,Zhang, S.Y.,Huang, C.,Wang, Y.F.,Yang, W.,Tian, C.,Li, W.M.,Wei, Y.Q.,Yuen, K.Y.,Chan, J.F.,Lei, J.,Chu, H.,Yang, S.
An orally available M pro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron.
Nat Microbiol, 7:716-725, 2022
Cited by
PubMed: 35477751
DOI: 10.1038/s41564-022-01119-7
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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